11 results for "DREADD Activators Small Molecules and Peptides" in Products
DREADD Activators: Small Molecules and Peptides
DREADD Mechanism of Action
The first DREADDs to be developed were derived from human muscarinic acetylcholine receptors (mAChRs) and termed hM1-5. These receptors have mutations in their orthosteric binding site, abolishing their affinity for the endogenous ligand ACh, while rendering them responsive to small molecule DREADD ligands, such as Clozapine-N-oxide (CNO, Cat. No. 4936) or Deschloroclozapine (DCZ, Cat. No. 7193).
The effect of ligand binding depends on the G protein-coupling of the ...
Potent hM3Dq and hM4Di DREADD agonist; water soluble version of DREADD agonist 21 (Cat. No. 5548)
| Alternate Names: | Compound 21 (water-soluble) |
| Chemical Name: | 11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride |
| Purity: | ≥98% (HPLC) |
Activator of hM3Dq and hM4Di DREADDs; water soluble version of Clozapine N-oxide (Cat. No. 4936)
| Alternate Names: | CNO (water-soluble) |
| Chemical Name: | 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride |
| Purity: | ≥99% (HPLC) |
Potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant
| Alternate Names: | Compound 21,C21 |
| Chemical Name: | 11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine |
| Purity: | ≥98% (HPLC) |
Activator of hM3Dq and hM4Di DREADDs
| Alternate Names: | CNO |
| Chemical Name: | 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine |
| Purity: | ≥98% (HPLC) |
High affinity and highly potent activator of hM3Dq and hM4Di DREADDs; rapid blood-brain barrier penetrant
| Alternate Names: | DCZ |
| Chemical Name: | 11-(4-Methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine |
| Purity: | ≥98% (HPLC) |
Activator of κ-opioid DREADD (KORD)
| Chemical Name: | (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester |
| Purity: | ≥98% (HPLC) |
High affinity and highly potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant
| Chemical Name: | 8-Chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5H-dibenzo[b,e][1,4]diazepine |
| Purity: | ≥98% (HPLC) |
High affinity and highly potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant
| Chemical Name: | 8-Chloro-11-(4-ethylpiperazin-1-yl)-1-fluoro-5H-dibenzo[b,e][1,4]diazepine |
| Purity: | ≥98% (HPLC) |
Potent hM3Dq and hM4Di DREADD agonist in vitro
| Chemical Name: | 6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepine |
| Purity: | ≥99% (HPLC) |
Selective orthostatic agonist of hFFA2-DREADDs
| Chemical Name: | 4-Methoxy-3-methylbenzoic acid |
| Purity: | ≥98% (HPLC) |
5-HT2A antagonist; also D2 antagonist; atypical antipsychotic
| Chemical Name: | 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine |
| Purity: | ≥98% (HPLC) |
