Does IL-1 beta induce NO in smooth muscle?

Name: Recombinant Rat IL-1 beta/IL-1F2 Protein
Brand: R&D Systems
SKU: 501-RL
Rating: 5 (1 reviews)

Yes it does, based on the literature.

Recombinant Rat IL-1 beta/IL-1F2 Protein

R&D Systems, Inc. a Bio-Techne Brand

Catalog # 501-RL

Citations (57)

(1)

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Setting the standard in quality research reagents

Key Product Details

Source:	E. coli
Accession #:	Q63264
Applications:	Bioactivity

View Full Technical Details for Recombinant Rat IL-1 beta/IL-1F2 Protein

Product Specifications for Recombinant Rat IL-1 beta/IL-1F2 Protein

Source	E. coli-derived rat IL-1 beta/IL-1F2 protein Val117-Ser268, with an N-terminal Met
Purity	>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin level	<0.01 EU per 1 μg of the protein by the LAL method.
N-terminal sequence Analysis	Met
Predicted Molecular Mass	17 kDa
Activity	Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. Symons, J.A. et al. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 272. The ED₅₀ for this effect is 0.300‑1.50 ng/mL.

Scientific Data Examples for Recombinant Rat IL-1 beta/IL-1F2 Protein

	Recombinant Rat IL-1 beta/IL-1F2 Protein Bioactivity Recombinant Rat IL-1 beta /IL-1F2 (Catalog # 501-RL) stimulates cell proliferation of the D10.G4.1 mouse helper T cell line. The ED₅₀ for this effect is 0.300-1.50 ng/mL.
	Recombinant Rat IL-1 beta/IL-1F2 Protein SDS-PAGE 1 μg/lane of Recombinant Rat IL-1 beta /IL-1F2 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 18 kDa.

Formulation, Preparation and Storage

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

501-RL

Carrier

Formulation	Lyophilized from a 0.2 μm filtered solution in MES, NaCl, EDTA, DTT and PEG 8000 with BSA as a carrier protein.
Reconstitution	Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

501-RL/CF

Carrier Free

Formulation	Lyophilized from a 0.2 μm filtered solution in MES, NaCl, EDTA, DTT and PEG 8000.
Reconstitution	Reconstitute at 100 μg/mL in sterile PBS.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IL-1 beta/IL-1F2

IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2), which are the products of distinct genes. IL-1 alpha and IL-1 beta are structurally related polypeptides that share approximately 26% amino acid (aa) identity in rat. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1 alpha and IL-1 beta are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1 RI binds directly to IL-1 alpha or IL-1 beta and then associates with IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. IL-1 RII has high affinity for IL-1 beta but functions as a decoy receptor and negative regulator of IL-1 beta activity. IL-1ra functions as a competitive antagonist by preventing IL-1 alpha and IL-1 beta from interacting with IL-1 RI (1 - 4). The rat IL-1 beta cDNA encodes a 268 aa precursor. A 116 aa propeptide is cleaved intracellularly by the cysteine protease IL-1 beta -converting enzyme (Caspase-1/ICE) to generate the active cytokine (5, 6). The 17 kDa mature rat IL-1 beta shares 90% aa sequence identity with cotton rat and mouse and 65% - 77% with canine, equine, feline, human, porcine, and rhesus IL-1 beta.

Item	Value
References	Allan, S.M. et al., (2005) Nat. Rev. Immunol. 5:629. Boraschi, D. and A. Tagliabue (2006) Vitam. Horm. 74:229. Kornman, K.S., (2006) Am. J. Clin. Nutr. 83:475S. Isoda, K. and F. Ohsuzu (2006) J. Atheroscler. Thromb. 13:21. Accession # M98820. Martinon, F. and J. Tschopp (2007) Cell Death Differ. 14:10.
Long Name	Interleukin 1 beta
Entrez Gene IDs	3553 (Human); 16176 (Mouse); 24494 (Rat); 397122 (Porcine); 403974 (Canine); 100034237 (Equine); 100135556 (Guinea Pig)
Alternate Names	IL-1, IL-1 beta, IL-1F2, IL-1b, IL1 beta, IL1-BETA, IL1B, IL1F2IL-1 beta, catabolin, interleukin 1, beta, interleukin-1 beta, preinterleukin 1 beta, pro-interleukin-1-beta

Citations for Recombinant Rat IL-1 beta/IL-1F2 Protein (57)

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Citations are publications that use Bio-Techne products. Selected citations for Recombinant Rat IL-1 beta/IL-1F2 Protein include:

Species: Rat
Sample Types: In Vivo
Applications: In Vivo

CMD Mota et al. (2022), Neural circuits mediating circulating interleukin-1beta-evoked fever in the absence of prostaglandin E2 production Brain, Behavior, and Immunity, 103(0):109-121.
PMID: 35429606
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

GY Min et al. (2021), Inhibition effect of Caragana sinica root extracts on Osteoarthritis through MAPKs, NF-&kappaB signaling pathway International Journal of Medical Sciences, 18(4):861-872.
PMID: 33456343
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

K Xu et al. (2021), Spironolactone Ameliorates Senescence and Calcification by Modulating Autophagy in Rat Tendon-Derived Stem Cells via the NF-kappaB/MAPK Pathway Oxidative Medicine and Cellular Longevity, 2021(0):5519587.
PMID: 34306308
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

J Yan et al. (2021), Selonsertib Alleviates the Progression of Rat Osteoarthritis: An in vitro and in vivo Study Frontiers in Pharmacology, 12(0):687033.
PMID: 34322020
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

J Bao et al. (2021), circFAM160A2 Promotes Mitochondrial Stabilization and Apoptosis Reduction in Osteoarthritis Chondrocytes by Targeting miR-505-3p and SIRT3 Oxidative Medicine and Cellular Longevity, 2021(0):5712280.
PMID: 34646424
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

B Ni et al. (2021), MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of Osteoarthritis Oxidative Medicine and Cellular Longevity, 2021(0):4139048.
PMID: 34777685
Species: Rat
Sample Types: Whole Cells
Applications: Cell Culture

MMA de Almeida et al. (2020), Phytoestrogen Agathisflavone Ameliorates Neuroinflammation-Induced by LPS and IL-1&beta and Protects Neurons in Cocultures of Glia/Neurons Biomolecules, 10(4).
PMID: 32272581
Species: Rat
Sample Types: Whole Cells
Applications: Cell Culture

SAA Moqbel et al. (2020), Rat Chondrocyte Inflammation and Osteoarthritis Are Ameliorated by Madecassoside Oxid Med Cell Longev, 2020(0):7540197.
PMID: 32089778
Species: Rat
Sample Types: Tissue Homogenates
Applications: Western Blot

Z Liu et al. (2020), Hydrogen Sulfide Protects against Paraquat-Induced Acute Liver Injury in Rats by Regulating Oxidative Stress, Mitochondrial Function, and Inflammation Oxid Med Cell Longev, 2020(0):6325378.
PMID: 32064027
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

C Lian et al. (2020), Targeting miR-18a sensitizes chondrocytes to anticytokine therapy to prevent osteoarthritis progression Cell Death Dis, 11(11):947.
PMID: 33144571
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

X Ding et al. (2020), Serum IgG-induced microglial activation enhances neuronal cytolysis via the NO/sGC/PKG pathway in children with opsoclonus-myoclonus syndrome and neuroblastoma J Neuroinflammation, 17(1):190.
PMID: 32546235
Sample Types: DNA
Applications: Bioassay

DR Ho et al. (2020), Beneficial Effects of Inflammatory Cytokine-Targeting Aptamers in an Animal Model of Chronic Prostatitis Int J Mol Sci, 21(11).
PMID: 32486412
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

SA Rajput et al. (2020), Bergenin protects pancreatic beta cells against cytokine-induced apoptosis in INS-1E cells PLoS ONE, 15(12):e0241349.
PMID: 33347462
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

J Ge et al. (2020), Calcitonin inhibits intervertebral disc degeneration by regulating protein kinase C J. Cell. Mol. Med., 0(0).
PMID: 32564456
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

CL Mai et al. (2019), Differential regulation of GSK-3? in spinal dorsal horn and in hippocampus mediated by IL-1? contributes to pain hypersensitivity and memory deficits following peripheral nerve injury Mol Pain, 0(0):1744806919826.
PMID: 30632435
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

M Carstensen et al. (2019), Sfrp5 increases glucose-stimulated insulin secretion in the rat pancreatic beta cell line INS-1E PLoS ONE, 14(3):e0213650.
PMID: 30921355
Species: Rat
Sample Types: Whole Cell
Applications: Bioassay

C Ma et al. (2019), The pro-inflammatory effect of NR4A3 in osteoarthritis J. Cell. Mol. Med., 0(0).
PMID: 31701670
Species: Rat
Sample Types: Whole Cells

WS Lian et al. (2018), MicroRNA-128a represses chondrocyte autophagy and exacerbates knee osteoarthritis by disrupting Atg12 Cell Death Dis, 9(9):919.
PMID: 30206206
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

O Stojadinov et al. (2017), Wound healing protects against chemotherapy-induced alopecia in young rats via up-regulating interleukin-1?-mediated signaling Heliyon, 3(5):e00309.
PMID: 28607955
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

AL Clark et al. (2017), Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death Sci Rep, 7(1):5611.
PMID: 28717166
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

U Guendisch et al. (2017), Pharmacological inhibition of ROR?t suppresses the Th17 pathway and alleviates arthritis in vivo PLoS ONE, 12(11):e0188391.
PMID: 29155882
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

C Guntermann et al. (2017), Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations JCI Insight, 2(5):e91127.
PMID: 28289717
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

PT Wu et al. (2017), High-molecular-weight hyaluronic acid attenuated matrix metalloproteinase-1 and -3 expression via CD44 in tendinopathy Sci Rep, 7(0):40840.
PMID: 28091588
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

R Natoli et al. (2017), Microglia-derived IL-1? promotes chemokine expression by Mï¿½ller cells and RPE in focal retinal degeneration Mol Neurodegener, 12(1):31.
PMID: 28438165
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Kotaro Nishida (2016), Expression of adiponectin receptors in human and rat intervertebral disc cells and changes in receptor expression during disc degeneration using a rat tail temporary static compression model J Orthop Surg Res, 11(1):147.
PMID: 27876065
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Kangwantas K et al. (2016), The extracellular matrix protein laminin-10 promotes blood-brain barrier repair after hypoxia and inflammation in vitro. J Neuroinflammation, 13(1):25.
PMID: 26832174
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Arous C et al. (2015), Short term exposure of beta cells to low concentrations of interleukin-1beta improves insulin secretion through focal adhesion and actin remodeling and regulation of gene expression. J Biol Chem, 290(10):6653-69.
PMID: 25586177
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Tsukahara T et al. (2015), Tumor necrosis factor alpha decreases glucagon-like peptide-2 expression by up-regulating G-protein-coupled receptor 120 in Crohn disease. Am J Pathol, 185(1):185-96.
PMID: 25447053
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

Delpech J et al. (2015), Microglial activation enhances associative taste memory through purinergic modulation of glutamatergic neurotransmission. J Neurosci, 35(7):3022-33.
PMID: 25698740
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Dahllof M et al. (2015), HDAC inhibitor-mediated beta-cell protection against cytokine-induced toxicity is STAT1 Tyr701 phosphorylation independent. J Interferon Cytokine Res, 35(1):63-70.
PMID: 25062500
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Steelman A et al. (2014), Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis. J Biol Chem, 288(33):23776-87.
PMID: 23836896
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Vistnes M et al. (2014), Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding. PLoS ONE, 9(3):e89621.
PMID: 24595230
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Lee C et al. (2014), Nitric oxide and interleukin-1beta stimulate the proteasome-independent degradation of the retinoic acid hydroxylase CYP2C22 in primary rat hepatocytes. J Pharmacol Exp Ther, 348(1):141-52.
PMID: 24144795
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Lazzaro M et al. (2014), Ceruloplasmin potentiates nitric oxide synthase activity and cytokine secretion in activated microglia. J Neuroinflammation, 11(0):164.
PMID: 25224679
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Chentouf M et al. (2014), Possible protective effect of membrane lipid rafts against interleukin-1beta-mediated anti-proliferative effect in INS-1 cells. PLoS ONE, 9(7):e102889.
PMID: 25068701
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Weaver J et al. (2013), Regulation of NOX-1 expression in beta cells: a positive feedback loop involving the Src-kinase signaling pathway. Mol Cell Endocrinol, 369(1):35-41.
PMID: 23410839
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Hull R et al. (2013), Combined ChIP-Seq and transcriptome analysis identifies AP-1/JunD as a primary regulator of oxidative stress and IL-1beta synthesis in macrophages. BMC Genomics, 14(0):92.
PMID: 23398888
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Macco R et al. (2013), Astrocytes acquire resistance to iron-dependent oxidative stress upon proinflammatory activation. J Neuroinflammation, 10(0):130.
PMID: 24160637
Species: Rat
Sample Types: Whole Cells
Applications: Cell Culture

Lim S et al. (2013), Neuronal synapse formation induced by microglia and interleukin 10. PLoS ONE, 8(11):e81218.
PMID: 24278397
Species: Human
Sample Types: Buffer
Applications: Binding Assay

Owyang AM et al. (2011), XOMA 052, a potent, high-affinity monoclonal antibody for the treatment of IL-1beta-mediated diseases. MAbs, 3(1):49-60.
PMID: 21048425
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

Koo JW et al. (2009), Interleukin-1 receptor null mutant mice show decreased anxiety-like behavior and enhanced fear memory. Neurosci. Lett., 456(1):39-43.
PMID: 19429130
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Schwarznau A et al. (2009), IL-1beta receptor blockade protects islets against pro-inflammatory cytokine induced necrosis and apoptosis. J. Cell. Physiol., 220(2):341-7.
PMID: 19334038
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

Gonzalez PV et al. (2009), Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors. Brain Behav. Immun., 23(6):817-22.
PMID: 19275930
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

Miyoshi K et al. (2008), Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury. J. Neurosci., 28(48):12775-87.
PMID: 19036970
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

Scarlett JM et al. (2008), Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation. Endocrinology, 149(10):4837-45.
PMID: 18583425
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

Koo JW et al. (2008), IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress. Proc. Natl. Acad. Sci. U.S.A., 105(2):751-6.
PMID: 18178625
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Husberg C et al. (2008), Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure. J. Mol. Cell. Cardiol., 45(2):261-9.
PMID: 18585734
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Russo TA et al. (2008), Rat pneumonia and soft-tissue infection models for the study of Acinetobacter baumannii biology. Infect. Immun., 76(8):3577-86.
PMID: 18541654
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

Engstrom L et al. (2008), Systemic immune challenge activates an intrinsically regulated local inflammatory circuit in the adrenal gland. Endocrinology, 149(4):1436-50.
PMID: 18174279
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Paintlia AS et al. (2008), Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis. Mol. Pharmacol., 73(5):1381-93.
PMID: 18239032
Roche M et al. (2006), In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids. J. Neuroimmunol., 181(1):57-67.
PMID: 17011047
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Barkho BZ et al. (2006), Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. Stem Cells Dev., 15(3):407-21.
PMID: 16846377
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Fernandes A et al. (2006), Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin. J. Neurochem., 96(6):1667-79.
PMID: 16476078
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

Sergejeva S et al. (2004), A synthetic VIP peptide analogue inhibits neutrophil recruitment in rat airways in vivo. Regul. Pept., 117(2):149-54.
PMID: 14700751
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

Frewert S et al. (2004), Intratumoral infusion of interleukin-1beta and interferon-gamma induces tumor invasion with macrophages and lymphocytes in a rat glioma model. Neurosci. Lett., 364(3):145-8.
PMID: 15196664
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

Nedrebo T et al. (2004), Differential cytokine response in interstitial fluid in skin and serum during experimental inflammation in rats. J. Physiol. (Lond.), 556(0):193-202.
PMID: 14724215
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

Blais V et al. (2002), In altering the release of glucocorticoids, ketorolac exacerbates the effects of systemic immune stimuli on expression of proinflammatory genes in the brain. Endocrinology, 143(12):4820-7.
PMID: 12446609

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Customer Reviews for Recombinant Rat IL-1 beta/IL-1F2 Protein (1)

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Recombinant Rat IL-1 beta/IL-1F2 Protein

Name: Anonymous

Application: Immunoassay Standard

Verified Customer | Posted 11/07/2017

This recombinant protein worked very well as a calibrator in an ELISA built to measure Rat serum IL-1b.

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FAQs for Recombinant Rat IL-1 beta/IL-1F2 Protein

Does IL-1 beta induce NO in smooth muscle?

Yes it does, based on the literature.

Recombinant Rat IL-1 beta/IL-1F2 Protein

R&D Systems, Inc. a Bio-Techne Brand

Key Product Details

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Product Specifications for Recombinant Rat IL-1 beta/IL-1F2 Protein

Scientific Data Examples for Recombinant Rat IL-1 beta/IL-1F2 Protein

Formulation, Preparation and Storage

Carrier Free

501-RL

Carrier

501-RL/CF

Carrier Free

Reconstitution Calculator

Background: IL-1 beta/IL-1F2

Citations for Recombinant Rat IL-1 beta/IL-1F2 Protein (57)

Customer Reviews for Recombinant Rat IL-1 beta/IL-1F2 Protein (1)

Customer Images

Recombinant Rat IL-1 beta/IL-1F2 Protein

FAQs for Recombinant Rat IL-1 beta/IL-1F2 Protein

Product Documents for Recombinant Rat IL-1 beta/IL-1F2 Protein

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