Clusterin: Antibodies
Clusterin, also known as Apolipoprotein J, Sulfated Glycoprotein 2 (SGP-2), TRPM-2, and SP-40,40, is a secreted multifunctional protein that binds a wide range of molecules and may function as a chaperone of misfolded extracellular proteins. It also participates in the control of cell proliferation, apoptosis, and carcinogenesis. Clusterin is predominantly expressed in adult testis, ovary, adrenal gland, liver, heart, and brain and in many epithelial tissues during embryonic development. It is secreted as a disulfide-linked heterodimer of alpha and beta chains and circulates as a component of high density lipoprotein (HDL) particles. Clusterin exerts tissue protective functions in atherosclerosis and Alzheimer’s disease by binding and neutralizing non-oxidatively modified LDL reduces cytotoxicity and beta-amyloid fibrils, respectively. Increased circulating levels of Clusterin enhance tumor aggressiveness by inhibiting apoptosis and by promoting epithelial to mesenchymal transition.
9 results for "Clusterin Primary Antibodies" in Products
Search
Application
Conjugates
Clonality
Host Species
Isotype
Clone
Low Endotoxin
Sample Size
Citations
Reviews
Clusterin: Antibodies
Clusterin, also known as Apolipoprotein J, Sulfated Glycoprotein 2 (SGP-2), TRPM-2, and SP-40,40, is a secreted multifunctional protein that binds a wide range of molecules and may function as a chaperone of misfolded extracellular proteins. It also participates in the control of cell proliferation, apoptosis, and carcinogenesis. Clusterin is predominantly expressed in adult testis, ovary, adrenal gland, liver, heart, and brain and in many epithelial tissues during embryonic development. It is secreted as a disulfide-linked heterodimer of alpha and beta chains and circulates as a component of high density lipoprotein (HDL) particles. Clusterin exerts tissue protective functions in atherosclerosis and Alzheimer’s disease by binding and neutralizing non-oxidatively modified LDL reduces cytotoxicity and beta-amyloid fibrils, respectively. Increased circulating levels of Clusterin enhance tumor aggressiveness by inhibiting apoptosis and by promoting epithelial to mesenchymal transition.
9 results for "Clusterin Primary Antibodies" in Products
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Immunohistochemistry, Immunoprecipitation, Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #350270 |
Applications : | ELISA Capture, Immunohistochemistry |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | ELISA Capture, Immunohistochemistry, Immunoprecipitation, Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #350207 |
Applications : | ELISA Detection |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | ELISA Detection, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #350227 |
Applications : | Immunohistochemistry, Immunoprecipitation, Western Blot |
Clonality : | Polyclonal |
Host : | Sheep IgG |
Applications : | Immunohistochemistry, Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #350207 |
Applications : | ELISA |