Ceritinib
Tocris Bioscience, part of Bio-Techne | Catalog # 6905
Highly potent ALK inhibitor; also potently inhibits IR, IGF1R, STK22D and FLT3
Key Product Details
Description
Highly potent ALK inhibitor; also potently inhibits IR, IGF1R, STK22D and FLT3
Alternative Names
LDK378
Product Description
Ceritinib is a highly potent anaplastic lymphoma kinase (ALK) inhibitor (IC50 = 0.2 nM). Also displays potent inhibition of insulin receptor (IR), insulin-like growth factor receptor 1 (IGF1R), serine/threonine-protein kinase STK22D and FLT3 (IC50 values are 7, 8, 23 and 60 nM, respectively). Inhibits tumor growth in Karpas299 and H2228 rat xenograft models.Product Specifications
Molecular Weight
558.14
Formula
C28H36ClN5O3S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine
CAS Number
1032900-25-6
PubChem ID
57379345
InChI Key
VERWOWGGCGHDQE-UHFFFAOYSA-N
SMILES
CC(C)OC1=C(NC2=NC=C(Cl)C(NC3=C(C=CC=C3)[S](=O)(=O)C(C)C)=N2)C=C(C)C(=C1)C1CCNCC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.79 | 5 with gentle warming | |
| Ethanol | 2.79 | 5 with gentle warming |
Preparing Stock Solutions
for Ceritinib
The following data is based on the product molecular weight 558.14
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 35.83 mL | 179.17 mL | 358.33 mL |
| 0.25 mM | 7.17 mL | 35.83 mL | 71.67 mL |
| 0.5 mM | 3.58 mL | 17.92 mL | 35.83 mL |
| 2.5 mM | 0.72 mL | 3.58 mL | 7.17 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Marsilje Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials. J.Med.Chem. 2013 PMID: 23742252
Product Specific Notices for Ceritinib
For research use only
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