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ERK2 Products
ERK1 and ERK2 (also known as MAPK3 and MAPK1) are 44 and 42 kDa Ser/Thr kinases, respectively. They are part of the Ras-Raf-ERK signal transduction cascade often found downstream of growth factor receptor activation. ERK1 and ERK2 were initially isolated and cloned as kinases activated in response to insulin and NGF. They are expressed in most, if not all, mammalian tissues. Dual threonine and tyrosine phosphorylation activate both ERKs, at Thr202/Tyr204 for human ERK1 and Thr185/Tyr187 for human ERK2.
ERK5, also known as Big Mitogen-activated Protein Kinase 1 (BMK1) and MAPK7, is activated by several mechanisms, including receptor tyrosine kinases, G protein-coupled receptors, and osmotic stress. Like ERK1 and ERK2, ERK5 contains the conserved Thr-Glu-Tyr activation motif in its activation loop. Unlike these ERKs, however, ERK5 contains a unique C-terminal domain that regulates its activation and nuclear translocation.
24 results for "ERK2" in Products
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ERK2 Products
ERK1 and ERK2 (also known as MAPK3 and MAPK1) are 44 and 42 kDa Ser/Thr kinases, respectively. They are part of the Ras-Raf-ERK signal transduction cascade often found downstream of growth factor receptor activation. ERK1 and ERK2 were initially isolated and cloned as kinases activated in response to insulin and NGF. They are expressed in most, if not all, mammalian tissues. Dual threonine and tyrosine phosphorylation activate both ERKs, at Thr202/Tyr204 for human ERK1 and Thr185/Tyr187 for human ERK2.
ERK5, also known as Big Mitogen-activated Protein Kinase 1 (BMK1) and MAPK7, is activated by several mechanisms, including receptor tyrosine kinases, G protein-coupled receptors, and osmotic stress. Like ERK1 and ERK2, ERK5 contains the conserved Thr-Glu-Tyr activation motif in its activation loop. Unlike these ERKs, however, ERK5 contains a unique C-terminal domain that regulates its activation and nuclear translocation.
24 results for "ERK2" in Products
| Clonality : | Monoclonal |
| Host : | Rabbit IgG Clone #269434 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rabbit IgG Clone #269434 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rabbit IgG Clone #269434 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rabbit IgG Clone #269434 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rabbit IgG Clone #269434 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rabbit IgG Clone #269434 |
| Applications : | Flow Cytometry |
| Assay Range : | 469 - 30,000 pg/mL |
| Applications : | ELISA |
| Clonality : | Polyclonal |
| Host : | Rabbit IgG |
| Applications : | CyTOF-ready, Flow Cytometry, Immunohistochemistry, Simple Western, Western Blot |
| Clonality : | Monoclonal |
| Host : | Rabbit IgG Clone #269434 |
| Applications : | CyTOF-ready, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Simple Western, Western Blot |
| Clonality : | Polyclonal |
| Host : | Rabbit IgG |
| Applications : | Simple Western, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #216703 |
| Applications : | Immunohistochemistry, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #631122 |
| Applications : | Western Blot |
| Source : | E. coli |
| Accession # : | NM_002745 |
| Applications : | Bioactivity |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2a Clone #191801 |
| Applications : | Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Knockout Validated, Simple Western, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #798508 |
| Applications : | Western Blot |
| Assay Range : | 78.1 - 5,000 pg/mL |
| Applications : | ELISA |
| Clonality : | Polyclonal |
| Host : | Rabbit IgG |
| Applications : | Immunohistochemistry, Knockout Validated, Western Blot |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Immunohistochemistry, Knockout Validated, Western Blot |
| Clonality : | Monoclonal |
| Host : | Rabbit IgG Clone #269434 |
| Applications : | Flow Cytometry |
Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 37 different kinases and 2 related total proteins
Potent and selective ERK2 inhibitor
| Alternate Names : | VX 11e |
| Chemical Name : | 4-[2-[(2-Chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide |
| Purity : | ≥98% (HPLC) |
High affinity and selective p38 kinase inhibitor
| Alternate Names : | Doramapimod |
| Chemical Name : | N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea |
| Purity : | ≥98% (HPLC) |
Selective ERK inhibitor
| Chemical Name : | 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine |
| Purity : | ≥98% (HPLC) |
ERK dimerization inhibitor
| Chemical Name : | N-[2,3-Dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2-oxo-1H-indol-5-yl]-1-piperidinepropanamide |
| Purity : | ≥98% (HPLC) |
