M4K2163 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 7754

Potent and selective ALK2 inhibitor
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Key Product Details

Description

Potent and selective ALK2 inhibitor

View all ALK Inhibitors »

Product Description

M4K2163 is a potent and selective activin receptor-like kinase 2 (ALK2) inhibitor (IC50 values are 19 nM in vivo and 98 nM in vitro). Orally bioavailable and brain penetrant.

Product Specifications

Molecular Weight

480.41

Formula

C24H26FN3O2.2HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

1-[4-[5-(4-Fluoro-3,5-dimethoxyphenyl)-4-methyl-3-pyridinyl]phenyl]piperazine dihydrochloride

CAS Number

2863635-04-3

InChI Key

HMNLQIQCOZETBK-UHFFFAOYSA-N

SMILES

FC1=C(OC)C=C(C2=CN=CC(C3=CC=C(N4CCNCC4)C=C3)=C2C)C=C1OC.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 48.04 100
DMSO 48.04 100

Preparing Stock Solutions for M4K2163 dihydrochloride

The following data is based on the product molecular weight 480.41

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.08 mL 10.41 mL 20.82 mL
5 mM 0.42 mL 2.08 mL 4.16 mL
10 mM 0.21 mL 1.04 mL 2.08 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for M4K2163 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for M4K2163 dihydrochloride

For research use only

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