(S)-(+)-Dimethindene maleate
Tocris Bioscience, part of Bio-Techne | Catalog # 1425
Selective M2 antagonist
Product Description
(S)-(+)-Dimethindene maleate is an enantiomer that is a subtype-selective M2 muscarinic receptor antagonist (pKi values are 7.08, 7.78, 6.70 and 7.00 for M1, M2, M3 and M4 receptors respectively). Also H1 histamine receptor antagonist (pKi = 7.48). Allows formation of extended pluripotent stem (EPS) cells (see our protocol below) in combination with CHIR 99021 (Cat.No. 4423), minocycline hydrochloride (Cat.No. 3268) and human leukemia inhibitory factor.For more information about how Dimethindene maleate may be used, see our protocol: Generation and Propagation of EPS cells (LCDM Cocktail).
Product Specifications
Molecular Weight
408.50
Formula
C20H24N2.C4H4O4
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
N,N-Dimethyl-3-[(1S)-1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine maleate
CAS Number
136152-65-3
PubChem ID
56972160
InChI Key
SWECWXGUJQLXJF-HFNHQGOYSA-N
SMILES
C[C@H](C3=NC=CC=C3)C2=C(CCN(C)C)CC1=CC=CC=C12.OC(=O)\C=C/C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 29.24 | 100 with gentle warming |
Preparing Stock Solutions
for (S)-(+)-Dimethindene maleate
The following data is based on the product molecular weight 408.50
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.45 mL | 12.24 mL | 24.48 mL |
| 5 mM | 0.49 mL | 2.45 mL | 4.90 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.45 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Pfaff The (S)-(+)-enantiomer of dimethindene: a novel M2-selective muscarinic receptor antagonist. Eur.J.Pharmacol. 1995 PMID: 8608784
- Yang Derivation of pluripotent stem cells with in vivo embryonic and extraembryonic potency. Cell. 2017 PMID: 28388409
- Lambrecht Neuronal soma-dendritic and prejunctional M1-M4 receptors in gastrointestinal and genitourinary smooth muscle. Life Sci. 1999 PMID: 10069503
Product Specific Notices for (S)-(+)-Dimethindene maleate
For research use only
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