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Recombinant SARS-CoV-2 B.1.1.7 Spike His-tag Protein, CF

Alpha Variant (UK) Resistant to Furin & Stabilized Prefusion Conformation
(3)
Surface plasmon resonance (SPR) sensorgram of Human ACE-2 binding to UK variant B.1.1.7 Spike mutant protein

Key Product Details

Source: HEK293
Accession #: YP_009724390.1
Applications: Bioactivity

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Citations for Recombinant SARS-CoV-2 B.1.1.7 Spike His-tag Protein, CF

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FAQs

  • What is meant by "Resistant to Furin & Stabilized Prefusion Conformation?" in the description for Recombinant SARS-CoV-2 B.1.1.7 Spike His-tag Protein, CF (Catalog # 10748-CV)?

    Furin cleavage resistance is conferred by the Arg682Ser and Arg685Ser mutations. The mutations Lys986Pro and Val987Pro stabilize and promote the prefusion conformation of this Spike protein.

  • Recombinant SARS-CoV-2 B.1.1.7 Spike His-tag Protein, CF (Catalog # 10748-CV) states: Alpha Variant (UK) Resistant to Furin & Stabilized Prefusion Conformation. What does Resistant to Furin and Stabilized Prefusion mean?

    This spike protein is maintained structurally with stabilizing mutations, K986P and V987P, that promote the prefusion conformation. Additionally, two mutations, R682S and R685S, are included which eliminate a Furin protease cleavage site between the S1 and S2 subunits.

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