(+)-U-50488 hydrochloride

Name: (+)-U-50488 hydrochloride
Brand: Tocris Bioscience
SKU: 0471
Rating: 4 (1 reviews)

Catalog # 0471

(1)

COA / SDS

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Bio-Techne Corporation

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Key Product Details

Description:	Selective κ agonist; less active enantiomer of (±)-U-50488 (Cat. No. 0495)
Chemical Name:	trans-(+)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	405.79

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Biological Activity

(+)-U-50488 hydrochloride is a less active enantiomer of (±)-U-50488.

Racemate and (-)-enantiomer also available.

Technical Data

M. Wt	405.79
Formula	C₁₉H₂₆Cl₂N₂O.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	114528-81-3
PubChem ID	6918162
InChi Key	KGMMGVIYOHGOKQ-JAXOOIEVSA-N
Smiles	O=C(CC3=CC(Cl)=C(Cl)C=C3)N([C@H]1[C@H](N2CCCC2)CCCC1)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	40.58	100
	DMSO	40.58	100

Preparing Stock Solutions

The following data is based on the product molecular weight 405.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.32 mL	24.64 mL
5 mM	0.49 mL	2.46 mL	4.93 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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References

References are publications that support the biological activity of the product.

De Costa Synthesis and absolute configuration of optically pure enantiomers of a κ-opioid receptor selective antagonist. FEBS Lett. 1987 PMID: 2822490

Citations for (+)-U-50488 hydrochloride

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Good product

Name: Luca Zangrandi

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: CHO

Successfully induced ERK phosphorylation in CHO cells. Somehow weaker signal compared to other enantiomer.

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