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Spike: Proteins and Enzymes

The Coronavirus Spike protein (S Protein) is one of four major structural proteins (S, M, E, N) present in each viral particle. Spike proteins are abundantly expressed on the surface forming its characteristic crown-like halo structure. The Spike protein is a highly glycosylated, type I transmembrane protein that plays a critical role in receptor recognition and host cell entry. There are two subunits, S1 and S2, that divide the protein roughly in half. Within the N-terminal S1 subunit is the N-terminal domain and receptor binding domain (Spike RBD protein). The Spike RBD binds to the host cell and undergoes several conformational changes and proteolysis leading to fusion of the virus particle to the host cell membrane allowing transfer of the nucleocapsid into the host cell cytoplasm. For SARS-CoV-2, the virus responsible for the COVID-19 pandemic, the Spike RBD tightly associates with human ACE-2. Recombinant SARS-CoV-2 proteins and antibodies that recognize these proteins are essential for studying the molecular mechanisms of the coronavirus life cycle.

96 results for "Spike Proteins and Enzymes" in Products

Spike: Proteins and Enzymes

The Coronavirus Spike protein (S Protein) is one of four major structural proteins (S, M, E, N) present in each viral particle. Spike proteins are abundantly expressed on the surface forming its characteristic crown-like halo structure. The Spike protein is a highly glycosylated, type I transmembrane protein that plays a critical role in receptor recognition and host cell entry. There are two subunits, S1 and S2, that divide the protein roughly in half. Within the N-terminal S1 subunit is the N-terminal domain and receptor binding domain (Spike RBD protein). The Spike RBD binds to the host cell and undergoes several conformational changes and proteolysis leading to fusion of the virus particle to the host cell membrane allowing transfer of the nucleocapsid into the host cell cytoplasm. For SARS-CoV-2, the virus responsible for the COVID-19 pandemic, the Spike RBD tightly associates with human ACE-2. Recombinant SARS-CoV-2 proteins and antibodies that recognize these proteins are essential for studying the molecular mechanisms of the coronavirus life cycle.

96 results for "Spike Proteins and Enzymes" in Products

Ectodomain, Stabilized Prefusion Conformation, Resistant to Furin Cleavage

BA

Biotinylated via Amines

BA

(1-1273 4x aa mut.)

BA

Omicron variant

BA

Omicron Variant His-tag

Catalog #: 10989-CV
BA
BA

Alpha Variant (UK) Resistant to Furin & Stabilized Prefusion Conformation

BA

B.1.351 His-tag Beta Variant (South Africa)

BA

Beta Variant (South Africa)

CHO expressed. GCN4-IZ trimerization domain. Prefusion Conformation. High ACE-2 binding

BA

L452R T478K Delta Variant (India)

BA

(GCN4-IZ) His-tag Gamma (Brazilian) Variant

BA

His-tag Biotinylated

BA

Biotinylated

BA

Omicron Variant Biotinylated His-tag

His-tag Kappa Variant (India)

Alpha Variant (UK)

BA

His-tag

BA

Delta Variant (India) His-tag

BA
BA

(GCN4-IZ) Gamma (Brazilian) Variant His-tag

BA

Omicron Variant His-tag

BA

Beta Variant (South Africa)

BA
BA

His-tag Biotinylated Delta Variant (India)

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