iFSP1
Tocris Bioscience, part of Bio-Techne | Catalog # 7162
Ferroptosis suppressor protein 1 (FSP1) inhibitor; ferroptosis inducer
Key Product Details
Description
Ferroptosis suppressor protein 1 (FSP1) inhibitor; ferroptosis inducer
Product Description
iFSP1 is a ferroptosis inducer. Inhibits ferroptosis suppressor protein 1 (FSP1) and induces ferroptosis in GPX4 knockout cells. Sensitizes tumor cells to RSL3 (Cat. No. 6118) -induced ferroptosis.Product Specifications
Molecular Weight
323.36
Formula
C20H13N5
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-Amino-3-(4-methylphenyl)-pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile
CAS Number
150651-39-1
PubChem ID
699043
InChI Key
FNESYDFRCQEEKA-UHFFFAOYSA-N
SMILES
CC1=CC=C(C2=C(C#N)C3=NC4=CC=CC=C4N3C(N)=C2C#N)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.47 | 20 |
Preparing Stock Solutions
for iFSP1
The following data is based on the product molecular weight 323.36
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 15.46 mL | 77.31 mL | 154.63 mL |
| 1 mM | 3.09 mL | 15.46 mL | 30.93 mL |
| 2 mM | 1.55 mL | 7.73 mL | 15.46 mL |
| 10 mM | 0.31 mL | 1.55 mL | 3.09 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bersuker The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature 2019 PMID: 31634900
Product Specific Notices for iFSP1
For research use only
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