Key Product Details
Description: | Potent Smoothened receptor agonist; activates the Hedgehog signaling pathway |
Chemical Name: | 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 490.06 |
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Citations for SAG (5)
Citations are publications that use Bio-Techne products. Selected citations for SAG include:
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Haidar et al.
(2019)
Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies.
Autophagy.
15:1051
PMID: 30669930 -
Atzmon et al.
(2018)
Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy.
Front Mol Neurosci.
11:336
PMID: 30279648 -
Rajamani et al.
(2018)
Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses.
Cell Stem Cell.
22:698
PMID: 29681516 -
Xia et al.
(2016)
Transcriptional comparison of human induced and primary midbrain DArgic neurons.
Sci.Rep..
6:20270
PMID: 26842779 -
Cortes et al.
(2015)
Accumulation of the Vitamin D Precursor Cholecalciferol Antagonizes Hedgehog Signaling to Impair Hemogenic Endothelium Formation.
Nat Chem Biol.
5:471
PMID: 26365513
There are no citations that match your criteria.
Customer Reviews for SAG (2)
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Species: HumanAssay Type: In VitroCell Line/Tissue: HepG2, and Huh,SAG consistently produced positive results in our experiments; it promoted the formation of cilia and reduced the proliferation of cancer cells.We use 5-20 nm concentration for 24-48 hours.
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Species: MouseAssay Type: In VitroCell Line/Tissue: iPSCiPSC-derived hypothalamic neuron differentiation activation by Smoothened agonist SAG 1 μM and purmorphamine 1 μM.From Day 2 to day 9 to direct the cells toward ventral diencephalon with regular media change every 2 days.
There are no reviews that match your criteria.