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Spike: Proteins and Enzymes

The Coronavirus Spike protein (S Protein) is one of four major structural proteins (S, M, E, N) present in each viral particle. Spike proteins are abundantly expressed on the surface forming its characteristic crown-like halo structure. The Spike protein is a highly glycosylated, type I transmembrane protein that plays a critical role in receptor recognition and host cell entry. There are two subunits, S1 and S2, that divide the protein roughly in half.

Within the N-terminal S1 subunit is the N-terminal domain and receptor binding domain (Spike RBD protein). The Spike RBD binds to the host cell and undergoes several conformational changes and proteolysis leading to fusion of the virus particle to the host cell membrane allowing transfer of the nucleocapsid into the host cell cytoplasm. For SARS-CoV-2, the virus responsible for the COVID-19 pandemic, the Spike RBD tightly associates with human ACE-2. Recombinant SARS-CoV-2 proteins and antibodies that recognize these proteins are essential for studying the molecular mechanisms of the coronavirus life cycle.

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114 results for "Spike Proteins and Enzymes" in Products

Spike: Proteins and Enzymes

The Coronavirus Spike protein (S Protein) is one of four major structural proteins (S, M, E, N) present in each viral particle. Spike proteins are abundantly expressed on the surface forming its characteristic crown-like halo structure. The Spike protein is a highly glycosylated, type I transmembrane protein that plays a critical role in receptor recognition and host cell entry. There are two subunits, S1 and S2, that divide the protein roughly in half.

Within the N-terminal S1 subunit is the N-terminal domain and receptor binding domain (Spike RBD protein). The Spike RBD binds to the host cell and undergoes several conformational changes and proteolysis leading to fusion of the virus particle to the host cell membrane allowing transfer of the nucleocapsid into the host cell cytoplasm. For SARS-CoV-2, the virus responsible for the COVID-19 pandemic, the Spike RBD tightly associates with human ACE-2. Recombinant SARS-CoV-2 proteins and antibodies that recognize these proteins are essential for studying the molecular mechanisms of the coronavirus life cycle.

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114 results for "Spike Proteins and Enzymes" in Products

Ectodomain, Stabilized Prefusion Conformation, Resistant to Furin Cleavage

BA

Biotinylated via Amines

Omicron variant

GCN4-IZ trimerization domain, Stabilized Prefusion Conformation, Resistant to Furin Cleavage

Delta Variant (India) His-tag

His-tag. +E484K Point Mutation

BA

Biotinylated

His-tag Kappa Variant (India)

His-tag. Iota Variant+S477N Mutation.

BA

(GCN4-IZ) His-tag Gamma (Brazilian) Variant

BA

Alpha Variant (UK) with S494P Mutation. His-tag

Alpha Variant (UK)

Omicron Variant His-tag

BA

(GCN4-IZ) Gamma (Brazilian) Variant His-tag

Alpha Variant (UK) Resistant to Furin & Stabilized Prefusion Conformation

BA, BA
BA

Delta Variant

CHO Expressed, 4 Point Mutations

BA
BA

Omicron Variant Biotinylated His-tag

BA

D614G, Q677H

BA

Alpha Variant (UK) with E484K Point Mutation. His-tag.

BA

CHO Expressed His-tag. Mutations: D614G, R682S, R685S, K986P, V987P

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