(±)-U-50488 hydrochloride

Name: (±)-U-50488 hydrochloride
Brand: Tocris Bioscience
SKU: 0495
Rating: 5 (4 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0495

(4)

Citations (21)

COA / SDS

Selective κ agonist

Key Product Details

Description:	Selective κ agonist
Chemical Name:	trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	405.79

View Full Technical Details for (±)-U-50488 hydrochloride

Technical Data
Citations / Reviews (4)

Biological Activity for (±)-U-50488 hydrochloride

(±)-U-50488 hydrochloride is a selective κ-opioid agonist. At higher concentrations blocks Na⁺ channels.

(-)-enantiomer and (+)-enantiomer also available.

Technical Data for (±)-U-50488 hydrochloride

M. Wt	405.79
Formula	C₁₉H₂₆Cl₂N₂O.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	67197-96-0
PubChem ID	90479733
InChi Key	SKWPJQQGGZWRSK-PXOXCKTNSA-N
Smiles	O=C(CC3=CC(Cl)=C(Cl)C=C3)N([C@H]1[C@H](N2CCCC2)CCCC1)C.O=C(CC6=CC(Cl)=C(Cl)C=C6)N([C@@H]4[C@@H](N5CCCC5)CCCC4)C.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (±)-U-50488 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	10.14	25

Preparing Stock Solutions for (±)-U-50488 hydrochloride

The following data is based on the product molecular weight 405.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	9.86 mL	49.29 mL	98.57 mL
1.25 mM	1.97 mL	9.86 mL	19.71 mL
2.5 mM	0.99 mL	4.93 mL	9.86 mL
12.5 mM	0.20 mL	0.99 mL	1.97 mL

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References for (±)-U-50488 hydrochloride

References are publications that support the biological activity of the product.

Su Blockade of the development of mor. tolerance by U-50,488, an AVP antagonist or MK 801 in the rat hippocampal slice. Br.J.Pharmacol. 1998 PMID: 9517380
Suarez-Roca and Maixner Activation of kappa opioid receptors by U-50488H and mor. enhances the release of substance P from rat trigeminal nucleus slices. J.Pharmacol.Exp.Ther. 1993 PMID: 7679733
Pugsley Cardiovascular actions of the κ-agonist, U-50-488H, in the absence and presence of opioid receptor blockade. Br.J.Pharmacol. 1992 PMID: 1320979
Pao-Luh Tao U-50,488 blocks the development of mor. tolerance and dependence at a very low dose in guinea pigs. Eur.J.Pharmacol. 1994 PMID: 8045272