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A20/TNFAIP3 Products

A20, also known as TNF-alpha-induced Protein 3 (TNFAIP3) is a 790 amino acid (aa) cytoplasmic protein with a predicted molecular weight of 90 kDa. It was originally described as a protein upregulated by TNF-alpha stimulation. Human A20/TNFAIP3 exhibits 88% aa sequence identity to its mouse ortholog. Structurally, it contains seven zinc finger domains, one of which has Ubiquitin ligase (E3) activity. The N-terminus contains a deubiquitinating enzyme (DUB) domain. As such, A20/TNFAIP3 can be classified as a dual function Ubiquitin editing enzyme. It is known for its ability to modulate inflammatory immune responses by acting as a negative feedback regulator of NF?B signaling. Some putative mechanisms include its ability to modulate upstream components of the NF?B pathway such as RIP1, TRAF2, and TRAF6. Deficiencies in A20/TNFAIP3 have been associated with lymphoid malignancies, and the development of inflammatory and autoimmune disorders.

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120 results for "A20/TNFAIP3" in Products

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A20/TNFAIP3 Products

A20, also known as TNF-alpha-induced Protein 3 (TNFAIP3) is a 790 amino acid (aa) cytoplasmic protein with a predicted molecular weight of 90 kDa. It was originally described as a protein upregulated by TNF-alpha stimulation. Human A20/TNFAIP3 exhibits 88% aa sequence identity to its mouse ortholog. Structurally, it contains seven zinc finger domains, one of which has Ubiquitin ligase (E3) activity. The N-terminus contains a deubiquitinating enzyme (DUB) domain. As such, A20/TNFAIP3 can be classified as a dual function Ubiquitin editing enzyme. It is known for its ability to modulate inflammatory immune responses by acting as a negative feedback regulator of NF?B signaling. Some putative mechanisms include its ability to modulate upstream components of the NF?B pathway such as RIP1, TRAF2, and TRAF6. Deficiencies in A20/TNFAIP3 have been associated with lymphoid malignancies, and the development of inflammatory and autoimmune disorders.

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120 results for "A20/TNFAIP3" in Products

CyTOF-ready, Flow, ICC/IF, IHC, IP, Simple Western, WB
IHC, ICC
Flow, ICC/IF, IHC, WB

Recombinant Monoclonal Antibody.

WB, Simple Western, IHC
ELISA, ICC/IF, IHC, WB
ELISA, ICC/IF, IHC, WB
IHC, WB

Recombinant Monoclonal Antibody

AP, ELISA, MA, WB
AP, ELISA, MA, WB
ICC/IF
Catalog #: NBP1-89337PEP
AC
Catalog #: NBP2-68857PEP
AC
Catalog #: NBP1-77351PEP
AC
Catalog #: NBP1-77024PEP
AC

Contains 4 membranes-each spotted in duplicate with 49 different antibodies to ubiquitin target proteins

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