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Dihydrofolate Reductase Inhibitors: Small Molecules and Peptides

A member of the reductase family of enzymes, dihydrofolate reductase (DHFR) is ubiquitously expressed in all organisms. It catalyzes tetrahydrofolate regeneration by reduction of dihydrofolate, using NADPH as a cofactor. DHFR plays a key role in cell growth and proliferation.

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4 results for "Dihydrofolate Reductase Inhibitors Small Molecules and Peptides" in Products

4 results for "Dihydrofolate Reductase Inhibitors Small Molecules and Peptides" in Products

Dihydrofolate Reductase Inhibitors: Small Molecules and Peptides

A member of the reductase family of enzymes, dihydrofolate reductase (DHFR) is ubiquitously expressed in all organisms. It catalyzes tetrahydrofolate regeneration by reduction of dihydrofolate, using NADPH as a cofactor. DHFR plays a key role in cell growth and proliferation.

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Photoswitchable inhibitor of human dihydrofolate reductase

Chemical Name: N-[4-[(1E)-2-(2,4-Diamino-6-quinazolinyl)diazenyl]benzoyl]-L-glutamic acid
Purity: ≥95% (HPLC)
Photoswitching activity of Phototrexate
(2)

Thymidylate synthetase inhibitor, also inhibits dihydrofolate reductase, GARFT and AICART

Chemical Name: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid
Purity: ≥98% (HPLC)
Thymidylate synthetase inhibitor, also inhibits dihydrofolate reductase, GARFT and AICART

Cytotoxic agent

Chemical Name: N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Purity: ≥98% (HPLC)
Cytotoxic agent

Potent inhibitor of multidrug and toxin extrusion (MATE) transporters; also DHFR and STAT3 inhibitor

Chemical Name: 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine
Purity: ≥98% (HPLC)
Potent inhibitor of multidrug and toxin extrusion (MATE) transporters; also  DHFR and STAT3 inhibitor
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