EM12-SO₂F

Name: EM12-SO 2 F
Brand: Tocris Bioscience
SKU: 7852

Tocris Bioscience, part of Bio-Techne | Catalog # 7852

COA / SDS

Potent covalent inhibitor of Cereblon

Key Product Details

Description:	Potent covalent inhibitor of Cereblon
Chemical Name:	2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-3-oxo-1H-isoindole-5-sulfonyl fluoride
Purity:	≥95% (HPLC)
Molecular Weight:	326.3

View Full Technical Details for EM12-SO₂F

Technical Data
Citations

Biological Activity for EM12-SO₂F

EM12-SO₂F is a potent covalent Cereblon (CRBN) inhibitor (IC₅₀ = 0.88 nM). Binds to a histidine residue (His353) in the IMiD binding pocket of CRBN and blocks the recruitment of its substrates. EM12-SO₂F prevents Lenalidomide (Cat. No. 6305)-induced degradation of the zinc finger transcription factor IKZF1 in MOLT4 cells. It complements CRBN based PROTAC and genetic methods to validate CRBN-mediated degradation.

Technical Data for EM12-SO₂F

M. Wt	326.3
Formula	C₁₃H₁₁FN₂O₅S
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2803819-61-4
PubChem ID	165670019
InChi Key	IAJNULNMWPZFDR-UHFFFAOYSA-N
Smiles	O=C1NC(C(CC1)N2C(C3=CC(S(=O)(F)=O)=CC=C3C2)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for EM12-SO₂F

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	32.63	100

Preparing Stock Solutions for EM12-SO₂F

The following data is based on the product molecular weight 326.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.06 mL	15.32 mL	30.65 mL
5 mM	0.61 mL	3.06 mL	6.13 mL
10 mM	0.31 mL	1.53 mL	3.06 mL
50 mM	0.06 mL	0.31 mL	0.61 mL

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Reconstitution Calculator

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References for EM12-SO₂F

References are publications that support the biological activity of the product.

Cruite Cereblon covalent modulation through structure-based design of histidine targeting chemical probes. RSC Chem.Biol. 2022 PMID: 36128501

EM12-SO₂F

Tocris Bioscience, part of Bio-Techne | Catalog # 7852

Key Product Details

Biological Activity for EM12-SO₂F

Technical Data for EM12-SO₂F

Solubility for EM12-SO₂F

Preparing Stock Solutions for EM12-SO₂F

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for EM12-SO₂F

Product Documents for EM12-SO₂F

COA

Certificate of Analysis

SDS

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EM12-SO2F

Tocris Bioscience, part of Bio-Techne | Catalog # 7852

Key Product Details

Biological Activity for EM12-SO2F

Technical Data for EM12-SO2F

Solubility for EM12-SO2F

Preparing Stock Solutions for EM12-SO2F

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for EM12-SO2F

Product Documents for EM12-SO2F

COA

Certificate of Analysis

SDS

EM12-SO₂F

Biological Activity for EM12-SO₂F

Technical Data for EM12-SO₂F

Solubility for EM12-SO₂F

Preparing Stock Solutions for EM12-SO₂F

References for EM12-SO₂F

Product Documents for EM12-SO₂F