(±)-U-50488 hydrochloride

Name: (±)-U-50488 hydrochloride
Brand: Tocris Bioscience
SKU: 0495
Rating: 5 (4 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0495

(4)

Citations (20)

COA / SDS

Selective κ agonist

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Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Selective κ agonist

View all Kappa Opioid Receptor Agonists »

Product Description

(±)-U-50488 hydrochloride is a selective κ-opioid agonist. At higher concentrations blocks Na⁺ channels.

(-)-enantiomer and (+)-enantiomer also available.

Product Specifications

Molecular Weight

405.79

Formula

C₁₉H₂₆Cl₂N₂O.HCl

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride

CAS Number

67197-96-0

PubChem ID

90479733

InChI Key

SKWPJQQGGZWRSK-PXOXCKTNSA-N

SMILES

O=C(CC3=CC(Cl)=C(Cl)C=C3)N([C@H]1[C@H](N2CCCC2)CCCC1)C.O=C(CC6=CC(Cl)=C(Cl)C=C6)N([C@@H]4[C@@H](N5CCCC5)CCCC4)C.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	10.14	25

Preparing Stock Solutions for (±)-U-50488 hydrochloride

The following data is based on the product molecular weight 405.79

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	9.86 mL	49.29 mL	98.57 mL
1.25 mM	1.97 mL	9.86 mL	19.71 mL
2.5 mM	0.99 mL	4.93 mL	9.86 mL
12.5 mM	0.20 mL	0.99 mL	1.97 mL

Calculators

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

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Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Su Blockade of the development of mor. tolerance by U-50,488, an AVP antagonist or MK 801 in the rat hippocampal slice. Br.J.Pharmacol. 1998 PMID: 9517380
Suarez-Roca and Maixner Activation of kappa opioid receptors by U-50488H and mor. enhances the release of substance P from rat trigeminal nucleus slices. J.Pharmacol.Exp.Ther. 1993 PMID: 7679733
Pugsley Cardiovascular actions of the κ-agonist, U-50-488H, in the absence and presence of opioid receptor blockade. Br.J.Pharmacol. 1992 PMID: 1320979
Pao-Luh Tao U-50,488 blocks the development of mor. tolerance and dependence at a very low dose in guinea pigs. Eur.J.Pharmacol. 1994 PMID: 8045272