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Abl Kinase Inhibitors Products

c-Abl (Abelson murine leukemia viral homolog 1) is a cytosolic member of the ABL subfamily, protein tyrosine kinase family of enzymes. It is ubiquitously expressed, and participates in multiple processes such as cell migration, actin reorganization, DNA damage response and apoptosis. Human c-Abl (I-B) is 1149 amino acids (aa) in length. It is myristoylated on Gly2 and contains one SH3 domain (aa 80-140), an SH2 domain (aa 146-236), a protein kinase region (aa 261-512), three NLS's (aa 620-634; 726-739; 778-791), one DNA-binding region (aa 888-988), an NES motif (aa 1109-1119) and an actin F-binding domain (aa 1120-1149). There is one alternate splice form (I-A) that contains a 26 aa substitution for the N-terminal 45 amino acids. In chronic myelogenous leukemia, c-Abl is fused to the Bcr gene product, resulting in the production of a constitutively active tyrosine kinase.

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Abl Kinase Inhibitors Products

c-Abl (Abelson murine leukemia viral homolog 1) is a cytosolic member of the ABL subfamily, protein tyrosine kinase family of enzymes. It is ubiquitously expressed, and participates in multiple processes such as cell migration, actin reorganization, DNA damage response and apoptosis. Human c-Abl (I-B) is 1149 amino acids (aa) in length. It is myristoylated on Gly2 and contains one SH3 domain (aa 80-140), an SH2 domain (aa 146-236), a protein kinase region (aa 261-512), three NLS's (aa 620-634; 726-739; 778-791), one DNA-binding region (aa 888-988), an NES motif (aa 1109-1119) and an actin F-binding domain (aa 1120-1149). There is one alternate splice form (I-A) that contains a 26 aa substitution for the N-terminal 45 amino acids. In chronic myelogenous leukemia, c-Abl is fused to the Bcr gene product, resulting in the production of a constitutively active tyrosine kinase.

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9 results for "Abl Kinase Inhibitors" in Products

Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit

Src family kinase inhibitor; also inhibits c-Abl

Potent inhibitor of Abl T315l mutant and wild-type Abl kinases

Potent EGFR-kinase inhibitor

Highly potent pan-Src/Bcr-Abl inhibitor

Potent multi-kinase and pan-Bcr-Abl inhibitor

Dual Src-Abl inhibitor; antiproliferative

Potent PDGFRα and PDGFRβ inhibitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases

Selective allosteric inhibitor of Bcr-Abl; analog of GNF 2 (Cat. No. 4399)

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