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Recombinant Mouse Cathepsin X/Z/P Protein, CF

Catalog # 1033-CY | R&D Systems, Inc. a Bio-Techne Brand
Catalog #
Size / Price

Key Product Details



Accession #

Structure / Form

Pro form




Enzyme Activity

Product Specifications


Mouse myeloma cell line, NS0-derived mouse Cathepsin X/Z/P protein
Ala23-Val306 & Leu27-Val306, both with a C-terminal 10-His tag


>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Endotoxin Level

<1.0 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis

Ala23 & Leu27

Predicted Molecular Mass

33 kDa


40 kDa, reducing conditions


Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPPGFSAFK(Dnp)-OH (Catalog # ES005).
The specific activity is >1,200 pmol/min/µg, as measured under the described conditions.

Formulation, Preparation and Storage

Formulation Supplied as a 0.2 μm filtered solution in Sodium Acetate and NaCl.
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 6 months from date of receipt, -20 to -70 °C as supplied.
  • 3 months, -20 to -70 °C under sterile conditions after opening.

Background: Cathepsin X/Z/P

Cathepsin X (also known as Cathepsin Z and P) is a relatively new cysteine protease of the papain family (1‑5). Compared to other members of the papain family, Cathepsin X has a short proregion and unique insertions. The cysteine residue in the proregion forms a covalent and reversible bond with the active site cysteine residue (6). Acting as a carboxypeptidase, Cathepsin X displays a unique specificity (7‑10). It is ubiquitously expressed in human tissues and conserved in other species such as mouse, nematode and echiuran. The nematode enzyme is apparently involved in molting of third stage larvae (11).


  1. Deussing, et al. (2000) Biochim. Biophys. Acta 1491:93.
  2. Santamaria, et al. (1998) J. Biol. Chem. 273:16816.
  3. Nagler and Menard (1998) FEBS Lett. 434:135.
  4. Pungercar and Ivanovski (2000) Pflugers Arch. 439:R116.
  5. Pungercar, et al. (2000) Pflugers Arch. 439:R119.
  6. Sivaraman, et al. (2000) J. Mol. Biol. 295:935.
  7. Menard, et al. (2001) Biol. Chem. 382:839.
  8. Therrien, et al. (2001) Biochemistry 40:2702.
  9. Klemencic, et al. (2000) Eur. J. Biochem. 267:5404.
  10. Guncar, et al. (2000) Structure Fold Des. 8:305.
  11. Lustigman, et al. (1996) J. Biol. Chem. 271:30181.

Alternate Names

Cathepsin P, Cathepsin Z, CTSZ

Entrez Gene IDs

1522 (Human); 64138 (Mouse)

Gene Symbol



Product Documents for Recombinant Mouse Cathepsin X/Z/P Protein, CF

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Recombinant Mouse Cathepsin X/Z/P Protein, CF

For research use only

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