Cyclosporin H
Tocris Bioscience, part of Bio-Techne | Catalog # 6982
Enhances lentiviral transduction
Key Product Details
Description
Enhances lentiviral transduction
Product Description
Cyclosporin H is a viral transduction enhancer. Increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Displays an additive effect when combined with rapamycin (Cat. No. 1292) or prostaglandin E2 (Cat. No. 2296). Lacks immunosuppressant activity of cyclosporin A (Cat. No. 1101).Product Specifications
Molecular Weight
1202.64
Formula
C62H111N11O12
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
5-(N-Methyl-D-valine)cyclosporin A
CAS Number
83602-39-5
PubChem ID
6476564
InChI Key
PMATZTZNYRCHOR-JLPRAAIDSA-N
SMILES
[H][C@]1(NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](CC)NC(=O)[C@]([H])([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@@]([H])(C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@]([H])(CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C1=O)C(C)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 120.26 | 100 | |
| Ethanol | 60.13 | 50 |
Preparing Stock Solutions
for Cyclosporin H
The following data is based on the product molecular weight 1202.64
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.83 mL | 4.16 mL | 8.32 mL |
| 5 mM | 0.17 mL | 0.83 mL | 1.66 mL |
| 10 mM | 0.08 mL | 0.42 mL | 0.83 mL |
| 50 mM | 0.02 mL | 0.08 mL | 0.17 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Petrillo Cyclosporine H overcomes innate immune restrictions to improve lentiviral transduction and gene editing in human hematopoietic stem cells. Cell Stem Cell. 2018 PMID: 30416070
Product Specific Notices for Cyclosporin H
For research use only
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