SAG New
Tocris Bioscience, part of Bio-Techne | Catalog # TB4366-RMU
SAG synthesized to Ancillary Material Grade
Key Product Details
Description
SAG synthesized to Ancillary Material Grade
Product Description
SAG (TB4366-RMU) is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); antagonizes Cyclopamine (Cat. No. 1623) action at the Smo receptor. SAG potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM) and induces pathway activation independently of Ptch proteins. SAG is a putative inhibitor of a cellular component required for Hedgehog signaling and also enhances neuronal differentiation of iPSCs into dopaminergic neurons. TB4366-RMU is an Ancillary Material Grade version of SAG (Cat. No. 4366). Suitable for use as an ancillary reagent in the further manufacturing of cell therapies.Find out more about our Ancillary Material Grade product range.
Product Specifications
Molecular Weight
490.06
Formula
C28H28ClN3OS
Storage
Store at -20°C (± 5°C)
Purity
≥98%
Chemical Name
3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide
CAS Number
912545-86-9
InChI Key
VFSUUTYAEQOIMW-UHFFFAOYSA-N
SMILES
ClC2=C(C(N([C@H]4CC[C@H](NC)CC4)CC3=CC=CC(C5=CC=NC=C5)=C3)=O)SC1=CC=CC=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Product Specific Notices for SAG
For research use only
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