Etoposide

Name: Etoposide
Brand: Tocris Bioscience
SKU: 1226
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 1226

Citations (4)

(1)

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Key Product Details

Description:	Topoisomerase II inhibitor
Chemical Name:	[5R-[5α,5aβ,8aα,9β(R*)]]-9-[(4,6-Ο-Ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6-(5aH)-one
Purity:	≥99% (HPLC)
Molecular Weight:	588.56

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Biological Activity for Etoposide

Etoposide is a DNA topoisomerase II inhibitor (IC₅₀ = 59.2 μM). Anticancer. Also enhances adeno-associated virus (AAV) transduction of HeLa cells.

Compound Libraries for Etoposide

Etoposide is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library, Tocriscreen Epigenetics Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Etoposide

M. Wt	588.56
Formula	C₂₉H₃₂O₁₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	33419-42-0
PubChem ID	36462
InChi Key	VJJPUSNTGOMMGY-MRVIYFEKSA-N
Smiles	OC(C(OC)=C3)=C(OC)C=[C@@]3[C@@H]2C1=CC6=C(OCO6)C=C1[C@@H](O[C@]4([H])O[C@@](CO[C@@H](C)O7)([H])[C@]7([H])[C@H](O)[C@H]4O)[C@@H]5[C@@H]2[C@](OC5)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Etoposide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	58.86	100

Preparing Stock Solutions for Etoposide

The following data is based on the product molecular weight 588.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.70 mL	8.50 mL	16.99 mL
5 mM	0.34 mL	1.70 mL	3.40 mL
10 mM	0.17 mL	0.85 mL	1.70 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

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References for Etoposide

References are publications that support the biological activity of the product.

Nicolson Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens. J.Virol. 2016 PMID: 27147738
Hande Etoposide: four decades of development of a topoisomerase II inhibitor. Eur.J.Cancer 1998 PMID: 9893622
Burden Toposiomerase II.etoposide interactions direct the formation of drug-induced enzyme-DNA cleavage complexes. J.Biol.Chem. 1996 PMID: 8910583
Terada Antitumor agents.3.Synthesis and biological activity of 4β-alkyl derivatives containing hydroxy, amino, and amido groups of 4'-O-demethyl-4-desoxypodophyllotoxin as antitumor agents. J.Med.Chem. 1993 PMID: 8389875

Citations for Etoposide (4)

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Citations are publications that use Bio-Techne products. Selected citations for Etoposide include:

Long et al. (2019) Novel peptide dermaseptin-PS1 exhibits anticancer activity via induction of intrinsic apoptosis signalling. J Cell Mol Med. 23:1300
PMID: 30461197
Maswadeh et al. (2015) Etoposide incorporated into camel milk phospholipids liposomes shows increased activity against fibrosarcoma in a mouse model. Eur J Cancer. 2015:743051
PMID: 25821817
Nicolson (2014) Recombinant adeno-associated virus utilizes host cell nuclear import machinery to enter the nucleus. J Virol. 88:4132
PMID: 24478436
Li et al. (2013) Transmembrane Protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase 4 enzyme activation and apoptosis. J Biol Chem. 288:17908
PMID: 23661706

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Etoposide inhibits growth of melanoma cell line at micromolar concentrations

Name: Anonymous

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: SK-MEL-28

Used for killing assay for in vitro cell culture. Cells were cultured for 24 hours before the addition of the compound into the media at low micromolar concentrations (indicated by the arrow).

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Product Documents for Etoposide

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Etoposide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov