(-)-U-50488 hydrochloride

Name: (-)-U-50488 hydrochloride
Brand: Tocris Bioscience
SKU: 0496
Rating: 5 (3 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0496

(3)

Citations (21)

COA / SDS

Selective κ agonist; more active enantiomer of (±)-U-50488 (Cat. No. 0495)

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Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Selective κ agonist; more active enantiomer of (±)-U-50488 (Cat. No. 0495)

View all Kappa Opioid Receptor Agonists »

Product Description

(-)-U-50488 hydrochloride is a more active enantiomer of (±)-U-50488.

Racemate and (+)-enantiomer also available.

Product Specifications

Molecular Weight

405.79

Formula

C₁₉H₂₆Cl₂N₂O.HCl

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride

CAS Number

114528-79-9

PubChem ID

9931141

InChI Key

KGMMGVIYOHGOKQ-APTPAJQOSA-N

SMILES

O=C(CC3=CC(Cl)=C(Cl)C=C3)N([C@@H]1[C@@H](N2CCCC2)CCCC1)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	8.12	20
	DMSO	40.58	100

Preparing Stock Solutions for (-)-U-50488 hydrochloride

The following data is based on the product molecular weight 405.79

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.32 mL	24.64 mL
5 mM	0.49 mL	2.46 mL	4.93 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

Calculators

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

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Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Zhu Agonist-induced desensitization and down-regulation of the human kappa opioid receptor expressed in chinese hamster ovary cells. J.Pharmacol.Exp.Ther. 1998 PMID: 9535991
Morrone Withdrawal contractures of guinea-pig isolated ileum after acute activation of κ opioid receptors. Br.J.Pharmacol. 1993 PMID: 8388301
Reddy and Bhargava Effect of chronic administration of U-50,488H, a kappa opioid receptor agonist on central DA (D₂) receptors of the rat. Eur.J.Pharmacol. 1993 PMID: 8390939
De Costa Synthesis and absolute configuration of optically pure enantiomers of a κ-opioid receptor selective antagonist. FEBS Lett. 1987 PMID: 2822490