HHP 9
Tocris Bioscience, part of Bio-Techne | Catalog # 7828
BET bromodomain Degrader (PROTAC®); also potent Hedgehog pathway inhibitor
Key Product Details
Description
BET bromodomain Degrader (PROTAC®); also potent Hedgehog pathway inhibitor
Product Description
HHP 9 is a potent BET bromodomain Degrader (PROTAC®; DC50 values are 0.03 μM, 0.2 μM and 0.2 μM at BRD3, BRD2 and BRD4 respectively). BRD2, BRD3 and BRD4 are almost completely degraded by HHP 9 in vitro (after 27h incubation with 0.5 - 5 μM of HHP 9). Comprises a Hedgehog Pathway Inhibitor-1 (HPI-1, Cat. No. 3839) coupled to a CRBN ligand. BET bromodomain degradation through HPP-9 results in long-acting Hh pathway inhibition.PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Product Specifications
Molecular Weight
900.99
Formula
C49H52N6O11
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-Methoxyethyl 4-(3-((1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
CAS Number
3093738-79-2
InChI Key
RJNFQVDPIFXYAO-UHFFFAOYSA-N
SMILES
CC1=C(C(OCCOC)=O)C(C2=CC(OCC3=CN(CCCCCCOC4=CC=CC(C(N5C6CCC(NC6=O)=O)=O)=C4C5=O)N=N3)=CC=C2)C7=C(N1)CC(C8=C(OC)C=CC=C8)CC7=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 90.1 | 100 |
Preparing Stock Solutions
for HHP 9
The following data is based on the product molecular weight 900.99
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.11 mL | 5.55 mL | 11.10 mL |
| 5 mM | 0.22 mL | 1.11 mL | 2.22 mL |
| 10 mM | 0.11 mL | 0.55 mL | 1.11 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.22 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bagka Targeted protein degradation reveals BET bromodomains as the cellular target of Hedgehog pathway inhibitor-1. Nat.Commun. 2023 PMID: 37393376
Product Specific Notices for HHP 9
For research use only
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