Fexofenadine hydrochloride

Name: Fexofenadine hydrochloride
Brand: Tocris Bioscience
SKU: 2429

Tocris Bioscience, part of Bio-Techne | Catalog # 2429

Citations (14)

COA / SDS

H1 receptor antagonist; non-sedating antiallergic agent

Discontinued Product

2429 has been discontinued. View all Histamine H1 Receptor Antagonists products.

Key Product Details

Description:	H₁ receptor antagonist; non-sedating antiallergic agent
Alternative Names:	MDL 16455,Terfenidine
Chemical Name:	α,α-Dimethyl-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-benzeneacetic acid hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	538.12

View Full Technical Details for Fexofenadine hydrochloride

Technical Data
Citations

Biological Activity for Fexofenadine hydrochloride

Fexofenadine hydrochloride is a selective histamine H₁ receptor antagonist (pK_i = 8.1). Active metabolite of Terfenadine (Cat. No. 3948) that displays non-sedating antiallergic effects. Fexofenadine hydrochloride counteracts histamine mediated immune suppression and improves immunotherapy response.

Compound Libraries for Fexofenadine hydrochloride

Fexofenadine hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Fexofenadine hydrochloride

M. Wt	538.12
Formula	C₃₂H₃₉NO₄.HCl
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	153439-40-8
PubChem ID	63002
InChi Key	RRJFVPUCXDGFJB-UHFFFAOYSA-N
Smiles	Cl.CC(C)(C(O)=O)C1=CC=C(C=C1)C(O)CCCN1CCC(CC1)C(O)(C1=CC=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Fexofenadine hydrochloride

References are publications that support the biological activity of the product.

Li The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1. Cancer Cell 2022 PMID: 34822775
Sakairi Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis. Pharmacology 2005 PMID: 16037679
Gillard and Chatelaine Changes in pH differently affect the binding properties of histamine H₁ receptor antagonists. Eur.J.Pharmacol. 2006 PMID: 16388798
Markham and Wagstaff Fexofenadine. Drugs 1998 PMID: 9506246