CLP 290
Tocris Bioscience, part of Bio-Techne | Catalog # 6758
K+/Cl- cotransporter 2 (KCC2) activator; orally bioavailable prodrug of CLP 257 (Cat. No.5242)
Key Product Details
Description
K+/Cl- cotransporter 2 (KCC2) activator; orally bioavailable prodrug of CLP 257 (Cat. No.5242)
Product Description
CLP 290 is a K+/Cl- Cotransporter 2 (KCC2) activator. Activates spinal inhibitory interneurons, restores physiological neuronal activity in the spinal cord and induces functional recovery in a mouse model of spinal cord injury. Also decreases blood vasopressin and glucose levels in mice with Streptozotocin (Cat. No. 1621) induced diabetes mellitus. Orally bioavailable prodrug of CLP 257 (Cat. No.5242).Product Specifications
Molecular Weight
404.46
Formula
C19H21FN4O3S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(Z)-5-Fluoro-2-((4-oxo-2-(tetrahydropyridazin-1(2H)-yl)thiazol-5(4H)-ylidene)methyl)phenyl pyrrolidine-1-carboxylate
CAS Number
1181083-81-7
PubChem ID
68637267
InChI Key
DIXMMXNNKLCLOM-WJDWOHSUSA-N
SMILES
FC1=CC(OC(N2CCCC2)=O)=C(C=C1)/C=C3SC(N4CCCCN4)=NC\3=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.22 | 50 | |
| Ethanol | 2.02 | 5 |
Preparing Stock Solutions
for CLP 290
The following data is based on the product molecular weight 404.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.94 mL | 24.72 mL | 49.45 mL |
| 2.5 mM | 0.99 mL | 4.94 mL | 9.89 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.94 mL |
| 25 mM | 0.10 mL | 0.49 mL | 0.99 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kim Long-term ionic plasticity of GABAergic signalling in the hypothalamus. J.Neuroendocrinol. 2019 PMID: 31166034
- Chen Reactivation of dormant relay pathways in injured spinal cord by KCC2 manipulations. Cell 2018 PMID: 30033363
- Gagnon Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat.Med. 2013 PMID: 24097188
Product Specific Notices for CLP 290
For research use only
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