Cytochalasin B

Name: Cytochalasin B
Brand: Tocris Bioscience
SKU: 5474

Tocris Bioscience a Bio-Techne Brand

Catalog # 5474

Citations (2)

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Key Product Details

Description:	Inhibitor of actin polymerization
Chemical Name:	(3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-6,7,8,9,10,12a,13,14,15,15a,16,17-Dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
Purity:	≥98% (HPLC)
Molecular Weight:	479.61

View Full Technical Details for Cytochalasin B

Biological Activity for Cytochalasin B

Cytochalasin B is an inhibitor of actin polymerization. Inhibits cell division, migration and glucose transport. Causes G₂/M cell cycle arrest and apoptosis in HCT-116 colorectal carcinoma cells. Cell permeable.

Technical Data for Cytochalasin B

M. Wt	479.61
Formula	C₂₉H₃₇NO₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	14930-96-2
PubChem ID	5311281
InChi Key	GBOGMAARMMDZGR-TYHYBEHESA-N
Smiles	C=C([C@H]1C)[C@@H](O)[C@]([C@@]2(O3)[C@]1([H])[C@H](CC4=CC=CC=C4)NC2=O)([H])/C=C/C[C@H](C)CCC[C@@H](O)/C=C/C3=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cytochalasin B

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.8	10 with gentle warming

Preparing Stock Solutions for Cytochalasin B

The following data is based on the product molecular weight 479.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.85 mL	104.25 mL	208.50 mL
0.5 mM	4.17 mL	20.85 mL	41.70 mL
1 mM	2.09 mL	10.43 mL	20.85 mL
5 mM	0.42 mL	2.09 mL	4.17 mL

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References for Cytochalasin B

References are publications that support the biological activity of the product.

Buldak Changes in subcellular localization of visfatin in human colorectal HCT-116 carcinoma cell line after cytochalasin B treatment. Eur.J.Histochem. 2014 PMID: 25308845
Whitesell Compartmentalization of transport and phosphorylation of glucose in a hepatoma cell line. Biochem.J. 2005 PMID: 15473866
Theodoropoulos Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping. Biochem.Pharmacol. 1994 PMID: 8204105

Citations for Cytochalasin B (2)

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Citations are publications that use Bio-Techne products. Selected citations for Cytochalasin B include:

Bernier et al. (2019) Nanoscale Surveillance of the Brain by Microglia via cAMP-Regulated Filopodia. Cell Rep. 27:2895
PMID: 31167136
Diaz-Garcia et al. (2017) Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake. Cell Metab. 26:361
PMID: 28768175

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