Olanzapine

Name: Olanzapine
Brand: Tocris Bioscience
SKU: 4349

Tocris Bioscience, part of Bio-Techne | Catalog # 4349

Citations (19)

COA / SDS

5-HT2A antagonist; also D2 antagonist; atypical antipsychotic

Key Product Details

Description:	5-HT_2A antagonist; also D₂ antagonist; atypical antipsychotic
Chemical Name:	2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
Purity:	≥98% (HPLC)
Molecular Weight:	312.43

View Full Technical Details for Olanzapine

Technical Data
Citations

Biological Activity for Olanzapine

Olanzapine is an antagonist of 5-HT_2A and dopamine D₂ receptors (K_i values are 4 and 11 nM respectively). Also displays affinity for a range of other receptors including D₁ and D₄, 5-HT_2C, α₁, H₁ and M_1-4 receptors (K_i values range between 1.9 and 31 nM). Atypical antipsychotic. Displays anticholinergic properties. Also a highly potent activator of hM₄D_i DREADDs (EC₅₀ values are 5 nM in vitro and 7 nM in vivo).

Compound Libraries for Olanzapine

Olanzapine is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Olanzapine

M. Wt	312.43
Formula	C₁₇H₂₀N₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	132539-06-1
PubChem ID	4585
InChi Key	WXPNDRBBWZMPQG-UHFFFAOYSA-N
Smiles	CC4=CC2=C(S4)NC1=CC=CC=C1N=C2N3CCN(C)CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Olanzapine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	31.24	100

Preparing Stock Solutions for Olanzapine

The following data is based on the product molecular weight 312.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.20 mL	16.00 mL	32.01 mL
5 mM	0.64 mL	3.20 mL	6.40 mL
10 mM	0.32 mL	1.60 mL	3.20 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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References for Olanzapine

References are publications that support the biological activity of the product.

Moore The behavioral pharmacology of olanzapine, a novel "atypical" antipsychotic agent. J.Pharmacol.Exp.Ther. 1992 PMID: 1354253
Bymaster Radioreceptor binding profile of the atypical antipsychotic olanz. Neuropsychopharmacology 1996 PMID: 8822531
Tollefson and Taylor Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent. CNS Drug Reviews