Etoposide
Tocris Bioscience, part of Bio-Techne | Catalog # 1226
Topoisomerase II inhibitor
Product Description
Etoposide is a DNA topoisomerase II inhibitor (IC50 = 59.2 μM). Anticancer. Also enhances adeno-associated virus (AAV) transduction of HeLa cells.Product Specifications
Molecular Weight
588.56
Formula
C29H32O13
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
[5R-[5α,5aβ,8aα,9β(R*)]]-9-[(4,6-Ο-Ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furonaphtho[2,3-d]-1,3-dioxol-6-(5aH)-one
CAS Number
33419-42-0
PubChem ID
36462
InChI Key
VJJPUSNTGOMMGY-MRVIYFEKSA-N
SMILES
OC(C(OC)=C3)=C(OC)C=[C@@]3[C@@H]2C1=CC6=C(OCO6)C=C1[C@@H](O[C@]4([H])O[C@@](CO[C@@H](C)O7)([H])[C@]7([H])[C@H](O)[C@H]4O)[C@@H]5[C@@H]2[C@](OC5)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 58.86 | 100 |
Preparing Stock Solutions
for Etoposide
The following data is based on the product molecular weight 588.56
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.70 mL | 8.50 mL | 16.99 mL |
| 5 mM | 0.34 mL | 1.70 mL | 3.40 mL |
| 10 mM | 0.17 mL | 0.85 mL | 1.70 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.34 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Nicolson Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens. J.Virol. 2016 PMID: 27147738
- Hande Etoposide: four decades of development of a topoisomerase II inhibitor. Eur.J.Cancer 1998 PMID: 9893622
- Terada Antitumor agents.3.Synthesis and biological activity of 4β-alkyl derivatives containing hydroxy, amino, and amido groups of 4'-O-demethyl-4-desoxypodophyllotoxin as antitumor agents. J.Med.Chem. 1993 PMID: 8389875
- Burden Toposiomerase II.etoposide interactions direct the formation of drug-induced enzyme-DNA cleavage complexes. J.Biol.Chem. 1996 PMID: 8910583
Product Specific Notices for Etoposide
For research use only
⚠ WARNING: This product can expose you to chemicals including Etoposide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov
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