(±)-U-50488 hydrochloride
Tocris Bioscience a Bio-Techne Brand
Key Product Details
Description: | Selective κ agonist |
Chemical Name: | trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 405.79 |
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Citations for (±)-U-50488 hydrochloride (9)
Citations are publications that use Bio-Techne products. Selected citations for (±)-U-50488 hydrochloride include:
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Pirino et al.
(2020)
Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis
Neuropharmacology.
181:108341
PMID: 33011200 -
Li et al.
(2019)
Kappa opioid receptor agonists improve postoperative cognitive dysfunction in rats via the JAK2/STAT3 signaling pathway.
Int J Mol Med.
2019;
PMID: 31545485 -
Liu
(2018)
In vivo brain GPCR signaling elucidated by phosphoproteomics.
Science.
360(6395):eaao4927
PMID: 29930108 -
Dziedowiec et al.
(2018)
sMu opioid receptor agonist DAMGO produces place conditioning, abstinence-induced withdrawal, and naltrexone-dependent locomotor activation in planarians.
Neuroscience.
386:214
PMID: 29958944 -
Polter
(2017)
Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapsesfollowing acute stress
Elife.
6:e23785
PMID: 28402252 -
Zhou et al.
(2013)
Development of functionally selective, small molecule agonists at kappa opioid receptors.
J Biol Chem.
288:36703
PMID: 24187130 -
Kharmate et al.
(2013)
Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells.
Cancer Cell Int.
13:93
PMID: 24059654 -
Grachev et al.
(2012)
GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats.
Pain.
7:e44344
PMID: 23028524 -
Marchant et al.
(2010)
Medial dorsal hypothalamus mediates the inhibition of reward seeking after extinction.
J Neurosci.
30:14102
PMID: 20962231
There are no citations that match your criteria.
Customer Reviews for (±)-U-50488 hydrochloride (4)
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Species: HumanAssay Type: In VitroDose response curve of beta arrestin recruitment (Presto_Tango assay)
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Species: RatAssay Type: In VivoCell Line/Tissue: brainU50488 (5 mg/kg) injection
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Species: HumanAssay Type: In VitroCell Line/Tissue: CHOSuccessfully induced ERK1/2 phosphorylation in CHO cells expressing KOR.
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Species: RatAssay Type: In VivoTo evaluate the behavioral effects of unbiased and biased kappa agonists in animalssoluble in water up to 5.6 mg/mL
There are no reviews that match your criteria.