α-Synuclein Degrader 2b
Tocris Bioscience, part of Bio-Techne | Catalog # 8040
α-synuclein Degrader (PROTAC®)
Product Description
α-Synuclein Degrader 2b is a selective α-synuclein Degrader (PROTAC®) (DC50 = 7.5 μM; Dmax = 89%). Comprises the probe molecule sery308, joined by a linker to a pomalidomide E3 ligase ligand. Activates both proteasomal and lysosomal degradation pathways. Protects SH-SY5Y cells from α-synuclein-induced cytotoxicity. Cell permeable.PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Product Specifications
Molecular Weight
767.80
Formula
C39H41N7O10
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[[3-[5-(1,3-Benzodioxol-5-yl)-1H-pyrazol-3-yl]phenyl]amino]-N-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]acetamide
CAS Number
2781922-42-5
InChI Key
IYFKRANQUJUTKF-UHFFFAOYSA-N
SMILES
O=C(CNC1=CC=CC(C2=NNC(C3=CC4=C(OCO4)C=C3)=C2)=C1)NCCOCCOCCOCCNC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 76.78 | 100 |
Preparing Stock Solutions
for α-Synuclein Degrader 2b
The following data is based on the product molecular weight 767.80
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.30 mL | 6.51 mL | 13.02 mL |
| 5 mM | 0.26 mL | 1.30 mL | 2.60 mL |
| 10 mM | 0.13 mL | 0.65 mL | 1.30 mL |
| 50 mM | 0.03 mL | 0.13 mL | 0.26 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Tong Discovery of small-molecule degraders for alpha-synuclein aggregates. J.Med.Chem. 2023 PMID: 37267712
Product Specific Notices for α-Synuclein Degrader 2b
For research use only
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