5 results for "ALK/CD246" in Products
ALK/CD246 Products
Anaplastic Lymphoma Kinase (ALK), also known as CD246, is a 220 kDa transmembrane glycoprotein that is primarily expressed in the developing nervous system. ALK contains one LDL Receptor (LDLR) class A domain, two meprin/A5-protein/PTPmu (MAM) domains, and a cytoplasmic kinase domain. Chromosomal translocation involving ALK and the nucleolar NPM protein result in a cytoplasmic fusion protein that exists as a dimer. The kinase domain in NPM-ALK is constitutively active and participates in cellular transformation. ALK translocations are found in a variety of tumors. Within the extracellular domain, human and mouse ALK share 88% amino acid sequence identity.
Potent IR and IGF1R inhibitor; also inhibits anaplastic lymphoma kinase (ALK)
Potent anaplastic lymphoma kinase (ALK) inhibitor; also potent ACK inhibitor
Highly potent ALK inhibitor; also potently inhibits IR, IGF1R, STK22D and FLT3
Potent and selective ALK2 inhibitor
Potent and selective ALK2 inhibitor