(S)-(+)-Dimethindene maleate

Name: ( S )-(+)-Dimethindene maleate
Brand: Tocris Bioscience
SKU: 1425
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1425

(2)

Citations (55)

COA / SDS

Selective M2 antagonist

Key Product Details

Description:	Selective M₂ antagonist
Chemical Name:	N,N-Dimethyl-3-[(1S)-1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine maleate
Purity:	≥99% (HPLC)
Molecular Weight:	408.5

View Full Technical Details for (S)-(+)-Dimethindene maleate

Technical Data
Citations / Reviews (2)

Biological Activity for (S)-(+)-Dimethindene maleate

(S)-(+)-Dimethindene maleate is an enantiomer that is a subtype-selective M₂ muscarinic receptor antagonist (pK_i values are 7.08, 7.78, 6.70 and 7.00 for M₁, M₂, M₃ and M₄ receptors respectively). Also H₁ histamine receptor antagonist (pK_i = 7.48). Allows formation of extended pluripotent stem (EPS) cells in combination with CHIR 99021 (Cat.No. 4423), minocycline hydrochloride (Cat.No. 3268) and human leukemia inhibitory factor.

For more information about how Dimethindene maleate may be used, see our protocol: Generation and Propagation of EPS cells (LCDM Cocktail).

Technical Data for (S)-(+)-Dimethindene maleate

M. Wt	408.5
Formula	C₂₀H₂₄N₂.C₄H₄O₄
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	136152-65-3
PubChem ID	56972160
InChi Key	SWECWXGUJQLXJF-HFNHQGOYSA-N
Smiles	C[C@H](C3=NC=CC=C3)C2=C(CCN(C)C)CC1=CC=CC=C12.OC(=O)\C=C/C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (S)-(+)-Dimethindene maleate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	29.24	100 with gentle warming

Preparing Stock Solutions for (S)-(+)-Dimethindene maleate

The following data is based on the product molecular weight 408.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.45 mL	12.24 mL	24.48 mL
5 mM	0.49 mL	2.45 mL	4.90 mL
10 mM	0.24 mL	1.22 mL	2.45 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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Reconstitution Calculator

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References for (S)-(+)-Dimethindene maleate

References are publications that support the biological activity of the product.

Pfaff The (S)-(+)-enantiomer of dimethindene: a novel M₂-selective muscarinic receptor antagonist. Eur.J.Pharmacol. 1995 PMID: 8608784
Yang Derivation of pluripotent stem cells with in vivo embryonic and extraembryonic potency. Cell. 2017 PMID: 28388409
Lambrecht Neuronal soma-dendritic and prejunctional M₁-M₄ receptors in gastrointestinal and genitourinary smooth muscle. Life Sci. 1999 PMID: 10069503