CeMMEC1

Name: CeMMEC1
Brand: Tocris Bioscience
SKU: 7139

Tocris Bioscience, part of Bio-Techne | Catalog # 7139

COA / SDS

TAF1 inhibitor

Key Product Details

Description:	TAF1 inhibitor
Chemical Name:	N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-2-methyl-1-oxo-4-isoquinolinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	336.35

View Full Technical Details for CeMMEC1

Technical Data
Citations

Biological Activity for CeMMEC1

CeMMEC1 is a TAF1 inhibitor (Kd = 1.8 μM, IC₅₀ = 900 nM). CeMMEC1 impairs cell viability in combination with (+)-JQ1 (Cat. No. 4499) and inhibits proliferation of THP-1 and H23 lung adenocarcinoma cells.

Compound Libraries for CeMMEC1

CeMMEC1 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for CeMMEC1

M. Wt	336.35
Formula	C₁₉H₁₆N₂O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	440662-09-9
PubChem ID	24152379
InChi Key	PEOQAZBGLOADFJ-UHFFFAOYSA-N
Smiles	CN1C=C(C(=O)NC2=CC=C3OCCOC3=C2)C2=CC=CC=C2C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CeMMEC1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	33.63	100

Preparing Stock Solutions for CeMMEC1

The following data is based on the product molecular weight 336.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.97 mL	14.87 mL	29.73 mL
5 mM	0.59 mL	2.97 mL	5.95 mL
10 mM	0.30 mL	1.49 mL	2.97 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

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References for CeMMEC1

References are publications that support the biological activity of the product.

Sdelci Mapping the chemical chromatin reactivation landscape identifies BRD 4-TAtaF1 cross-talk. Nat.Chem.Biol. 2016 PMID: 27159579