SN 38

Product Description

SN 38 is an active metabolite of CPT-11 (Cat. No. 2688) that inhibits DNA topoisomerase I (IC₅₀ values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC₅₀ values are 0.077 and 1.3 μM respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC₅₀ values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).

Solubility

Preparing Stock Solutions for SN 38

The following data is based on the product molecular weight 392.40

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.10 mL	25.48 mL	50.97 mL
2.5 mM	1.02 mL	5.10 mL	10.19 mL
5 mM	0.51 mL	2.55 mL	5.10 mL
25 mM	0.10 mL	0.51 mL	1.02 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Gao Synthesis and antitumor activity of the hexacyclic camptothecin derivatives. Bioorg.Med.Chem.Lett. 2005 PMID: 15913996
• Koizumi Novel SN-38-incorporating ploymeric micelles, NK012, eradicate vascular endothelial growth factor-Secr.g bulky tumors. Cancer Res. 2006 PMID: 17047068
• Kawato Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res. 1991 PMID: 1651156