Abl Kinase Inhibitors Products
c-Abl (Abelson murine leukemia viral homolog 1) is a cytosolic member of the ABL subfamily, protein tyrosine kinase family of enzymes. It is ubiquitously expressed, and participates in multiple processes such as cell migration, actin reorganization, DNA damage response and apoptosis. Human c-Abl (I-B) is 1149 amino acids (aa) in length. It is myristoylated on Gly2 and contains one SH3 domain (aa 80-140), an SH2 domain (aa 146-236), a protein kinase region (aa 261-512), three NLS's (aa 620-634; 726-739; 778-791), one DNA-binding region (aa 888-988), an NES motif (aa 1109-1119) and an actin F-binding domain (aa 1120-1149). There is one alternate splice form (I-A) that contains a 26 aa substitution for the N-terminal 45 amino acids. In chronic myelogenous leukemia, c-Abl is fused to the Bcr gene product, resulting in the production of a constitutively active tyrosine kinase.
8 results for "Abl Kinase Inhibitors" in Products
8 results for "Abl Kinase Inhibitors" in Products
Abl Kinase Inhibitors Products
c-Abl (Abelson murine leukemia viral homolog 1) is a cytosolic member of the ABL subfamily, protein tyrosine kinase family of enzymes. It is ubiquitously expressed, and participates in multiple processes such as cell migration, actin reorganization, DNA damage response and apoptosis. Human c-Abl (I-B) is 1149 amino acids (aa) in length. It is myristoylated on Gly2 and contains one SH3 domain (aa 80-140), an SH2 domain (aa 146-236), a protein kinase region (aa 261-512), three NLS's (aa 620-634; 726-739; 778-791), one DNA-binding region (aa 888-988), an NES motif (aa 1109-1119) and an actin F-binding domain (aa 1120-1149). There is one alternate splice form (I-A) that contains a 26 aa substitution for the N-terminal 45 amino acids. In chronic myelogenous leukemia, c-Abl is fused to the Bcr gene product, resulting in the production of a constitutively active tyrosine kinase.
Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit
| Alternate Names: | Gleevec,CGP 57148B |
| Chemical Name: | 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonate |
| Purity: | ≥98% (HPLC) |
Potent inhibitor of Abl T315l mutant and wild-type Abl kinases
| Chemical Name: | 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethyl-3-pyridinecarboxamide |
| Purity: | ≥98% (HPLC) |
Src family kinase inhibitor; also inhibits c-Abl
| Alternate Names: | 1-NA-PP 1 |
| Chemical Name: | 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Purity: | ≥99% (HPLC) |
Highly potent pan-Src/Bcr-Abl inhibitor
| Alternate Names: | BMS-354825 |
| Chemical Name: | N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide |
| Purity: | ≥98% (HPLC) |
Potent multi-kinase and pan-Bcr-Abl inhibitor
| Alternate Names: | Ponatinib |
| Chemical Name: | 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide |
| Purity: | ≥98% (HPLC) |
Dual Src-Abl inhibitor; antiproliferative
| Alternate Names: | SKI-606 |
| Chemical Name: | 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile |
| Purity: | ≥99% |
Potent PDGFRα and PDGFRβ inhibitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases
| Chemical Name: | N-(3-Fluorophenyl)-1,4-dihydro-6,7-dimethoxyindeno[1,2-c]pyrazol-3-amine |
| Purity: | ≥98% (HPLC) |
Selective allosteric inhibitor of Bcr-Abl; analog of GNF 2 (Cat. No. 4399)
| Chemical Name: | N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide |
| Purity: | ≥98% (HPLC) |
