(-)-[3R,4S]-Chromanol 293B

Name: (-)-[3 R ,4 S ]-Chromanol 293B
Brand: Tocris Bioscience
SKU: 1475

Tocris Bioscience, part of Bio-Techne | Catalog # 1475

Citations (8)

COA / SDS

IKs blocker. Enantiomer of Chromanol 293B (Cat. No. 1412)

Key Product Details

Description:	I_Ks blocker. Enantiomer of Chromanol 293B (Cat. No. 1412)
Chemical Name:	N-[(3R,4S)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methylethanesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	324.39

View Full Technical Details for (-)-[3R,4S]-Chromanol 293B

Technical Data
Citations

Biological Activity for (-)-[3R,4S]-Chromanol 293B

(-)-[3R,4S]-Chromanol 293B is a enantiomer that selectively inhibits the slow component of delayed rectifier K⁺ current (I_Ks). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC₅₀ values are 1.36 and 9.6 μM respectively). Has negligible inhibitory action at K_V11.1 (hERG) channels (IC₅₀ > 30 μM).

Racemate also available.

Compound Libraries for (-)-[3R,4S]-Chromanol 293B

(-)-[3R,4S]-Chromanol 293B is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for (-)-[3R,4S]-Chromanol 293B

M. Wt	324.39
Formula	C₁₅H₂₀N₂O₄S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	163163-24-4
PubChem ID	121846
InChi Key	HVSJHHXUORMCGK-UONOGXRCSA-N
Smiles	CCS(=O)(=O)N(C)[C@@H]1[C@@H](O)C(C)(C)OC2=C1C=C(C=C2)C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (-)-[3R,4S]-Chromanol 293B

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	32.44	100 with gentle warming
	DMSO	32.44	100 with gentle warming

Preparing Stock Solutions for (-)-[3R,4S]-Chromanol 293B

The following data is based on the product molecular weight 324.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.08 mL	15.41 mL	30.83 mL
5 mM	0.62 mL	3.08 mL	6.17 mL
10 mM	0.31 mL	1.54 mL	3.08 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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References for (-)-[3R,4S]-Chromanol 293B

References are publications that support the biological activity of the product.

Seebohm A kinetic study on the stereospecific inhibition of KCNQ1 and I_Ks by the chromanol 293B. Br.J.Pharmacol. 2001 PMID: 11739240
Yang Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels. J.Pharmacol.Exp.Ther. 2000 PMID: 10945846
Lerche Molecular impact of MinK on the enantiospecific block of I_Ks by chromanols. Br.J.Pharmacol. 2001 PMID: 11139424