Jasplakinolide

Tocris Bioscience, part of Bio-Techne | Catalog # 2792

Stabilizes F-actin; promotes actin polymerization
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Key Product Details

Description

Stabilizes F-actin; promotes actin polymerization

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Product Description

Jasplakinolide rapidly stabilizes pre-formed actin filaments and inhibits their disassembly in vitro. Also induces polymerization of actin monomers into F-actin in vivo. Shown to bind to F-actin competitively with phalloidin (Cat. No. 4535) (Kd ~ 15 nM). Exhibits antifungal and antiproliferative effects (IC50 = 35 nM for antiproliferative activity in PC3 cells). Cell permeable.

Product Specifications

Molecular Weight

709.67

Formula

C36H45BrN4O6

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

Cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl]

CAS Number

102396-24-7

PubChem ID

9831636

InChI Key

GQWYWHOHRVVHAP-DHKPLNAMSA-N

SMILES

C[C@H](C[C@H](C)OC1=O)/C=C(C)/C[C@H](C)C(N[C@H](C(N([C@H](CC2=C(Br)NC3=C2C=CC=C3)C(N[C@@H]([C@]4=CC=C(O)C=C4)C1)=O)C)=O)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2

Preparing Stock Solutions for Jasplakinolide

The following data is based on the product molecular weight 709.67

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.03 mM 46.97 mL 234.85 mL 469.70 mL
0.15 mM 9.39 mL 46.97 mL 93.94 mL
0.3 mM 4.70 mL 23.49 mL 46.97 mL
1.5 mM 0.94 mL 4.70 mL 9.39 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Jasplakinolide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Jasplakinolide

For research use only

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