Cyclopamine

Tocris Bioscience, part of Bio-Techne | Catalog # 1623

Inhibitor of Hedgehog (Hh) signaling
Catalog #
Availability
Size / Price
Qty
1623/1
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Description

Inhibitor of Hedgehog (Hh) signaling

View all Hedgehog Signaling Inhibitors »

Product Description

Cyclopamine is an inhibitor of hedgehog (Hh) signaling, likely via direct inhibition of Smoothened, the accessory protein to the putative Hh receptor Patched. Anticancer and teratogenic in vivo. Depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment. Can also be used to induce differentiation of human embryonic stem cells (hESCs) into hormone-expressing endocrine cells.

Product Specifications

Molecular Weight

411.63

Formula

C27H41NO2

Storage

Desiccate at -20°C

Purity

≥97% (HPLC)

Chemical Name

(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol

CAS Number

4449-51-8

PubChem ID

442972

InChI Key

QASFUMOKHFSJGL-LAFRSMQTSA-N

SMILES

O[C@H](C2)CC[C@@]1(C)C2=CC[C@]([C@@]([H])3CC[C@@]54O[C@@](C[C@H](C)CN6)([H])[C@]6([H])[C@H]5C)([H])[C@@]([H])1CC3=[C@@]4C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Ethanol 2.06 5

Preparing Stock Solutions for Cyclopamine

The following data is based on the product molecular weight 411.63

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 48.59 mL 242.94 mL 485.87 mL
0.25 mM 9.72 mL 48.59 mL 97.17 mL
0.5 mM 4.86 mL 24.29 mL 48.59 mL
2.5 mM 0.97 mL 4.86 mL 9.72 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

x
=
x

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for Cyclopamine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Cyclopamine

For research use only

Privacy Policy
Cookie Policy
Site Map
© Copyright 2026 Bio-Techne. All Rights Reserved. All trademarks and registered trademarks are the property of Bio-Techne and its brands unless otherwise specified.