Cytochalasin D is a potent disruptor of actin filament function. Alters tight junction permeability. Unlike cytochalasin B (Cat. No. 5474), does not inhibit monosaccharide transport across the plasma membrane.

Product Specifications

Molecular Weight

507.63

Formula

C₃₀H₃₇NO₆

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

(7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione

CAS Number

22144-77-0

PubChem ID

98137101

InChI Key

SDZRWUKZFQQKKV-HYKYWQBKSA-N

SMILES

C=C([C@H]4C)[C@@H](O)[C@]([C@@]1([C@H](OC(C)=O)/C=C/[C@@](O)3C)[C@]4([H])[C@@H](CC2=CC=CC=C2)N[C@]1=O)([H])/C=C/C[C@H](C)C3=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	25
	Ethanol	5	with gentle warming

Preparing Stock Solutions for Cytochalasin D

The following data is based on the product molecular weight 507.63

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.94 mL	19.70 mL	39.40 mL
2.5 mM	0.79 mL	3.94 mL	7.88 mL
5 mM	0.39 mL	1.97 mL	3.94 mL
25 mM	0.08 mL	0.39 mL	0.79 mL

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Background References

References are publications that support the biological activity of the product.

Carlier Interaction of cytochalasin D with actin filaments in the presence of ADP and ATP. J.Biol.Chem. 1986 PMID: 3944126
Stevenson and Begg Concentration-dependent effects of cytochalasin D on tight junctions and actin filaments in MDCK epithelial cells. J.Cell Sci. 1994 PMID: 8006058
Abedi and Zachary Cytochalasin D stimulation of tyrosine phosphorylation and phosphotyrosine-associated kinase activity in vascular smooth muscle cells. Biochem.Biophys.Res.Commun. 1998 PMID: 9588169

Cytochalasin D

Tocris Bioscience, part of Bio-Techne | Catalog # 1233

Key Product Details

Description

Alternative Names

View all Actin-related Products »

Product Description