CPT 11

Tocris Bioscience, part of Bio-Techne | Catalog # 2688

DNA topoisomerase I inhibitor; antitumor
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Key Product Details

Description

DNA topoisomerase I inhibitor; antitumor

Alternative Names

Irinotecan,Camptothecin 11

View all DNA Topoisomerase Inhibitors »

Product Description

CPT 11 is an inhibitor of DNA topoisomerase I that displays antitumor activity against a range of tumor types. Active metabolite available (SN 38, Cat. No. 2684).

Product Specifications

Molecular Weight

623.14

Formula

C33H38N4O6.HCl

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(4S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyranoindolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylic acid ester hydrochloride

CAS Number

100286-90-6

PubChem ID

74990

InChI Key

GURKHSYORGJETM-WAQYZQTGSA-N

SMILES

CCC2=C4C(C(N3C4)=CC([C@](CC)(O)C(OC5)=O)=C5C3=O)=NC1=CC=C(OC(N6CCC(N7CCCCC7)CC6)=O)C=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 3.12 5 with gentle warming
DMSO 62.31 100

Preparing Stock Solutions for CPT 11

The following data is based on the product molecular weight 623.14

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.60 mL 8.02 mL 16.05 mL
5 mM 0.32 mL 1.60 mL 3.21 mL
10 mM 0.16 mL 0.80 mL 1.60 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

Calculators

Molarity Calculator

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Reconstitution Calculator

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Product Documents for CPT 11

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CPT 11

For research use only

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