GITR/TNFRSF18 Products
GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a transmembrane TNF receptor superfamily member that functions in immune regulation. GITR is expressed on CD4+CD25+ regulatory T cells (Treg) as well as on subsets of thymocytes, lymph node cells, and splenocytes, and it is upregulated on antigen-activated conventional CD4+ and CD8+ T cells. GITR binding by GITR Ligand/TNFSF18 costimulates the proliferation and activation of CD4+ or CD8+ conventional T cells. It also induces the proliferation of Treg but inhibits the ability of Treg to suppress immune responses. This can result in the development of autoimmunity, increased tumor cell killing by effector T cells, and increased inflammation in arthritis, allergic asthma, and inflammatory bowel disease. GITR is also expressed on sympathetic neurons where it enhances NGF-induced neurite outgrowth and branching.
446 results for "GITR/TNFRSF18" in Products
446 results for "GITR/TNFRSF18" in Products
GITR/TNFRSF18 Products
GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a transmembrane TNF receptor superfamily member that functions in immune regulation. GITR is expressed on CD4+CD25+ regulatory T cells (Treg) as well as on subsets of thymocytes, lymph node cells, and splenocytes, and it is upregulated on antigen-activated conventional CD4+ and CD8+ T cells. GITR binding by GITR Ligand/TNFSF18 costimulates the proliferation and activation of CD4+ or CD8+ conventional T cells. It also induces the proliferation of Treg but inhibits the ability of Treg to suppress immune responses. This can result in the development of autoimmunity, increased tumor cell killing by effector T cells, and increased inflammation in arthritis, allergic asthma, and inflammatory bowel disease. GITR is also expressed on sympathetic neurons where it enhances NGF-induced neurite outgrowth and branching.
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #110416 |
| Applications: | WB, Flow, Block, CyTOF-ready |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #110416 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #108619 |
| Applications: | WB, Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #110416 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #110416 |
| Applications: | Flow |
| Reactivity: | Mouse |
| Details: | Rabbit IgG Monoclonal Clone #2375B |
| Applications: | Flow, IHC, CyTOF-ready, ICC |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Source: | NS0 |
| Accession #: | Q8C4K3 |
| Applications: | Bind |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready |
| Reactivity: | Mouse |
| Details: | Rat IgG2b Lambda Monoclonal Clone #DTA-1 |
| Applications: | Flow, IP |
![Flow Cytometry: GITR/TNFRSF18 Antibody (DTA-1) [NBP2-26661]](https://resources.bio-techne.com/images/products/GITR-TNFRSF18-Antibody-DTA-1-Flow-Cytometry-NBP2-26661-img0008.jpg "Flow Cytometry: GITR/TNFRSF18 Antibody (DTA-1) [NBP2-26661]")
| Reactivity: | Human |
| Details: | Rabbit Monoclonal Clone #BLR068G |
| Applications: | IHC, WB, ICC/IF, IP, mIF |
![Immunoprecipitation: GITR/TNFRSF18 Antibody (BLR068G) [NBP3-14683]](https://resources.bio-techne.com/images/products/GITR-TNFRSF18-Antibody-Immunoprecipitation-NBP3-14683-img0001.jpg "Immunoprecipitation: GITR/TNFRSF18 Antibody (BLR068G) [NBP3-14683]")
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #108619 |
| Applications: | Flow |
| Reactivity: | Mouse |
| Details: | Rat IgG1 Monoclonal Clone #108626 |
| Applications: | WB, ELISA(Cap), ELISA(Det) |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #110416 |
| Applications: | Flow |
| Source: | CHO |
| Accession #: | Q9Y5U5.1 |
| Applications: | BA |
