TCS ERK 11e

Name: TCS ERK 11e
Brand: Tocris Bioscience
SKU: 4465

Tocris Bioscience, part of Bio-Techne | Catalog # 4465

Citations (9)

COA / SDS

Potent and selective ERK2 inhibitor

Key Product Details

Description:	Potent and selective ERK2 inhibitor
Alternative Names:	VX 11e
Chemical Name:	4-[2-[(2-Chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	500.35

View Full Technical Details for TCS ERK 11e

Technical Data
Citations

Biological Activity for TCS ERK 11e

TCS ERK 11e is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (K_i values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC₅₀ = 48 nM). Orally bioavailable.

Compound Libraries for TCS ERK 11e

TCS ERK 11e is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for TCS ERK 11e

M. Wt	500.35
Formula	C₂₄H₂₀Cl₂FN₅O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	896720-20-0
PubChem ID	11634725
InChi Key	WUTVMXLIGHTZJC-OAQYLSRUSA-N
Smiles	O=C(N[C@H](CO)C3=CC(Cl)=CC=C3)C1=CC(C2=NC(NC4=CC=C(F)C=C4Cl)=NC=C2C)=CN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TCS ERK 11e

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	50.03	100
	ethanol	12.51	25

Preparing Stock Solutions for TCS ERK 11e

The following data is based on the product molecular weight 500.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.00 mL	9.99 mL	19.99 mL
5 mM	0.40 mL	2.00 mL	4.00 mL
10 mM	0.20 mL	1.00 mL	2.00 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for TCS ERK 11e

References are publications that support the biological activity of the product.

Aronov Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-related kinase (ERK) using conformational control. J.Med.Chem. 2009 PMID: 19827834