CGP 74514 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 5472

Potent CDK1 inhibitor
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Key Product Details

Description

Potent CDK1 inhibitor

View all CDK1 Subfamily Inhibitors »

Product Description

CGP 74514 dihydrochloride is a potent cdk1 inhibitor (IC50 = 25 nM). Reduces Akt phosphorylation and increases mitochondrial damage in leukemia cells in vitro in combination with LY 294002.

Product Specifications

Molecular Weight

458.82

Formula

C19H24ClN7.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

rel-N2-[(1R,2S)-2-Aminocyclohexyl]-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine dihydrochloride

PubChem ID

121513864

InChI Key

YFAKNNUHXLCNLG-FZMMWMHASA-N

SMILES

CCN2C1=NC(N[C@@H]4CCCC[C@@H]4N)=NC(NC3=CC(Cl)=CC=C3)=C1N=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 22.94 50
DMSO 45.88 100

Preparing Stock Solutions for CGP 74514 dihydrochloride

The following data is based on the product molecular weight 458.82

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.18 mL 10.90 mL 21.80 mL
5 mM 0.44 mL 2.18 mL 4.36 mL
10 mM 0.22 mL 1.09 mL 2.18 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for CGP 74514 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CGP 74514 dihydrochloride

For research use only

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