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Minocycline hydrochloride

Tocris Bioscience a Bio-Techne Brand

Minocycline hydrochloride | CAS No. 13614-98-7 | Antibiotic. Displays neuroprotective effects
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Key Product Details

Description: Antibiotic. Displays neuroprotective effects
Chemical Name: [4S-(4α,4aα,5aα,12aα)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a,tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
Purity: ≥98% (HPLC)
Molecular Weight: 493.94

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  • Blocker of microglia reactivity
    Name: Luiz Alexandre Magno
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: Brain
    I have used the antibiotic minocycline to impair activation of microglia in the brain of mice. This drug has anti-inflammatory properties that block microglial reactivity, which can be easily confirmed by expression of the CD68 protein. The drug was diluted in PBS and injected i.p. (75 mg/kg) in mice, twice a day, for 7 days. The image shows that microglial cells (stained for Iba1) do not express CD68 (in red) after treatment with minocycline.
    Minocycline hydrochloride Serum 3268

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Product Documents for Minocycline hydrochloride

Certificate of Analysis

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⚠ WARNING: This product can expose you to chemicals including Minocycline hydrochloride (internal use), which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to