SJ 11646
Tocris Bioscience, part of Bio-Techne | Catalog # 7721
Potent and selective LCK Degrader (PROTAC®)
Key Product Details
Description
Potent and selective LCK Degrader (PROTAC®)
Product Description
SJ 11646 is a potent LCK (lymphocyte-specific protein tyrosine kinase) Degrader (PROTAC®; DC50 = 0.00838 pM). It comprises Dasatinib (Cat. No. 6793), as the LCK ligand, and a phenyl glutarimide-based cereblon binder. It shows cytotoxicity in LCK-activated T cell acute lymphoblastic leukemia (T-ALL) cell lines and primary leukemia samples in vitro. In vivo, SJ11646 shows anti-leukemic efficacy in patient-derived xenograft models of T-ALL.LCK antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF3704 and MAB37041.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Licensing Information
Sold under license from St. Jude Children's Research Hospital.Product Specifications
Molecular Weight
746.28
Formula
C36H40ClN9O5S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(2-Chloro-6-methylphenyl)-2-((6-(4-(3-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetamido)propyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
CAS Number
2933135-82-9
InChI Key
AJNQGWOQPRWRML-UHFFFAOYSA-N
SMILES
CC1=NC(NC2=NC=C(C(NC3=C(C=CC=C3Cl)C)=O)S2)=CC(N4CCN(CC4)CCCNC(COC5=CC=C(C=C5)C6CCC(NC6=O)=O)=O)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.93 | 20 |
Preparing Stock Solutions
for SJ 11646
The following data is based on the product molecular weight 746.28
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 6.70 mL | 33.50 mL | 67.00 mL |
| 1 mM | 1.34 mL | 6.70 mL | 13.40 mL |
| 2 mM | 0.67 mL | 3.35 mL | 6.70 mL |
| 10 mM | 0.13 mL | 0.67 mL | 1.34 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hu Preclinical evaluation of proteolytic targeting of LCK as a therapeutic approach in T cell acute lymphoblastic leukemia. Sci.Transl.Med. 2022 PMID: 36001679
Product Specific Notices for SJ 11646
For research use only
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