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CD161: Antibodies

CD161, also known as KLRB1, NK1.1, and NKR-P1A is a 40 kDa type II transmembrane glycoprotein that contains one C-type lectin domain in its extracellular region. CD161 is expressed as a disulfide-linked dimer on the surface of Th17 cells and NK cells as well as on subsets of CD1-restricted T cells, intestinal NT cells, peripheral memory T cells, monocytes, and dendritic cells. It binds to OCIL/CLEC2d, leading to an inhibition of NK cell-mediated cytotoxicity and IFN-gamma secretion. Alternatively, CD161 can enhance TCR activation to CD1d ligation. CD161+ cell populations are depleted in ulcerative colitis, Grave's disease, and AIDS, although CD161+ T cells are activated during asthmatic attacks. Additional related proteins are expressed in mouse but not human: the inhibitory NKR-P1B and D, and the stimulatory NKR-P1A, C, and F.

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207 results for "CD161 Primary Antibodies" in Products

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CD161: Antibodies

CD161, also known as KLRB1, NK1.1, and NKR-P1A is a 40 kDa type II transmembrane glycoprotein that contains one C-type lectin domain in its extracellular region. CD161 is expressed as a disulfide-linked dimer on the surface of Th17 cells and NK cells as well as on subsets of CD1-restricted T cells, intestinal NT cells, peripheral memory T cells, monocytes, and dendritic cells. It binds to OCIL/CLEC2d, leading to an inhibition of NK cell-mediated cytotoxicity and IFN-gamma secretion. Alternatively, CD161 can enhance TCR activation to CD1d ligation. CD161+ cell populations are depleted in ulcerative colitis, Grave's disease, and AIDS, although CD161+ T cells are activated during asthmatic attacks. Additional related proteins are expressed in mouse but not human: the inhibitory NKR-P1B and D, and the stimulatory NKR-P1A, C, and F.

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207 results for "CD161 Primary Antibodies" in Products

Flow, CyTOF-ready
Catalog #: FAB7448T
Flow
Flow
Flow
Flow
Catalog #: FAB7448V
Flow
Catalog #: FAB7448U
Flow
Flow, CyTOF-ready
IHC, ICC/IF, Flow, IP, WB (-)
Flow
Catalog #: FAB7448R
Flow
Catalog #: FAB7448S
Flow
Catalog #: FAB9766S
Flow
Catalog #: FAB9766N
Flow
Catalog #: FAB9766V
Flow
Catalog #: FAB9766T
Flow
Catalog #: FAB9766U
Flow
Catalog #: FAB9766G
Flow
WB, Flow

Clone HP-3G10 was used by HLDA to establish CD designation.

ELISA

Recombinant Monoclonal Antibody

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