SJ 11646

Name: SJ 11646
Brand: Tocris Bioscience
SKU: 7721

Tocris Bioscience, part of Bio-Techne | Catalog # 7721

COA / SDS

Potent and selective LCK Degrader (PROTAC®)

Key Product Details

Description:	Potent and selective LCK Degrader (PROTAC^®)
Chemical Name:	N-(2-Chloro-6-methylphenyl)-2-((6-(4-(3-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetamido)propyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	746.28

View Full Technical Details for SJ 11646

Technical Data
Citations

Biological Activity for SJ 11646

SJ 11646 is a potent LCK (lymphocyte-specific protein tyrosine kinase) Degrader (PROTAC^®; DC₅₀ = 0.00838 pM). It comprises Dasatinib (Cat. No. 6793), as the LCK ligand, and a phenyl glutarimide-based cereblon binder. It shows cytotoxicity in LCK-activated T cell acute lymphoblastic leukemia (T-ALL) cell lines and primary leukemia samples in vitro. In vivo, SJ11646 shows anti-leukemic efficacy in patient-derived xenograft models of T-ALL.

LCK antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF3704 and MAB37041.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from St. Jude Children's Research Hospital.

Technical Data for SJ 11646

M. Wt	746.28
Formula	C₃₆H₄₀ClN₉O₅S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2933135-82-9
InChi Key	AJNQGWOQPRWRML-UHFFFAOYSA-N
Smiles	CC1=NC(NC2=NC=C(C(NC3=C(C=CC=C3Cl)C)=O)S2)=CC(N4CCN(CC4)CCCNC(COC5=CC=C(C=C5)C6CCC(NC6=O)=O)=O)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SJ 11646

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	14.93	20

Preparing Stock Solutions for SJ 11646

The following data is based on the product molecular weight 746.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	6.70 mL	33.50 mL	67.00 mL
1 mM	1.34 mL	6.70 mL	13.40 mL
2 mM	0.67 mL	3.35 mL	6.70 mL
10 mM	0.13 mL	0.67 mL	1.34 mL

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References for SJ 11646

References are publications that support the biological activity of the product.

Hu Preclinical evaluation of proteolytic targeting of LCK as a therapeutic approach in T cell acute lymphoblastic leukemia. Sci.Transl.Med. 2022 PMID: 36001679