ISO 1

Tocris Bioscience, part of Bio-Techne | Catalog # 4288

Macrophage migration inhibitory factor (MIF) inhibitor
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Key Product Details

Description

Macrophage migration inhibitory factor (MIF) inhibitor

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Product Description

ISO 1 is a macrophage migration inhibitory factor (MIF) inhibitor (IC50 = 7 μM); inhibits MIF tautomerase activity in vitro and in vivo. Protective against mouse models of streptozotocin-induced diabetes mellitus; blocks anti-inflammatory response following LPS exposure and increases survival. Inhibits airway remodeling in a mouse model of chronic asthma. Cell permeable; orally bioavailable.

Product Specifications

Molecular Weight

235.24

Formula

C12H13NO4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

4,5-Dihydro-3-(4-hydroxyphenyl)-5-isoxazoleacetic acid methyl ester

CAS Number

478336-92-4

PubChem ID

6098948

InChI Key

CLVQGFPQFNASJH-UHFFFAOYSA-N

SMILES

OC(C=C2)=CC=C2C1=NOC(CC(OC)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.52 100
Ethanol 23.52 100

Preparing Stock Solutions for ISO 1

The following data is based on the product molecular weight 235.24

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.25 mL 21.25 mL 42.51 mL
5 mM 0.85 mL 4.25 mL 8.50 mL
10 mM 0.43 mL 2.13 mL 4.25 mL
50 mM 0.09 mL 0.43 mL 0.85 mL

Calculators

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Reconstitution Calculator

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Product Documents for ISO 1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ISO 1

For research use only

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