Reversan

Name: Reversan
Brand: Tocris Bioscience
SKU: 3722

Catalog # 3722 | Tocris Bioscience a Bio-Techne Brand

Citations (1)

COA / SDS

Selective MRP1 and P-gp inhibitor

Key Product Details

Description:	Selective MRP1 and P-gp inhibitor
Chemical Name:	N-[3-(4-Morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
Purity:	≥95% (HPLC)
Molecular Weight:	441.52

View Full Technical Details for Reversan

Technical Data
Citations (1) / Reviews

Biological Activity for Reversan

Reversan is a selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin (Cat. No. 2252), vincristine (Cat. No. 1257) and etoposide (Cat. No. 1226) by 3.8-, 14.6- and 11.6-fold respectively. Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo. Does not sensitize MRP2, MRP3, MRP4 or MRP5 transporters to known substrates.

Compound Libraries for Reversan

Reversan is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Reversan

M. Wt	441.52
Formula	C₂₆H₂₇N₅O₂
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	313397-13-6
PubChem ID	2298706
InChi Key	JTRXWCLQFAZHGP-UHFFFAOYSA-N
Smiles	O=C(NCCCN5CCOCC5)C2=C1N=C(C4=CC=CC=C4)C=C(C3=CC=CC=C3)N1N=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Reversan

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	11.04	25

Preparing Stock Solutions for Reversan

The following data is based on the product molecular weight 441.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	9.06 mL	45.30 mL	90.60 mL
1.25 mM	1.81 mL	9.06 mL	18.12 mL
2.5 mM	0.91 mL	4.53 mL	9.06 mL
12.5 mM	0.18 mL	0.91 mL	1.81 mL

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References for Reversan

References are publications that support the biological activity of the product.

Burkhart Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma. Cancer Res. 2009 PMID: 19654298

Citations for Reversan (1)

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Citations are publications that use Bio-Techne products. Selected citations for Reversan include:

James E et al. (2020) Roles of ABCC1 and ABCC4 in Proliferation and Migration of Breast Cancer Cell Lines. Int J Mol Sci. 21
PMID: 33081264

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