Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Name: Human IL-1 beta/IL-1F2 Quantikine ELISA Kit
Brand: R&D Systems
SKU: DLB50
Rating: 5 (12 reviews)

R&D Systems, Inc. a Bio-Techne Brand

Catalog # DLB50

Citations (287)

(12)

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Setting the standard in quality research reagents

Key Product Details

Assay Length:	3.5 hours or 4.5 hours
Sample Type & Volume Required Per Well:	Cell Culture Supernates (200 uL), Serum (200 uL), EDTA Plasma (200 uL), Heparin Plasma (200 uL), Citrate Plasma (200 uL)
Sample Types:	Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma
Sensitivity:	1 pg/mL
Assay Range:	3.9 - 250 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma)
Human IL-1 beta/IL-1F2 Quantikine ELISA Kit Summary:	The Quantikine Human IL-1 beta Immunoassay is a 3.5 or 4.5 hour solid phase ELISA designed to measure IL-1 beta in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human IL-1 beta and antibodies raised against the recombinant factor. It has been shown to quantitate recombinant human IL-1 beta accurately. Results obtained using natural IL-1 beta showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural IL-1 beta. Reports indicate that this and other ELISA kits calibrated using mature IL-1 beta as a standard will detect, but considerably underestimate, the unprocessed IL-1 beta precursor present in samples. In biological samples other than cell lysates, the precursor form of IL-1 beta is usually not the predominant form of IL-1 beta present and, additionally, is not biologically active. Therefore, results obtained using this kit should provide a useful measure of the levels of active IL-1 beta present in biological fluids.

View Full Technical Details for Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Product Specifications for Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Assay Type	Solid Phase Sandwich ELISA
Format	96-well strip plate
Measurement	Quantitative ELISA
Detection Method	Colorimetric - 450nm (TMB)
Conjugate	HRP
Reactivity	Human
Specificity	Natural and recombinant human IL-1 beta
Cross-reactivity	< 0.5% cross-reactivity observed with available related molecules. < 50% cross-species reactivity observed with species tested.
Interference	Interference observed with 1 or more available related molecules.

Precision

Intra-Assay Precision (Precision within an assay) Four samples of known concentration were tested on one plate to assess intra-assay precision

Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision

Cell Culture Supernates

	Intra-Assay Precision				Inter-Assay Precision
Sample	1	2	3	4	1	2	3
n	20	20	20	20	20	20	20
Mean (pg/mL)	12.6	30.4	69.2	192	30.8	120	194
Standard Deviation	0.3	1	1.6	6.5	2.2	4.1	7.9
CV%	2.4	3.3	2.3	3.4	7.1	3.4	4.1

Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma

	Intra-Assay Precision				Inter-Assay Precision
Sample	1	2	3	4	1	2	3
n	20	20	20	20	20	20	20
Mean (pg/mL)	18.9	30.2	122	181	29.8	118	193
Standard Deviation	1.6	1	5.4	5	2.5	5	8
CV%	8.5	3.3	4.4	2.8	8.4	4.2	4.1

Recovery

The recovery of IL-1 beta spiked to different levels throughout the range of the assay in various matrices was evaluated.

Sample Type	Average % Recovery	Range %
Cell Culture Media (n=4)	97	80-111
Citrate Plasma (n=10)	93	83-110
EDTA Plasma (n=10)	86	81-100
Heparin Plasma (n=10)	82	76-100
Serum (n=10)	95	87-110

Linearity

To assess linearity of the assay, the following biological samples containing, or spiked with, high concentrations of IL-1 beta were diluted with the appropriate Calibrator Diluent and then assayed.

Scientific Data Examples for Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

	Human IL1B ELISA Cell Culture Supernate Standard Curve
	Human IL1B ELISA Serum/Plasma Standard Curve

Preparation and Storage

Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: IL-1 beta/IL-1F2

The Interleukin 1 (IL-1) family of proteins consists of the classic members IL-1 alpha, IL-1 beta, and IL-1ra, plus IL-18, IL-33 and IL-1F5-F10. IL-1 alpha and IL-1 beta bind to the same cell surface receptors and share biological functions. IL-1 is not produced by unstimulated cells of healthy individuals with the exception of skin keratinocytes, some epithelial cells, and certain cells of the central nervous system. However, in response to inflammatory agents, infections, or microbial endotoxins, a dramatic increase in the production of IL-1 by macrophages and various other cell types is observed. IL-1 beta plays a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. Inappropriate or prolonged production of IL-1 has been implicated in a variety of pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases.

IL-1 alpha and IL-1 beta are structurally related polypeptides that show approximately 25% homology at the amino acid level. Both are synthesized as 31 kDa precursors that are subsequently cleaved into mature proteins of approximately 17.5 kDa. Cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. Neither IL-1 alpha nor IL-1 beta contains a typical hydrophobic signal peptide, but evidence suggests that these factors can be secreted by non-classical pathways. A portion of unprocessed IL-1 alpha can be presented on the cell membrane and may retain biological activity. The precursor form of IL-1 beta, unlike the IL-1 alpha precursor, shows little or no biological activity in comparison to the processed form. Both unprocessed and mature forms of IL-1 beta are exported from the cell.

IL-1 alpha and IL-1 beta exert their effects through immunoglobulin superfamily receptors that additionally bind IL-1ra. The 80 kDa transmembrane type I receptor (IL-1 RI) is expressed on T cells, fibroblasts, keratinocytes, endothelial cells, synovial lining cells, chondrocytes, and hepatocytes. The 68 kDa transmembrane type II receptor (IL-1 RII) is expressed on B cells, neutrophils, and bone marrow cells. The two IL-1 receptor types show approximately 28% homology in their extracellular domains but differ significantly in that the type II receptor has a cytoplasmic domain of only 29 amino acids (aa), whereas the type I receptor has a 213 aa cytoplasmic domain. IL-1 RII does not appear to signal in response to IL-1 and may function as a decoy receptor that attenuates IL-1 function. The IL-1 receptor accessory protein (IL-1 RAcP) associates with IL-1 RI and is required for IL-1 RI signal transduction. IL-1ra is a secreted molecule that functions as a competitive inhibitor of IL-1. Soluble forms of both IL-1 RI and IL-1 RII have been detected in human plasma, synovial fluids, and the conditioned media of several human cell lines. In addition, IL-1 binding proteins that resemble soluble IL-1 RII are encoded by vaccinia and cowpox viruses.

Item	Value
Long Name	Interleukin 1 beta
Entrez Gene IDs	3553 (Human); 16176 (Mouse); 24494 (Rat); 397122 (Porcine); 403974 (Canine); 100034237 (Equine); 100135556 (Guinea Pig)
Alternate Names	IL-1, IL-1 beta, IL-1F2, IL-1b, IL1 beta, IL1-BETA, IL1B, IL1F2IL-1 beta, catabolin, interleukin 1, beta, interleukin-1 beta, preinterleukin 1 beta, pro-interleukin-1-beta

Citations for Human IL-1 beta/IL-1F2 Quantikine ELISA Kit (287)

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Citations are publications that use Bio-Techne products. Selected citations for Human IL-1 beta/IL-1F2 Quantikine ELISA Kit include:

Species: Human
Sample Types: Cell Culture Supernates

VSMC Correa et al. (2023-01-01), The NLRP3 inflammasome - Interleukin 1beta axis in uveal melanoma FEBS Open Bio, 0(0).
PMID: 36707938
Species: Human
Sample Types: Vitreous Humor

T Tsai et al. (2023-01-01), Increased Angiopoietin-1 and -2 levels in human vitreous are associated with proliferative diabetic retinopathy PLoS ONE, 18(1):e0280488.
PMID: 36662891
Species: Human
Sample Types: Cell Culture Supernates

S Pathak et al. (2022-01-01), NaCl exposure results in increased expression and processing of IL-1beta in Meniere's disease patients Scientific Reports, 12(1):4957.
PMID: 35322136
Species: Human
Sample Types: Cell Culture Supernates

AR Griswold et al. (2022-01-01), The NLRP1 Inflammasome Induces Pyroptosis in Human Corneal Epithelial Cells Investigative Ophthalmology Visual Science, 2022;63(3):2.
PMID: 35238869
Species: Human
Sample Types: Cell Culture Supernates

SH Lee et al. (2022-01-01), Povidone iodine suppresses LPS-induced inflammation by inhibiting TLR4/MyD88 formation in airway epithelial cells Scientific Reports, 12(1):3681.
PMID: 35256715
Species: Human
Sample Types: Cell Culture Supernates

A Kowalczuk et al. (2022-01-01), Calystegines Improve the Metabolic Activity of Human Adipose Derived Stromal Stem Cells (ASCs) under Hyperglycaemic Condition through the Reduction of Oxidative/ER Stress, Inflammation, and the Promotion of the AKT/PI3K/mTOR Pathway Biomolecules, 12(3).
PMID: 35327652
Species: Human
Sample Types: Cell Culture Supernates

N Lin et al. (2022-01-01), KIF4A promotes tumor progression of bladder cancer via CXCL5 dependent myeloid-derived suppressor cells recruitment Scientific Reports, 12(1):6015.
PMID: 35399116
Species: Mouse
Sample Types: Serum

L Liang et al. (2022-01-01), Liensinine alleviates high fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) through suppressing oxidative stress and inflammation via regulating TAK1/AMPK signaling International immunopharmacology, 104(0):108306.
PMID: 34999396
Species: Human
Sample Types: Cell Culture Supernates

A Jin et al. (2022-01-01), Circ_0050908 up-regulates TRAF3 by sponging miR-324-5p to aggravate myocardial ischemia-reperfusion injury International immunopharmacology, 108(0):108740.
PMID: 35413678
Species: Human
Sample Types: Cell Culture Supernates

YJ Park et al. (2022-01-01), D-dimer and CoV-2 spike-immune complexes contribute to the production of PGE2 and proinflammatory cytokines in monocytes PloS Pathogens, 18(4):e1010468.
PMID: 35385545
Species: Rat

L Suo et al. (2022-01-01), Dexmedetomidine attenuates oxygen-glucose deprivation/ reperfusion-induced inflammation through the miR-17-5p/ TLR4/ NF-kappaB axis BMC anesthesiology, 22(1):126.
PMID: 35488217
Species: Human
Sample Types: Cell Culture Supernates

JH Shin et al. (2022-01-01), Adipokine human Resistin promotes obesity-associated inflammatory intervertebral disc degeneration via pro-inflammatory cytokine cascade activation Scientific Reports, 12(1):8936.
PMID: 35624126
Species: Human
Sample Types: Cell Culture Supernates

SV Suryavansh et al. (2022-01-01), Cannabinoids Alleviate the LPS-Induced Cytokine Storm via Attenuating NLRP3 Inflammasome Signaling and TYK2-Mediated STAT3 Signaling Pathways In Vitro Cells, 11(9).
PMID: 35563697
Species: Human
Sample Types: Plasma

F Piancone et al. (2022-01-01), Modulation of Neuroendocrine and Immunological Biomarkers Following Rehabilitation in Sarcopenic Patients Cells, 11(16).
PMID: 36010554
Species: Human
Sample Types: Cell Culture Supernates

AY Huang et al. (2022-01-01), IL-6 is involved in thoracic ossification of the ligamentum flavum PLoS ONE, 17(7):e0272357.
PMID: 35905126
Species: Human
Sample Types: Cell Culture Supernates

AA Poirier et al. (2022-01-01), Differential contribution of estrogen receptors to the intestinal therapeutic effects of 17beta-estradiol in a murine model of Parkinson's disease Brain research bulletin, 187(0):85-97.
PMID: 35781029
Species: Human
Sample Types: Cell Culture Supernates

Y Wu et al. (2022-01-01), Lipopolysaccharide Inhibits Autophagy and Promotes Inflammatory Responses via p38 MAPK-Induced Proteasomal Degradation of Atg13 in Hepatic Stellate Cells Mediators of Inflammation, 2022(0):9603989.
PMID: 36148140
Species: Human
Sample Types: Cell Culture Supernates

M O'Farrell et al. (2022-01-01), FASN inhibition targets multiple drivers of NASH by reducing steatosis, inflammation and fibrosis in preclinical models Scientific Reports, 12(1):15661.
PMID: 36123383
Species: Human
Sample Types: Cell Culture Supernates

F La Rosa et al. (2022-01-01), Modulation of MAPK- and PI3/AKT-Dependent Autophagy Signaling by Stavudine (D4T) in PBMC of Alzheimer's Disease Patients Cells, 11(14).
PMID: 35883623
Species: Human

C Su et al. (2022-01-01), Platyconic acid A?induced PPM1A upregulation inhibits the proliferation, inflammation and extracellular matrix deposition of TGF?beta1?induced lung fibroblasts Molecular Medicine Reports, 26(5).
PMID: 36069235
Species: Human
Sample Types: Cell Culture Supernates

Y Zhang et al. (2022-01-01), IL-1beta-Triggered Long Non-coding RNA CHRF Induces Non-Small Cell Lung Cancer by Modulating the microRNA-489/Myd88 Axis Journal of Cancer, 13(8):2620-2630.
PMID: 35711847
Species: Human
Sample Types: Serum

MPL Galantini et al. (2022-01-01), The sweet fuel of inflammation: New perspectives on the complex web that interconnects diabetes Experimental gerontology, 167(0):111905.
PMID: 35918042
Species: Human
Sample Types: Serum

N Ma et al. (2022-01-01), Effects of resveratrol therapy on glucose metabolism, insulin resistance, inflammation, and renal function in the elderly patients with type 2 diabetes mellitus: A randomized controlled clinical trial protocol Medicine, 101(32):e30049.
PMID: 35960095
Species: Primate - Chlorocebus aethiops (African Green Monkey)
Sample Types: Plasma

AD Ruggiero et al. (2022-01-01), Macrophage Phenotypes and Gene Expression Patterns Are Unique in Naturally Occurring Metabolically Healthy Obesity International Journal of Molecular Sciences, 23(20).
PMID: 36293536
Species: Human
Sample Types: Cell Culture Supernates

MC Chiang et al. (2022-01-01), Resveratrol Mitigates Oxygen and Glucose Deprivation-Induced Inflammation, NLRP3 Inflammasome, and Oxidative Stress in 3D Neuronal Culture International Journal of Molecular Sciences, 23(19).
PMID: 36232980
Species: Human
Sample Types: Cell Culture Supernates

A Salzano et al. (2022-01-01), Breed and Feeding System Impact the Bioactive Anti-Inflammatory Properties of Bovine Milk International Journal of Molecular Sciences, 23(19).
PMID: 36232386
Species: Human
Sample Types: Serum

Y Song et al. (2022-01-01), Effect of Propofol versus Sevoflurane Anesthesia on Acute Kidney Injury after Lung Transplantation Surgery: A Prospective Randomized Controlled Trial Journal of Clinical Medicine, 11(22).
PMID: 36431341
Species: Human
Sample Types: Cell Culture Supernates

J Milara et al. (2022-01-01), N-acetylcysteine Reduces Inflammasome Activation Induced by SARS-CoV-2 Proteins In Vitro International Journal of Molecular Sciences, 23(23).
PMID: 36498845
Species: Human
Sample Types: Cell Culture Supernates

J Park et al. (2022-01-01), Effects of Apamin on MPP+-Induced Calcium Overload and Neurotoxicity by Targeting CaMKII/ERK/p65/STAT3 Signaling Pathways in Dopaminergic Neuronal Cells International Journal of Molecular Sciences, 23(23).
PMID: 36499581
Species: Human
Sample Types: Cell Culture Supernates

Y Zhu et al. (2022-01-01), FAAH served a key membrane-anchoring and stabilizing role for NLRP3 protein independently of the endocannabinoid system Cell Death and Differentiation, 0(0).
PMID: 36104448
Species: Human
Sample Types: Cell Culture Supernates

A Nakamura et al. (2022-01-01), Bovine lactoferrin suppresses inflammatory cytokine expression in endometrial stromal cells in chronic endometritis Journal of reproductive immunology, 154(0):103761.
PMID: 36403531
Species: Human
Sample Types: Serum

CV Gonçalves et al. (2022-01-01), Inflammaging and body composition: New insights in diabetic and hypertensive elderly men Experimental gerontology, 170(0):112005.
PMID: 36341786
Species: Human
Sample Types: Cell Culture Supernates

P Hennig et al. (2022-01-01), High p62 expression suppresses the NLRP1 inflammasome and increases stress resistance in cutaneous SCC cells Cell Death Disease, 2022;13(12):1077.
PMID: 36581625
Species: Human
Sample Types: Cell Culture Supernates

LM Branco et al. (2022-01-01), Lysosomal cathepsins act in concert with Gasdermin-D during NAIP/NLRC4-dependent IL-1beta secretion Cell Death Disease, 2022;13(12):1029.
PMID: 36481780
Species: Human
Sample Types: Plasma

E Kiss et al. (2022-01-01), The Effect of Dietary Methyl-Donor Intake and Other Lifestyle Factors on Cancer Patients in Hungary Cancers, 14(18).
PMID: 36139592
Species: Rat
Sample Types: Tissue Homogenates

J Sun et al. (2021-01-01), Down-regulation of SNHG16 alleviates the acute lung injury in sepsis rats through miR-128-3p/HMGB3 axis BMC pulmonary medicine, 21(1):191.
PMID: 34092219
Species: Human
Sample Types: Serum

CS Oh et al. (2021-01-01), Impact of Anesthetic Agents on Endothelial Glycocalyx Injury during Total Knee Arthroplasty: Desflurane- vs. Propofol-Based Anesthesia-A Prospective Randomized Controlled Trial BioMed Research International, 2021(0):8880267.
PMID: 33564684
Species: Human
Sample Types: Cell Culture Supernates

ML Matias et al. (2021-01-01), Progesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 inflammasomes and TLR4-MyD88-NF-&kappaB pathway in monocytes from pregnant women with preeclampsia Journal of reproductive immunology, 144(0):103286.
PMID: 33578174
Species: Human
Sample Types: Plasma

DPS Lopes et al. (2021-01-01), Regular physical activity reduces the proinflammatory response in older women with diabetes and hypertension in the postmenopausal phase Experimental gerontology, 152(0):111449.
PMID: 34126225
Species: Human
Sample Types: Serum

A Tavakoli et al. (2021-01-01), Circulating inflammatory markers may mediate the relationship between low carbohydrate diet and circadian rhythm in overweight and obese women Oncogene, 21(1):87.
PMID: 33648476
Species: Rat
Sample Types: Cell Culture Supernates

D Gan et al. (2021-01-01), Repurposing of Pirfenidone (Anti-Pulmonary Fibrosis Drug) for Treatment of Rheumatoid Arthritis Frontiers in Pharmacology, 12(0):631891.
PMID: 33746759
Species: Human
Sample Types: Cell Culture Supernates

NE Kim et al. (2021-01-01), SARS-CoV-2 Nonstructural Proteins 1 and 13 Suppress Caspase-1 and the NLRP3 Inflammasome Activation Microorganisms, 9(3).
PMID: 33652815
Species: Human
Sample Types: Cell Culture Supernates

C Zhang et al. (2021-01-01), Porphyromonas gingivalis lipopolysaccharide promotes T-hel per17 cell differentiation by upregulating Delta-like ligand 4 expression on CD14+ monocytes PeerJ, 9(0):e11094.
PMID: 33981487
Species: Human
Sample Types: Serum

L Avila et al. (2021-01-01), Cognitive functional therapy (CFT) compared with core training exercise (CTE) in patients with failed back surgery syndrome (FBSS): A study protocol for a randomized controlled trial Journal of bodywork and movement therapies, 26(0):428-434.
PMID: 33992278
Species: Human
Sample Types: Cell Culture Supernates

L You et al. (2021-01-01), Salidroside protects endothelial cells against LPS-induced inflammatory injury by inhibiting NLRP3 and enhancing autophagy BMC complementary medicine and therapies, 21(1):146.
PMID: 34011327
Species: Human
Sample Types: Serum

GA Lavranou et al. (2021-01-01), Can Coagulation System Disorders and Cytokine and Inflammatory Marker Levels Predict the Temporary Clinical Deterioration or Improvement of Septic Patients on ICU Admission? Journal of Clinical Medicine, 10(8).
PMID: 33917002
Species: Human
Sample Types: Gingival Crevicular Fluid

P Aleksandro et al. (2021-01-01), Analysis of IL-1&beta, CXCL8, and TNF-&alpha levels in the crevicular fluid of patients with periodontitis or healthy implants BMC Oral Health, 21(1):120.
PMID: 33726736
Species: Human
Sample Types: Serum

ML Vazquez-Vi et al. (2021-01-01), Functional disability is related to serum chemerin levels in rheumatoid arthritis Scientific Reports, 11(1):8360.
PMID: 33863926
Species: Human
Sample Types: Plasma

L Scola et al. (2021-01-01), Polymorphisms of Pro-Inflammatory IL-6 and IL-1&beta Cytokines in Ascending Aortic Aneurysms as Genetic Modifiers and Predictive and Prognostic Biomarkers Biomolecules, 11(7).
PMID: 34202072
Species: Human
Sample Types: Cell Culture Supernates

NG Díaz-Marot et al. (2021-01-01), The Blockade of Tumoral IL1&beta-Mediated Signaling in Normal Colonic Fibroblasts Sensitizes Tumor Cells to Chemotherapy and Prevents Inflammatory CAF Activation International Journal of Molecular Sciences, 22(9).
PMID: 34066976
Species: Human
Sample Types: Serum

W Zhu et al. (2021-01-01), Serum levels of SIRT3 and other inflammatory factors are associated with clinical outcomes and prognosis in severe community-acquired pneumonia in adults: A prospective study Medicine, 100(32):e26721.
PMID: 34397875
Species: Human
Sample Types: Cell Culture Supernates

Y Hou et al. (2021-01-01), CD36 promotes NLRP3 inflammasome activation via the mtROS pathway in renal tubular epithelial cells of diabetic kidneys Cell Death Disease, 2021;12(6):523.
PMID: 34021126
Species: Human
Sample Types: Serum

J Dai et al. (2021-01-01), IL-1&beta Impaired Diabetic Wound Healing by Regulating MMP-2 and MMP-9 through the p38 Pathway Mediators of Inflammation, 2021(0):6645766.
PMID: 34054346
Species: Human
Sample Types: Cell Culture Supernates

C Zhang et al. (2021-01-01), Circ_0004104 knockdown alleviates oxidized low-density lipoprotein-induced dysfunction in vascular endothelial cells through targeting miR-328-3p/TRIM14 axis in atherosclerosis BMC cardiovascular disorders, 21(1):207.
PMID: 33892646
Species: Human
Sample Types: Cell Culture Supernates

X Bao et al. (2021-01-01), HIF-1alpha-Mediated miR-623 Regulates Apoptosis and Inflammatory Responses of Nucleus Pulposus Induced by Oxidative Stress via Targeting TXNIP Oxidative Medicine and Cellular Longevity, 2021(0):6389568.
PMID: 34394829
Species: Human
Sample Types: Cell Culture Supernates

Y Koga et al. (2021-01-01), DNA-Aptamer Raised against Receptor for Advanced Glycation End Products Improves Survival Rate in Septic Mice Oxidative Medicine and Cellular Longevity, 2021(0):9932311.
PMID: 34413930
Species: Human
Sample Types: Cell Culture Supernates

L Zheng et al. (2021-01-01), ELK4 promotes the development of gastric cancer by inducing M2 polarization of macrophages through regulation of the KDM5A-PJA2-KSR1 axis Journal of Translational Medicine, 19(1):342.
PMID: 34372882
Species: Human
Sample Types: Cell Culture Supernates

Y Cheng et al. (2021-01-01), The anti-tumor effects of cetuximab in combination with VTX-2337 are T cell dependent Scientific Reports, 11(1):1535.
PMID: 33452311
Species: Human
Sample Types: Cell Culture Supernates

S Groeger et al. (2021-01-01), Generation and functional characterization of recombinant Porphyromonas gingivalis W83 FimA Journal of biotechnology, 340(0):22-29.
PMID: 34478774
Species: Human
Sample Types: Cell Culture Supernates

B Han et al. (2021-01-01), High glucose?induced upregulation of CD36 promotes inflammation stress via NF?kappaB in H9c2 cells Molecular Medicine Reports, 24(5).
PMID: 34490487
Species: Human
Sample Types: Cell Culture Supernates

YZ Akkaya-Ulu et al. (2021-01-01), Familial Mediterranean fever-related miR-197-3p targets IL1R1 gene and modulates inflammation in monocytes and synovial fibroblasts Scientific Reports, 11(1):685.
PMID: 33436947
Species: Mouse
Sample Types: Plasma

Y Ni et al. (2021-01-01), Interruption of neutrophil extracellular traps formation dictates host defense and tubular HOXA5 stability to augment efficacy of anti-Fn14 therapy against septic AKI Theranostics, 11(19):9431-9451.
PMID: 34646379
Species: Human
Sample Types: Cell Culture Supernates

C Iacobini et al. (2021-01-01), Normalizing HIF-1alpha Signaling Improves Cellular Glucose Metabolism and Blocks the Pathological Pathways of Hyperglycemic Damage Biomedicines, 9(9).
PMID: 34572324
Species: Human
Sample Types: Plasma

IS Ribeiro et al. (2021-01-01), Regular physical activity reduces the effects of inflammaging in diabetic and hypertensive men Experimental gerontology, 155(0):111558.
PMID: 34547405
Species: Human
Sample Types: Cell Culture Supernates

M Koizumi et al. (2021-01-01), Apoptosis-associated speck-like protein containing a CARD regulates the growth of pancreatic ductal adenocarcinoma Scientific Reports, 11(1):22351.
PMID: 34785680
Species: Human
Sample Types: Serum

SE Lee et al. (2021-01-01), Intravenous allogeneic umbilical cord blood-derived mesenchymal stem cell therapy in recessive dystrophic epidermolysis bullosa patients JCI Insight, 6(2).
PMID: 33491668
Species: Human
Sample Types: Plasma

Y Han et al. (2021-01-01), LncRNA NEAT1 is upregulated in recurrent aphthous stomatitis (RAS) and has predictive values BMC Oral Health, 21(1):673.
PMID: 34972503
Species: Human
Sample Types: Cell Culture Supernates

T Nakajo et al. (2021-01-01), 1,25-Dihydroxyvitamin D3 attenuates IL-1beta secretion by suppressing NLRP1 inflammasome activation by upregulating the NRF2-HO-1 pathway in epidermal keratinocytes Redox Biology, 48(0):102203.
PMID: 34872043
Species: Human
Sample Types: Saliva

A Zalewska et al. (2021-01-01), Salivary gland dysfunction and salivary redox imbalance in patients with Alzheimer's disease Scientific Reports, 11(1):23904.
PMID: 34903846
Species: Human
Sample Types: Cell Culture Supernates

SO Mousavi et al. (2021-01-01), Immunological response of fallopian tube epithelial cells to spermatozoa through modulating cytokines and chemokines Journal of reproductive immunology, 146(0):103327.
PMID: 34052728
Species: Human
Sample Types: Cell Culture Supernates

F Ulgheri et al. (2021-01-01), Design, synthesis and biological evaluation of 1,5-disubstituted alpha-amino tetrazole derivatives as non-covalent inflammasome-caspase-1 complex inhibitors with potential application against immune and inflammatory disorders European Journal of Medicinal Chemistry, 0(0):114002.
PMID: 34823899
Species: Human
Sample Types: Cell Culture Supernates

IV Kravchenko et al. (2020-01-01), Glycated albumin stimulates expression of inflammatory cytokines in muscle cells Cytokine, 128(0):154991.
PMID: 32000013
Species: Human
Sample Types: Serum

N Lalaoui et al. (2020-01-01), Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease Nature, 577(7788):103-108.
PMID: 31827281
Species: Human
Sample Types: Cell Culture Supernates

YY Liu et al. (2020-01-01), Activity of fibroblast-like synoviocytes in rheumatoid arthritis was impaired by dickkopf-1 targeting siRNA Chin. Med. J., 0(6):679-686.
PMID: 32068606
Species: Human
Sample Types: Cell Culture Supernates

W Li et al. (2020-01-01), Dysfunctional Nurr1 promotes high glucose-induced Mï¿½ller cell activation by up-regulating the NF-?B/NLRP3 inflammasome axis Neuropeptides, 0(0):102057.
PMID: 32461025
Species: Human
Sample Types: Plasma

M Herrera et al. (2020-01-01), Gaps in Study Design for Immune Parameter Research for Latent Tuberculosis Infection: A Systematic Review J Immunol Res, 2020(0):8074183.
PMID: 32377537
Species: Human
Sample Types: Cell Culture Supernates

T Wang et al. (2020-01-01), LINC01116 promotes tumor proliferation and neutrophil recruitment via DDX5-mediated regulation of IL-1&beta in glioma cell Cell Death Dis, 11(5):302.
PMID: 32358484
Species: Human
Sample Types: Serum

MM Watany et al. (2020-01-01), Interleukin-31 interaction with inflammasome: A promising diagnostic and prognostic panel for early sepsis identification in critically ill patients Cytokine, 131(0):155102.
PMID: 32305780
Species: Human
Sample Types: Cell Culture Supernants

D Su et al. (2020-01-01), Tumor-neuroglia interaction promotes pancreatic cancer metastasis Theranostics, 10(11):5029-5047.
PMID: 32308766
Species: Human
Sample Types: Cell Culture Supernates

Y Meng et al. (2020-01-01), Knockdown of exosome?mediated lnc?PVT1 alleviates lipopolysaccharide?induced osteoarthritis progression by mediating the HMGB1/TLR4/NF?&kappaB pathway via miR?93?5p Molecular Medicine Reports, 22(6):5313-5325.
PMID: 33174011
Species: Human
Sample Types: Cell Culture Supernates

S Wang et al. (2020-01-01), Reduced intracellular antioxidant capacity in platelets contributes to primary immune thrombocytopenia via ROS-NLRP3-caspase-1 pathway Thrombosis Research, 199(0):1-9.
PMID: 33383234
Species: Human
Sample Types: Serum

L Ganança et al. (2020-01-01), Relationships between inflammatory markers and suicide risk status in major depression Journal of psychiatric research, 134(0):192-199.
PMID: 33388702
Species: Human
Sample Types: Serum

L Guo et al. (2020-01-01), MicroRNA-4485 ameliorates severe influenza pneumonia via inhibition of the STAT3/PI3K/AKT signaling pathway Oncology Letters, 20(5):215.
PMID: 32963621
Species: Human
Sample Types: Cell Culture Supernates

X Wang et al. (2020-01-01), Flurbiprofen suppresses the inflammation, proliferation, invasion and migration of colorectal cancer cells via COX2 Oncology Letters, 20(5):132.
PMID: 32934701
Species: Human
Sample Types: Cell Culture Supernates

D Al-Awad et al. (2020-01-01), The Role of Soluble Uric Acid in Modulating Autophagy Flux and Inflammasome Activation during Bacterial Infection in Macrophages Biomedicines, 8(12).
PMID: 33322651
Species: Human
Sample Types: Cell Culture Supernates

SA Alkandari et al. (2020-01-01), Proteomics of extracellular vesicles produced by Granulicatella adiacens, which causes infective endocarditis PLoS ONE, 15(11):e0227657.
PMID: 33216751
Species: Human
Sample Types: Cell Culture Supernates

L Peng et al. (2020-01-01), Expression of trophoblast derived prostaglandin E2 receptor 2 (EP2) is reduced in patients with recurrent miscarriage and EP2 regulates cell proliferation and expression of inflammatory cytokines J Reprod Immunol, 142(0):103210.
PMID: 33011635
Species: Human
Sample Types: Cell Cultue Supernates

G Thomas et al. (2020-01-01), LMWF5A suppresses cytokine release by modulating select inflammatory transcription factor activity in stimulated PBMC Journal of Translational Medicine, 18(1):452.
PMID: 33256749
Species: Human
Sample Types: Plasma

HH Park et al. (2020-01-01), Acetylated K676 TGFBIp as a severity diagnostic blood biomarker for SARS-CoV-2 pneumonia Sci Adv, 6(31).
PMID: 32937590
Species: Human
Sample Types: Cell Culture Supernates

A Santarsier et al. (2020-01-01), Pistacia lentiscus Hydrosol: Untargeted Metabolomic Analysis and Anti-Inflammatory Activity Mediated by NF-&kappaB and the Citrate Pathway Oxid Med Cell Longev, 2020(0):4264815.
PMID: 33204395
Species: Human
Sample Types: Cell Culture Supernates

JB Park et al. (2020-01-01), Javamide-II Inhibits IL-6 without Significant Impact on TNF-alpha and IL-1beta in Macrophage-Like Cells Biomedicines, 8(6).
PMID: 32485858
Species: Human
Sample Types: CSF

M Saresella et al. (2020-01-01), IL-33 and its decoy sST2 in patients with Alzheimer's disease and mild cognitive impairment J Neuroinflammation, 17(1):174.
PMID: 32505187
Species: Human
Sample Types: Cell Culture Supernates

S Xiong et al. (2020-01-01), IL-1beta suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury J. Clin. Invest., 130(7):3684-3698.
PMID: 32298238
Species: Human
Sample Types: Cell Culture Supernates

J Venkatesh et al. (2020-01-01), Antagonizing binding of cell cycle and apoptosis regulatory protein 1 (CARP-1) to the NEMO/IKKgamma protein enhances the anticancer effect of chemotherapy J. Biol. Chem., 295(11):3532-3552.
PMID: 32024692
Species: Human
Sample Types: Plasma

B Pedraz-Pet et al. (2020-01-01), Pro-inflammatory markers and fatigue in patients with depression: A case-control study Sci Rep, 10(1):9494.
PMID: 32528052
Species: Human
Sample Types: Plasma

M Reale et al. (2020-01-01), Network between Cytokines, Cortisol and Occupational Stress in Gas and Oilfield Workers Int J Mol Sci, 21(3).
PMID: 32046214
Species: Mouse
Sample Types: Cell Culture Supernates

H Tsugawa et al. (2020-01-01), Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection PLoS Biol, 18(9):e3000813.
PMID: 32991574
Species: Human
Sample Types: Cell Culture Supernates

S Sukhanov et al. (2020-01-01), The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1&beta and IL-18 secretion Cell Signal, 77(0):109825.
PMID: 33160017
Species: Human
Sample Types: Serum

MO Kutuk et al. (2020-01-01), Cytokine expression profiles in Autism spectrum disorder: A multi-center study from Turkey Cytokine, 133(0):155152.
PMID: 32563959
Species: Human
Sample Types: Cell Culture Supernates

DC Johnson et al. (2020-01-01), DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes Cell Death Dis, 11(8):628.
PMID: 32796818
Species: Human
Sample Types: Cell Culture Supernates

B Baeza-Raja et al. (2020-01-01), Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis PLoS ONE, 15(6):e0234038.
PMID: 32492075
Species: Human
Sample Types: Plasma

S Xu et al. (2020-01-01), Neonatal hand, foot, and mouth disease due to coxsackievirus A6 in Shanghai BMC Pediatr, 20(1):364.
PMID: 32741368
Species: Human
Sample Types: Cell Culture Supernates, Whole Cells

AA Pinar et al. (2020-01-01), Relaxin Can Mediate Its Anti-Fibrotic Effects by Targeting the Myofibroblast NLRP3 Inflammasome at the Level of Caspase-1 Front Pharmacol, 11(0):1201.
PMID: 32848798
Species: Human
Sample Types: Tissue Lysate

M Pein et al. (2020-01-01), Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs Nat Commun, 11(1):1494.
PMID: 32198421
Species: Human
Sample Types: Tissue Homogenates

SA Ingelse et al. (2019-01-01), Fluid restriction reduces pulmonary edema in a model of acute lung injury in mechanically ventilated rats PLoS ONE, 14(1):e0210172.
PMID: 30653512
Species: Human
Sample Types: Cell Culture Supernates

N Takamura et al. (2019-01-01), Downregulated Caveolin-1 expression in circulating monocytes may contribute to the pathogenesis of psoriasis Sci Rep, 9(1):125.
PMID: 30644419
Species: Human
Sample Types: Cell Culture Supernates

J Li et al. (2019-01-01), Theaflavins prevent cartilage degeneration via AKT/FOXO3 signaling inï¿½vitro Mol Med Rep, 19(2):821-830.
PMID: 30569095
Species: Human
Sample Types: Cell Lysates

Y Imai et al. (2019-01-01), Stimulated hepatic stellate cell promotes progression of hepatocellular carcinoma due to protein kinase R activation PLoS ONE, 14(2):e0212589.
PMID: 30794626
Species: Human
Sample Types: Cell Culture Supernates

L Jiang et al. (2019-01-01), The Pros1/Tyro3 axis protects against periodontitis by modulating STAT/SOCS signalling J. Cell. Mol. Med., 0(0).
PMID: 30729671
Species: Human
Sample Types: Cell Culture Supernates

YS Ryu et al. (2019-01-01), Particulate matter induces inflammatory cytokine production via activation of NF?B by TLR5-NOX4-ROS signaling in human skin keratinocyte and mouse skin Redox Biol, 21(0):101080.
PMID: 30584981
Species: Human
Sample Types: Cell Culture Supernates

M Yamaya et al. (2019-01-01), Effects of high temperature on pandemic and seasonal human influenza viral replication and infection-induced damage in primary human tracheal epithelial cell cultures Heliyon, 5(2):e01149.
PMID: 30839917
Species: Human
Sample Types: Cell Culture Supernates

S Suzuki et al. (2019-01-01), Dental pulp cell-derived powerful inducer of TNF-? comprises PKR containing stress granule rich microvesicles Sci Rep, 9(1):3825.
PMID: 30846715
Species: Human
Sample Types: Cell Culture Supernates

TAT Tran et al. (2019-01-01), Whole blood assay as a model for in vitro evaluation of inflammasome activation and subsequent caspase-mediated interleukin-1 beta release PLoS ONE, 14(4):e0214999.
PMID: 30958862
Species: Human
Sample Types: Cell Culture Supernates

F De Felice et al. (2019-01-01), Sulodexide counteracts endothelial dysfunction induced by metabolic or non-metabolic stresses through activation of the autophagic program Eur Rev Med Pharmacol Sci, 23(6):2669-2680.
PMID: 30964194
Species: Human
Sample Types: Serum

AT Peters et al. (2019-01-01), Interplay between pro-inflammatory cytokines, childhood trauma, and executive function in depressed adolescents J Psychiatr Res, 114(0):1-10.
PMID: 30978658
Species: Human
Sample Types: Serum

Z Li et al. (2019-01-01), Genome-wide association study in Turkish and Iranian populations identify rare familial Mediterranean fever gene (MEFV) polymorphisms associated with ankylosing spondylitis PLoS Genet., 15(4):e1008038.
PMID: 30946743
Species: Human
Sample Types: Cell Culture Supernates

R Chen et al. (2019-01-01), cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis Sci Adv, 5(5):eaav5562.
PMID: 31131320
Species: Human
Sample Types: Bone Marrow Fluid

T Sun et al. (2019-01-01), Multilevel defects in the hematopoietic niche in essential thrombocythemia Haematologica, 0(0).
PMID: 31289202
Species: Human
Sample Types: Serum

MW Han et al. (2019-01-01), Serum IL-1 Î² can be a biomarker in children with severe persistent allergic rhinitis Allergy Asthma Clin Immunol, 15(0):58.
PMID: 31548841
Species: Human
Sample Types: Plasma

IS Ribeiro et al. (2019-01-01), Association between body composition and inflammation: A central role of IL-17 and IL-10 in diabetic and hypertensive elderly women Exp. Gerontol., 127(0):110734.
PMID: 31518664
Species: Human
Sample Types: Cell Culture Supernates

SJ Park et al. (2019-01-01), Epigenetic downregulation of STAT6 increases HIF-1Î± expression via mTOR/S6K/S6, leading to enhanced hypoxic viability of glioma cells Acta Neuropathol Commun, 7(1):149.
PMID: 31530290
Species: Human
Sample Types: Cell Culture Supernates

X Zhang et al. (2019-01-01), Cancer-associated fibroblast stimulates cancer cell invasion in an interleukin-1 receptor (IL-1R)-dependent manner Oncol Lett, 18(5):4645-4650.
PMID: 31611973
Species: Human
Sample Types: Cell Culture Supernates

T Sato et al. (2019-01-01), Stimulation of Phagocytic Activity in Cultured Human Corneal Fibroblasts by Plasminogen Invest. Ophthalmol. Vis. Sci., 60(13):4205-4214.
PMID: 31618424
Species: Human
Sample Types: Cell Culture Supernates

WZ Ying et al. (2019-01-01), Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury J. Clin. Invest., 129(7):2792-2806.
PMID: 31205024
Species: Human
Sample Types: Serum

AM Moro et al. (2019-01-01), Evaluation of immunological, inflammatory, and oxidative stress biomarkers in gasoline station attendants BMC Pharmacol Toxicol, 20(0):75.
PMID: 31852532
Species: Human
Sample Types: Cell Culture Supernates

T Ieda et al. (2019-01-01), Visualization of epithelial-mesenchymal transition in an inflammatory microenvironment-colorectal cancer network Sci Rep, 9(1):16378.
PMID: 31705021
Species: Human
Sample Types: Plasma

Y He et al. (2019-01-01), Inhibition of Triggering Receptor Expressed on Myeloid Cell-1 Alleviates Acute Gouty Inflammation Mediators Inflamm., 2019(0):5647074.
PMID: 31885496
Species: Human
Sample Types: Plasma

JH Bae et al. (2019-01-01), Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes Cells, 8(4).
PMID: 30965677
Species: Human
Sample Types: Cell Culture Supernates

JK Thompson et al. (2018-01-01), Extracellular signal regulated kinase 5 and inflammasome in progression of mesothelioma Oncotarget, 9(1):293-305.
PMID: 29416614
Species: Human
Sample Types: Vitreous Humor

T Tsai et al. (2018-01-01), Anti-inflammatory cytokine and angiogenic factors levels in vitreous samples of diabetic retinopathy patients PLoS ONE, 13(3):e0194603.
PMID: 29584759
Species: Human
Sample Types: Cell Culture Supernates

CJ Chen et al. (2018-01-01), ABCG2 contributes to the development of gout and hyperuricemia in a genome-wide association study Sci Rep, 8(1):3137.
PMID: 29453348
Species: Human
Sample Types: Cell Culture Supernates

T Yamamoto et al. (2018-01-01), Effects of loxoprofen on the apical root resorption during orthodontic tooth movement in rats PLoS ONE, 13(4):e0194453.
PMID: 29694352
Species: Human
Sample Types: Cell Culture Supernates

TTY Wang et al. (2018-01-01), Elucidating the Role of CD84 and AHR in Modulation of LPS-Induced Cytokines Production by Cruciferous Vegetable-Derived Compounds Indole-3-Carbinol and 3,3'-Diindolylmethane Int J Mol Sci, 19(2).
PMID: 29364159
Species: Human
Sample Types: Cell Culture Supernates

D Westmeier et al. (2018-01-01), Nanoparticle decoration impacts airborne fungal pathobiology Proc. Natl. Acad. Sci. U.S.A., 0(0).
PMID: 29925597
Species: Human
Sample Types: Cell Culture Supernates

SD Hiller et al. (2018-01-01), ?-Nicotinamide Adenine Dinucleotide (?-NAD) Inhibits ATP-Dependent IL-1? Release from Human Monocytic Cells Int J Mol Sci, 19(4).
PMID: 29642561
Species: Human
Sample Types: Serum

LG Coleman et al. (2018-01-01), HMGB1/IL-1? complexes in plasma microvesicles modulate immune responses to burn injury PLoS ONE, 13(3):e0195335.
PMID: 29601597
Species: Human
Sample Types: Plasma

W Coryell et al. (2018-01-01), Aggression, impulsivity and inflammatory markers as risk factors for suicidal behavior J Psychiatr Res, 106(0):38-42.
PMID: 30261413
Species: Human
Sample Types: Cell Culture Supernates

B Stapel et al. (2018-01-01), Second generation atypical antipsychotics olanzapine and aripiprazole reduce expression and secretion of inflammatory cytokines in human immune cells J Psychiatr Res, 105(0):95-102.
PMID: 30216787
Species: Human
Sample Types: Cell Culture Supernates

H Bai et al. (2018-01-01), Downregulation of signal transduction and STAT3 expression exacerbates oxidative stress mediated by NLRP3 inflammasome Neural Regen Res, 13(12):2147-2155.
PMID: 30323145
Species: Human
Sample Types: Cell Culture Supernates

Y Wang et al. (2018-01-01), Dysfunctional endothelial-derived microparticles promote inflammatory macrophage formation via NF-?B and IL-1? signal pathways J. Cell. Mol. Med., 0(0).
PMID: 30334371
Species: Human
Sample Types: Serum

Y Li et al. (2018-01-01), TRAF3-interacting JNK-activating modulator promotes inflammation by stimulatingï¿½ translocation of Toll-like receptor 4 to lipid rafts J. Biol. Chem., 0(0).
PMID: 30573680
Species: Human
Sample Types: Cell Culture Supernates

Y Tanaka et al. (2018-01-01), Tryptophan Photoproduct FICZ Upregulates IL1A, IL1B, and IL6 Expression via Oxidative Stress in Keratinocytes Oxid Med Cell Longev, 2018(0):9298052.
PMID: 30595799
Species: Rat
Sample Types: Serum

Sandeep Kumar Vishwakarm et al. (2018-01-01), Bioengineering Human Neurological Constructs Using Decellularized Meningeal Scaffolds for Application in Spinal Cord Injury. Frontiers in Bioengineering and Biotechnology, 0(0):2296-4185.
PMID: 30443545
Species: Human
Sample Types: Cell Culture Supernates

VS Simons et al. (2018-01-01), Comparative Analysis of Peptide Composition and Bioactivity of Different Collagen Hydrolysate Batches on Human Osteoarthritic Synoviocytes Sci Rep, 8(1):17733.
PMID: 30531866
Species: Human
Sample Types: Serum

AE Stanciu et al. (2018-01-01), NT-proBNP and CA 125 levels are associated with increased pro-inflammatory cytokines in coronary sinus serum of patients with chronic heart failure Cytokine, 111(0):13-19.
PMID: 30098475
Species: Human
Sample Types: Cell Culture Supernates

B Knoops et al. (2018-01-01), Specific Interactions Measured by AFM on Living Cells between Peroxiredoxin-5 and TLR4: Relevance for Mechanisms of Innate Immunity Cell Chem Biol, 0(0).
PMID: 29551349
Species: Human
Sample Types: THP-1 cells

HJ Park et al. (2018-01-01), Adipose-derived stem cells ameliorate colitis by suppression of inflammasome formation and regulation of M1-macrophage population through prostaglandin E2 Biochem. Biophys. Res. Commun., 0(0).
PMID: 29550474
Species: Human
Sample Types: Gingival Crevicular Fluid

C Bersezio et al. (2018-01-01), Does the Use of a "Walking Bleaching" Technique Increase Bone Resorption Markers? Oper Dent, 0(0).
PMID: 29533717
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Capture

UT Timur et al. (2018-01-01), Celecoxib-mediated reduction of prostanoid release in Hoffa's fat pad from donors with cartilage pathology results in an attenuated inflammatory phenotype Osteoarthr. Cartil., 0(0).
PMID: 29426013
Species: Human
Sample Types: Serum
Applications: ELISA Capture

I Bellinghau et al. (2018-01-01), Wheat amylase/trypsin inhibitors exacerbate intestinal and airway allergic immune responses in humanized mice J. Allergy Clin. Immunol., 0(0).
PMID: 29574077
Species: Human
Sample Types: Cell Culture Supernates

TD Jung et al. (2018-01-01), Changes in the Anti-Allergic Activities of Sesame by Bioconversion Nutrients, 10(2).
PMID: 29443928
Species: Human
Sample Types: Cell Culture Supernates

RJW Arts et al. (2018-01-01), BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity Cell Host Microbe, 23(1):89-100.e5.
PMID: 29324233
Species: Human
Sample Types: Cell Culture Supernates

A Zakrzewicz et al. (2017-01-01), Canonical and Novel Non-Canonical Cholinergic Agonists Inhibit ATP-Induced Release of Monocytic Interleukin-1? via Different Combinations of Nicotinic Acetylcholine Receptor Subunits ?7, ?9 and ?10 Front Cell Neurosci, 11(0):189.
PMID: 28725182
Species: Human
Sample Types: Tissue Culture Supernates

M Lombardi et al. (2017-01-01), P2X7 receptor antagonism modulates IL-1? and MMP9 in human atherosclerotic vessels Sci Rep, 7(1):4872.
PMID: 28687781
Species: Human
Sample Types: Cell Culture Supernates

S Li et al. (2017-01-01), The long non-coding RNA TP73-AS1 modulates HCC cell proliferation through miR-200a-dependent HMGB1/RAGE regulation J. Exp. Clin. Cancer Res., 36(1):51.
PMID: 28403886
Species: Human
Sample Types: Serum

S Grygorczuk et al. (2017-01-01), The increased concentration of macrophage migration inhibitory factor in serum and cerebrospinal fluid of patients with tick-borne encephalitis J Neuroinflammation, 14(1):126.
PMID: 28646884
Species: Human
Sample Types: Cell Culture Supernates

X Yang et al. (2017-01-01), Surfactant protein A is expressed in the central nervous system of rats with experimental autoimmune encephalomyelitis, and suppresses inflammation in human astrocytes and microglia Mol Med Rep, 0(0).
PMID: 28393255
Species: Human
Sample Types: Serum

Z Meng et al. (2017-01-01), High serum resistin associates with intrahepatic inflammation and necrosis: an index of disease severity for patients with chronic HBV infection BMC Gastroenterol, 17(1):6.
PMID: 28061755
Species: Human
Sample Types: Cell Culture Supernates

T Nakamura et al. (2017-01-01), Age-related increase in Wnt inhibitor causes a senescence-like phenotype in human cardiac stem cells Biochem. Biophys. Res. Commun., 0(0).
PMID: 28435069
Species: Human
Sample Types: Complex Sample Type

D Heftrig et al. (2017-01-01), Impaired Surface Expression of HLA-DR, TLR2, TLR4, and TLR9 in Ex Vivo-In Vitro Stimulated Monocytes from Severely Injured Trauma Patients Mediators Inflamm, 2017(0):2608349.
PMID: 28255201
Species: Human
Sample Types: Synovial Fluid

K Kobayashi et al. (2017-01-01), Elastin?derived peptides are involved in the processes of human temporomandibular disorder by inducing inflammatory responses in synovial cells Mol Med Rep, 16(3):3147-3154.
PMID: 28714016
Species: Human
Sample Types: Cell Culture Supernates

F La Rosa et al. (2017-01-01), Immune and Imaging Correlates of Mild Cognitive Impairment Conversion to Alzheimer's Disease Sci Rep, 7(1):16760.
PMID: 29196629
Species: Human
Sample Types: Serum

D Šumanovi?- et al. (2017-01-01), A comparison of blood and cerebrospinal fluid cytokines (IL-1?, IL-6, IL-18, TNF-?) in neonates with perinatal hypoxia Bosn J Basic Med Sci, 0(0).
PMID: 28418828
Species: Human
Sample Types: Cell Culture Supernates

R Dornhof et al. (2017-01-01), Stress fibers, autophagy and necrosis by persistent exposure to PM2.5 from biomass combustion PLoS ONE, 12(7):e0180291.
PMID: 28671960
Species: Human
Sample Types: Cell Culture Supernates

Y Torii et al. (2017-01-01), Epstein-Barr virus infection-induced inflammasome activation in human monocytes PLoS ONE, 12(4):e0175053.
PMID: 28369146
Species: Human
Sample Types: Tissue Homogenates

GN Pandey et al. (2017-01-01), Abnormal gene and protein expression of inflammatory cytokines in the postmortem brain of schizophrenia patients Schizophr. Res., 0(0).
PMID: 28476335
Species: Human
Sample Types: Tissue Homogenates

D Daley-Brow et al. (2017-01-01), Type II Endometrial Cancer Overexpresses NILCO: A Preliminary Evaluation Dis. Markers, 2017(0):8248175.
PMID: 28659656
Species: Mouse
Sample Types: Cell Culture Supernates

X Gu (2016-01-01), Glucagon-like peptide 1 improves insulin resistance in vitro through anti-inflammation of macrophages Braz. J. Med. Biol. Res., 49(12):e5826.
PMID: 27878229
Species: Human
Sample Types: Tissue Culture Supernates

S Mairpady S et al. (2016-01-01), A point mutation in AgrC determines cytotoxic or colonizing properties associated with phenotypic variants of ST22 MRSA strains Sci Rep, 6(0):31360.
PMID: 27511873
Species: Human
Sample Types: Serum

(2016-01-01), Cell surface-anchored syndecan-1 ameliorates intestinal inflammation and neutrophil transmigration in ulcerative colitis J Cell Mol Med, 0(0).
PMID: 27558380
Species: Human
Sample Types: Plasma

(2016-01-01), Association between mannose-binding lectin variants, haplotypes and risk of hepatocellular carcinoma: A case-control study Sci Rep, 6(0):32147.
PMID: 27557564
Species: Human
Sample Types: Cell Culture Supernates

Pranav Murthy (2016-01-01), The NLRP3 inflammasome and bruton's tyrosine kinase in platelets co-regulate platelet activation, aggregation, and inï¿½vitro thrombus formation Biochem. Biophys. Res. Commun, 0(0).
PMID: 28034752
Species: Human
Sample Types: Cell Culture Supernates

JH Kim et al. (2016-01-01), NLRP3 Inflammasome Activation in THP-1 Target Cells Triggered by Pathogenic Naegleria fowleri Infect. Immun, 84(9):2422-8.
PMID: 27297387
Species: Human
Sample Types: Plasma

(2016-01-01), Innovative Flow Cytometry Allows Accurate Identification of Rare Circulating Cells Involved in Endothelial Dysfunction PLoS ONE, 11(8):e0160153.
PMID: 27560136
Species: Human
Sample Types: Saliva

Z Nazar Maje et al. (2016-01-01), Identification of Gingival Crevicular Fluid Sampling, Analytical Methods, and Oral Biomarkers for the Diagnosis and Monitoring of Periodontal Diseases: A Systematic Review Dis. Markers, 2016(0):1804727.
PMID: 28074077
Species: Human
Sample Types: Cell Culture Supernates

(2016-01-01), Cross-talk between intestinal epithelial cells and immune cells in inflammatory bowel disease Sci Rep, 6(0):29783.
PMID: 27417573
Species: Human
Sample Types: Serum

El?bieta Radzikowsk (2016-01-01), Clarithromycin Decreases IL-6 Concentration in Serum and BAL Fluid in Patients with Cryptogenic Organizing Pneumonia Adv Clin Exp Med, 25(5):871-878.
PMID: 28028949
Species: Human
Sample Types: Cell Culture Supernates

Tatsuya Hasegawa (2016-01-01), Nuclear DNA damage-triggered NLRP3 inflammasome activation promotes UVB-induced inflammatory responses in human keratinocytes Biochem Biophys Res Commun, 0(0).
PMID: 27343554
Species: Human
Sample Types: Serum

AF Al-Kholy et al. (2016-01-01), Pre-treatment serum inflammatory cytokines as survival predictors of patients with nasopharyngeal carcinoma receiving chemoradiotherapy Mol Clin Oncol, 5(6):811-816.
PMID: 28105362
Species: Human
Sample Types: Plasma, Serum

Aldo P et al. (2016-01-01), Simple Plex() : A Novel Multi-Analyte, Automated Microfluidic Immunoassay Platform for the Detection of Human and Mouse Cytokines and Chemokines. Am J Reprod Immunol, 75(6):678-93.
PMID: 27170460
Species: Human
Sample Types: Cell Culture Supernates

Qing Li (2016-01-01), Novel high throughput pooled shRNA screening identifies NQO1 as a potential drug target for host directed therapy for tuberculosis Sci Rep, 6(0):27566.
PMID: 27297123
Species: Human
Sample Types: Cell Culture Supernates

(2016-01-01), Activation and IL-1? secretion of human peripheral phagocytes infected with Actinomadura madurae, Nocardia asteroides and Candida albicans Asian Pac J Trop Med, 9(10):962-967.
PMID: 27794389
Species: Human
Sample Types: Plasma

Chun Li (2016-01-01), Circulating Fibrocytes Are Increased in Neonates with Bronchopulmonary Dysplasia PLoS ONE, 11(6):e0157181.
PMID: 27309347
Species: Human
Sample Types: Cell Culture Supernates

Shipkowski K et al. (2015-01-01), An Allergic Lung Microenvironment Suppresses Carbon Nanotube-Induced Inflammasome Activation via STAT6-Dependent Inhibition of Caspase-1. PLoS ONE, 10(6):e0128888.
PMID: 26091108
Species: Human
Sample Types: Cell Culture Supernates

Grodzki A et al. (2015-01-01), A novel carboline derivative inhibits nitric oxide formation in macrophages independent of effects on tumor necrosis factor alpha and interleukin-1beta expression. J Pharmacol Exp Ther, 352(3):438-47.
PMID: 25538105
Species: Human
Sample Types: Cell Culture Supernates

Sokolowska M et al. (2015-01-01), Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages. J Immunol, 194(11):5472-87.
PMID: 25917098
Species: Human
Sample Types: Cell Culture Supernates

Hecker A et al. (2015-01-01), Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1beta Release. J Immunol, 195(5):2325-34.
PMID: 26202987
Species: Human
Sample Types: Cell Culture Supernates

Shenker B et al. (2015-01-01), Aggregatibacter actinomycetemcomitans cytolethal distending toxin activates the NLRP3 inflammasome in human macrophages, leading to the release of proinflammatory cytokines. Infect Immun, 83(4):1487-96.
PMID: 25644004
Species: Human
Sample Types: Cell Culture Supernates

Koch A et al. (2015-01-01), MyD88-Dependent Signaling Decreases the Antitumor Efficacy of Epidermal Growth Factor Receptor Inhibition in Head and Neck Cancer Cells. Cancer Res, 75(8):1657-67.
PMID: 25712126
Species: Human
Sample Types: Cell Culture Supernates

Alfaidi M et al. (2015-01-01), Neutrophil elastase promotes interleukin-1beta secretion from human coronary endothelium. J Biol Chem, 290(40):24067-78.
PMID: 26269588
Species: Human
Sample Types: Cell Culture Supernates

Tokumoto M et al. (2015-01-01), Identification of tumour-reactive lymphatic endothelial cells capable of inducing progression of gastric cancer. Br J Cancer, 113(7):1046-54.
PMID: 26355233
Species: Human
Sample Types: Cell Culture Supernates

Datta-Mitra A et al. (2015-01-01), Cross talk between neuroregulatory molecule and monocyte: nerve growth factor activates the inflammasome. PLoS ONE, 10(4):e0121626.
PMID: 25876154
Species: Human
Sample Types: BALF

Chou C et al. (2014-01-01), The impact of concomitant pulmonary infection on immune dysregulation in Pneumocystis jirovecii pneumonia. BMC Pulm Med, 14(0):182.
PMID: 25409888
Species: Human
Sample Types: Cell Culture Supernates

Fuentes E et al. (2014-01-01), Chlorogenic acid inhibits human platelet activation and thrombus formation. PLoS ONE, 9(3):e90699.
PMID: 24598787
Species: Human
Sample Types: Serum

Altara et al. (2014-01-01), Improving membrane based multiplex immunoassays for semi-quantitative detection of multiple cytokines in a single sample. BMC Biotechnol, 14(0):63.
PMID: 25022797
Species: Human
Sample Types: Plasma

Kawamura T et al. (2014-01-01), Effect of renal impairment on cognitive function during a 3-year follow up in elderly patients with type 2 diabetes: Association with microinflammation. J Diabetes Investig, 5(5):597-605.
PMID: 25411629
Species: Human
Sample Types: Cell Culture Supernates

Glorieux et al. (2014-01-01), Looking beyond endotoxin: a comparative study of pyrogen retention by ultrafilters used for the preparation of sterile dialyis fluid. Sci Rep, 4(0):6390.
PMID: 25227511
Species: Human
Sample Types: Cell Culture Supernates

Yoshida K et al. (2014-01-01), Preventive effect of Daiokanzoto (TJ-84) on 5-fluorouracil-induced human gingival cell death through the inhibition of reactive oxygen species production. PLoS ONE, 9(11):e112689.
PMID: 25389767
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Tissue Homogenates

Hirao L et al. (2014-01-01), Early mucosal sensing of SIV infection by paneth cells induces IL-1beta production and initiates gut epithelial disruption. PLoS Pathog, 10(8):e1004311.
PMID: 25166758
Species: Human
Sample Types: Cell Culture Supernates

Zhang Y et al. (2014-01-01), Expression and functional characterization of NOD2 in decidual stromal cells isolated during the first trimester of pregnancy. PLoS ONE, 9(6):e99612.
PMID: 24932916
Species: Human
Sample Types: Cell Culture Supernates

Westbom C et al. (2014-01-01), CREB-induced inflammation is important for malignant mesothelioma growth. Am J Pathol, 184(10):2816-27.
PMID: 25111229
Species: Human
Sample Types: Cell Culture Supernates

Endo Y et al. (2014-01-01), Differences in PGE2 production between primary human monocytes and differentiated macrophages: role of IL-1beta and TRIF/IRF3. PLoS ONE, 9(5):e98517.
PMID: 24870145
Species: Human
Sample Types: Plasma

Vambutas A et al. (2014-01-01), Early efficacy trial of anakinra in corticosteroid-resistant autoimmune inner ear disease. J Clin Invest, 124(9):4115-22.
PMID: 25133431
Species: Human
Sample Types: Cell Culture Supernates

Naik et al. (2014-01-01), Oxidative and pro-inflammatory impact of regular and denicotinized cigarettes on blood brain barrier endothelial cells: is smoking reduced or nicotine-free products really safe? BMC Neurosci, 15(0):51.
PMID: 24755281
Species: Human
Sample Types: Serum

Henninger A et al. (2014-01-01), Adipocyte hypertrophy, inflammation and fibrosis characterize subcutaneous adipose tissue of healthy, non-obese subjects predisposed to type 2 diabetes. PLoS ONE, 9(8):e105262.
PMID: 25148116
Species: Human
Sample Types: Plasma

Tuttolomondo A et al. (2014-01-01), Immune-inflammatory markers and arterial stiffness indexes in subjects with acute ischemic stroke with and without metabolic syndrome. Diabetol Metab Syndr, 6(1):28.
PMID: 24571954
Species: Human
Sample Types: Cell Culture Supernates

Bonfim-Mendonca P et al. (2014-01-01), beta-glucan induces reactive oxygen species production in human neutrophils to improve the killing of Candida albicans and Candida glabrata isolates from vulvovaginal candidiasis. PLoS ONE, 9(9):e107805.
PMID: 25229476
Species: Human
Sample Types: Tissue Homogenates

Ho I et al. (2013-01-01), Human bone marrow-derived mesenchymal stem cells suppress human glioma growth through inhibition of angiogenesis. Stem Cells, 31(1):146-55.
PMID: 23034897
Species: Human
Sample Types: Cell Culture Supernates

Wu M et al. (2013-01-01), CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages. Blood, 121(1):95-106.
PMID: 23152543
Species: Human
Sample Types: Cell Culture Supernates

L'homme L et al. (2013-01-01), Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages. J Lipid Res, 54(11):2998-3008.
PMID: 24006511
Species: Human
Sample Types: CSF

Salsano et al. (2013-01-01), An autoinflammatory neurological disease due to interleukin 6 hypersecretion. J Neuroinflammation, 10(0):29.
PMID: 23432807
Species: Human
Sample Types: Saliva

Jaedicke KM et al. (2012-01-01), Validation and quality control of ELISAs for the use with human saliva samples. J. Immunol. Methods, 377(1):62-5.
PMID: 22306358
Species: Human
Sample Types: Cell Culture Supernates

(2012-01-01), A novel small molecule, HK-156, inhibits lipopolysaccharide-induced activation of NF-kappaB signaling and improves survival in mouse models of sepsis. Acta Pharmacol. Sin., 33(9):1204-16.
PMID: 22684031
Species: Human
Sample Types: Cell Culture Supernates

Huang T et al. (2012-01-01), The anti-tumorigenic mushroom Agaricus blazei Murill enhances IL-1beta production and activates the NLRP3 inflammasome in human macrophages. PLoS ONE, 7(7):e41383.
PMID: 22844468
Species: Human
Sample Types: Sputum

Pauwels NS et al. (2011-01-01), Role of IL-1alpha and the Nlrp3/caspase-1/IL-1beta axis in cigarette smoke-induced pulmonary inflammation and COPD. Eur. Respir. J., 38(5):1019-28.
PMID: 21622588
Species: Human
Sample Types: Cell Culture Supernates

Liu N et al. (2011-01-01), High levels of beta-catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical Wnt pathway. J. Bone Miner. Res., 26(9):2082-95.
PMID: 21638320
Species: Human
Sample Types: Plasma

Pathak S et al. (2011-01-01), IL-1beta is overexpressed and aberrantly regulated in corticosteroid nonresponders with autoimmune inner ear disease. J. Immunol., 186(3):1870-9.
PMID: 21199898
Species: Human
Sample Types: Serum

Thacker SG et al. (2010-01-01), The detrimental effects of IFN-alpha on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction. J. Immunol., 185(7):4457-69.
PMID: 20805419
Species: Human
Sample Types: Tissue Homogenates

Bachert C et al. (2010-01-01), Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma. J. Allergy Clin. Immunol., 126(5):962.
PMID: 20810157
Species: Human
Sample Types: Cell Culture Supernates

Cho MH et al. (2010-01-01), Bacillus anthracis capsule activates caspase-1 and induces interleukin-1beta release from differentiated THP-1 and human monocyte-derived dendritic cells. Infect. Immun., 78(1):387-92.
PMID: 19737897
Species: Human
Sample Types: Plasma

Pinto A et al. (2009-01-01), Immuno-inflammatory predictors of stroke at follow-up in patients with chronic non-valvular atrial fibrillation (NVAF). Clin. Sci., 116(10):781-9.
PMID: 18980576
Species: Human
Sample Types: Plasma

Jaiyen Y et al. (2009-01-01), Characteristics of dengue virus-infected peripheral blood mononuclear cell death that correlates with the severity of illness. Microbiol. Immunol., 53(8):442-50.
PMID: 19659928
Species: Human
Sample Types: Cell Culture Supernates

Boniface K et al. (2009-01-01), Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling. J. Exp. Med., 206(3):535-48.
PMID: 19273625
Species: Human
Sample Types: Plasma

Tuttolomondo A et al. (2009-01-01), Immuno-inflammatory and thrombotic/fibrinolytic variables associated with acute ischemic stroke diagnosis. Atherosclerosis, 203(2):503-8.
PMID: 18715563
Species: Human
Sample Types: Cell Culture Supernates

Semiramoth N et al. (2009-01-01), Escherichia coli type 1 pili trigger late IL-8 production by neutrophil-like differentiated PLB-985 cells through a Src family kinase- and MAPK-dependent mechanism. J. Leukoc. Biol., 85(2):310-21.
PMID: 19015376
Species: Human
Sample Types: Serum

Dossus L et al. (2009-01-01), Validity of multiplex-based assays for cytokine measurements in serum and plasma from "non-diseased" subjects: comparison with ELISA. J. Immunol. Methods, 350(1):125-32.
PMID: 19748508
Species: Human
Sample Types: Cell Culture Supernates

Duncan JA et al. (2009-01-01), Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome. J. Immunol., 182(10):6460-9.
PMID: 19414800
Species: Human
Sample Types: Cell Culture Supernates

Rehani K et al. (2009-01-01), Toll-like receptor-mediated production of IL-1Ra is negatively regulated by GSK3 via the MAPK ERK1/2. J. Immunol., 182(1):547-53.
PMID: 19109187
Kreeger PK et al. (2009-01-01), RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects. Cancer Res., 69(20):8191-9.
PMID: 19789336
Species: Human
Sample Types: Cell Culture Supernates

Chase JC et al. (2009-01-01), Direct and indirect impairment of human dendritic cell function by virulent Francisella tularensis Schu S4. Infect. Immun., 77(1):180-95.
PMID: 18981246
Species: Human
Sample Types: Synovial Fluid

Elsaid KA et al. (2008-01-01), Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury. Arthritis Rheum., 58(6):1707-15.
PMID: 18512776
Species: Human
Sample Types: Reference Standard

Fichorova RN et al. (2008-01-01), Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: a multicenter study. Anal. Chem., 80(12):4741-51.
PMID: 18484740
Species: Human
Sample Types: Cell Culture Supernates

Olsnes AM et al. (2008-01-01), In vitro induction of a dendritic cell phenotype in primary human acute myelogenous leukemia (AML) blasts alters the chemokine release profile and increases the levels of T cell chemotactic CCL17 and CCL22. J. Interferon Cytokine Res., 28(5):297-310.
PMID: 18547160
Species: Human
Sample Types: Cell Culture Supernates

Chang EJ et al. (2008-01-01), The role of nerve growth factor in hyperosmolar stress induced apoptosis. J. Cell. Physiol., 216(1):69-77.
PMID: 18300262
Species: Human
Sample Types: Synovial Fluid

Rihl M et al. (2008-01-01), Identification of interleukin-7 as a candidate disease mediator in spondylarthritis. Arthritis Rheum., 58(11):3430-5.
PMID: 18975340
Species: Human
Sample Types: Cell Culture Supernates

Nah SS et al. (2007-01-01), Advanced glycation end products increases matrix metalloproteinase-1, -3, and -13, and TNF-alpha in human osteoarthritic chondrocytes. FEBS Lett., 581(9):1928-32.
PMID: 17434489
Species: Human
Sample Types: Cell Culture Supernates

Rao DA et al. (2007-01-01), IL-1alpha and IL-1beta are endogenous mediators linking cell injury to the adaptive alloimmune response. J. Immunol., 179(10):6536-46.
PMID: 17982042
Species: Human

Dimberg J et al. (2007-01-01), Expression and gene polymorphisms of the chemokine CXCL5 in colorectal cancer patients. Int. J. Oncol., 31(1):97-102.
PMID: 17549409
Species: Human
Sample Types: Cell Culture Supernates

Liotta F et al. (2007-01-01), Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signaling. Stem Cells, 26(1):279-89.
PMID: 17962701
Species: Human
Sample Types: Whole Cells

Ho CC et al. (2007-01-01), TREM-1 expression in tumor-associated macrophages and clinical outcome in lung cancer. Am. J. Respir. Crit. Care Med., 177(7):763-70.
PMID: 18096709
Species: Human
Sample Types: BALF

Quesnel C et al. (2007-01-01), Regulation of hepatocyte growth factor secretion by fibroblasts in patients with acute lung injury. Am. J. Physiol. Lung Cell Mol. Physiol., 294(2):L334-43.
PMID: 18065658
Species: Human
Sample Types: Follicular Fluid

Asimakopoulos B et al. (2007-01-01), The levels of steroid hormones and cytokines in individual follicles are not associated with the fertilization outcome after intracytoplasmic sperm injection. Fertil. Steril., 90(1):60-4.
PMID: 17980366
Species: Human
Sample Types: Cell Culture Supernates

Nabata A et al. (2007-01-01), C-reactive protein induces endothelial cell apoptosis and matrix metalloproteinase-9 production in human mononuclear cells: Implications for the destabilization of atherosclerotic plaque. Atherosclerosis, 196(1):129-35.
PMID: 17531242
Species: Human
Sample Types: Cell Culture Supernates

Chae JJ et al. (2006-01-01), The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production. Proc. Natl. Acad. Sci. U.S.A., 103(26):9982-7.
PMID: 16785446
Species: Human
Sample Types: Cell Culture Supernates

Hatfield K et al. (2006-01-01), Microvascular endothelial cells increase proliferation and inhibit apoptosis of native human acute myelogenous leukemia blasts. Int. J. Cancer, 119(10):2313-21.
PMID: 16921487
Species: Human
Sample Types: Plasma

Ferrandina G et al. (2006-01-01), Celecoxib up-regulates the expression of the zeta chain of T cell receptor complex in tumor-infiltrating lymphocytes in human cervical cancer. Clin. Cancer Res., 12(7):2055-60.
PMID: 16609015
Species: Human
Sample Types: Plasma

Makis AC et al. (2006-01-01), C-reactive protein and vascular cell adhesion molecule-1 as markers of severity in sickle cell disease. Arch. Intern. Med., 166(3):366-8.
PMID: 16476879
Species: Human
Sample Types: Gingival Crevicular Fluid (GCF)

Johannsen A et al. (2006-01-01), Dental plaque, gingival inflammation, and elevated levels of interleukin-6 and cortisol in gingival crevicular fluid from women with stress-related depression and exhaustion. J. Periodontol., 77(8):1403-9.
PMID: 16937592
Species: Human
Sample Types: Cell Culture Supernates

Coward WR et al. (2006-01-01), Statin-induced proinflammatory response in mitogen-activated peripheral blood mononuclear cells through the activation of caspase-1 and IL-18 secretion in monocytes. J. Immunol., 176(9):5284-92.
PMID: 16621994
Species: Human
Sample Types: Cell Culture Supernates

Peterson ML et al. (2006-01-01), Glycerol monolaurate inhibits the effects of Gram-positive select agents on eukaryotic cells. Biochemistry, 45(7):2387-97.
PMID: 16475828
Species: Human
Sample Types: Cell Culture Supernates

Ehling A et al. (2006-01-01), The potential of adiponectin in driving arthritis. J. Immunol., 176(7):4468-78.
PMID: 16547285
Species: Human
Sample Types: Serum

Holt HB et al. (2006-01-01), Non-esterified fatty acid concentrations are independently associated with hepatic steatosis in obese subjects. Diabetologia, 49(1):141-8.
PMID: 16323001
Species: Human
Sample Types: Cell Culture Supernates

Janes KA et al. (2006-01-01), The response of human epithelial cells to TNF involves an inducible autocrine cascade. Cell, 124(6):1225-39.
PMID: 16564013
Species: Human
Sample Types: Cell Culture Supernates

Marquez-Martin A et al. (2006-01-01), Modulation of cytokine secretion by pentacyclic triterpenes from olive pomace oil in human mononuclear cells. Cytokine, 36(5):211-7.
PMID: 17292619
Species: Human
Sample Types: Cell Culture Supernates

Bengtson SH et al. (2006-01-01), Kinin receptor expression during Staphylococcus aureus infection. Blood, 108(6):2055-63.
PMID: 16735595
Species: Human
Sample Types: Cell Culture Supernates

Skoberne M et al. (2006-01-01), The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function. Blood, 108(3):947-55.
PMID: 16614246
Species: Human
Sample Types: Plasma

Sherman JA et al. (2006-01-01), Humoral and cellular factors responsible for coronary collateral formation. Am. J. Cardiol., 98(9):1194-7.
PMID: 17056326
Species: Human
Sample Types: Cell Culture Supernates

Bartemes KR et al. (2005-01-01), Secretory IgA induces antigen-independent eosinophil survival and cytokine production without inducing effector functions. J. Allergy Clin. Immunol., 116(4):827-35.
PMID: 16210057
Species: Human
Sample Types: Synovial Fluid

Pagura SM et al. (2005-01-01), Circulating and synovial levels of IGF-I, cytokines, physical function and anthropometry differ in women awaiting total knee arthroplasty when compared to men. J. Orthop. Res., 23(2):397-405.
PMID: 15734254
Species: Human
Sample Types: Whole Cells

Witte RP et al. (2005-01-01), Keratinocyte-fibroblast paracrine interaction: the effects of substrate and culture condition. Biomaterials, 26(17):3673-82.
PMID: 15621258
Species: Human
Sample Types: Tears

Manni G et al. (2005-01-01), Interleukin-1beta tear concentration in glaucomatous and ocular hypertensive patients treated with preservative-free nonselective beta-blockers. Am. J. Ophthalmol., 139(1):72-7.
PMID: 15652830
Species: Human
Sample Types: Complex Sample Type

Martis L et al. (2005-01-01), Aseptic peritonitis due to peptidoglycan contamination of pharmacopoeia standard dialysis solution. Lancet, 365(9459):588-94.
PMID: 15708102
Species: Human
Sample Types: Hypersalpingeal Fluid (HSF)

Bedaiwy MA et al. (2005-01-01), Relationship between cytokines and the embryotoxicity of hydrosalpingeal fluid. J. Assist. Reprod. Genet., 22(4):161-5.
PMID: 16021860
Species: Human
Sample Types: Synovial Fluid

Kaneyama K et al. (2005-01-01), Analysis of tumor necrosis factor-alpha, interleukin-6, interleukin-1beta, soluble tumor necrosis factor receptors I and II, interleukin-6 soluble receptor, interleukin-1 soluble receptor type II, interleukin-1 receptor antagonist, and protein in the synovial fluid of patients with temporomandibular joint disorders. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 99(3):276-84.
PMID: 15716832
Species: Rabbit
Sample Types: Tissue Secretion

Branski RC et al. (2005-01-01), Mucosal wound healing in a rabbit model of subglottic stenosis: biochemical analysis of secretions. Arch. Otolaryngol. Head Neck Surg., 131(2):153-7.
PMID: 15723948
Species: Human
Sample Types: Serum

Hayakata T et al. (2004-01-01), Changes in CSF S100B and cytokine concentrations in early-phase severe traumatic brain injury. Shock, 22(2):102-7.
PMID: 15257081
Species: Human
Sample Types: Whole Cells

Brooks-Asplund EM et al. (2004-01-01), Determinants of plasma leptin concentration in postmenopausal women. Mech. Ageing Dev., 125(2):117-9.
PMID: 15037014
Species: Human
Sample Types: Tissue Secretion

Branski RC et al. (2004-01-01), Markers of wound healing in vocal fold secretions from patients with laryngeal pathology. Ann. Otol. Rhinol. Laryngol., 113(1):23-9.
PMID: 14763567
Species: Human
Sample Types: Vaginal Lavage Fluid

Fichorova RN (2004-01-01), Guiding the vaginal microbicide trials with biomarkers of inflammation. J. Acquir. Immune Defic. Syndr., 37(0):S184-93.
PMID: 16419271
Species: Human
Sample Types: Seminal Plasma

Basu S et al. (2004-01-01), Inflammatory cytokine concentrations are elevated in seminal plasma of men with spinal cord injuries. J. Androl., 25(2):250-4.
PMID: 14760011
Species: Human
Sample Types: Tissue Perfusion Fluid

Zilinski JL et al. (2004-01-01), Tissue adhesiveness and host response of in situ photopolymerizable interpenetrating networks containing methylprednisolone acetate. J Biomed Mater Res A, 68(2):392-400.
PMID: 14704982
Species: Human
Sample Types: Gingival Crevicular Fluid (GCF)

Yoshinari N et al. (2004-01-01), Effects of scaling and root planing on the amounts of interleukin-1 and interleukin-1 receptor antagonist and the mRNA expression of interleukin-1beta in gingival crevicular fluid and gingival tissues. J. Periodont. Res., 39(3):158-67.
PMID: 15102044
Species: Human
Sample Types: Gingival Crevicular Fluid (GCF)

Wei PF et al. (2004-01-01), The investigation of glutathione peroxidase, lactoferrin, myeloperoxidase and interleukin-1beta in gingival crevicular fluid: implications for oxidative stress in human periodontal diseases. J. Periodont. Res., 39(5):287-93.
PMID: 15324348
Species: Human
Sample Types: Tissue Secretion

Verdolini K et al. (2003-01-01), Shifts in biochemical markers associated with wound healing in laryngeal secretions following phonotrauma: a preliminary study. Ann. Otol. Rhinol. Laryngol., 112(12):1021-5.
PMID: 14703104
Species: Human
Sample Types: Cell Culture Supernates

Edgeworth JD et al. (2002-01-01), Cytotoxicity and interleukin-1beta processing following Shigella flexneri infection of human monocyte-derived dendritic cells. Eur. J. Immunol., 32(5):1464-71.
PMID: 11981835
Species: Human
Sample Types: Cell Culture Supernates

Hakonarson H et al. (2002-01-01), T lymphocyte-mediated changes in airway smooth muscle responsiveness are attributed to induced autocrine release and actions of IL-5 and IL-1beta. J. Allergy Clin. Immunol., 110(4):624-33.
PMID: 12373272
Species: Human
Sample Types: Ascites Fluid

Marme A et al. (2002-01-01), Intraperitoneal bispecific antibody (HEA125xOKT3) therapy inhibits malignant ascites production in advanced ovarian carcinoma. Int. J. Cancer, 101(2):183-9.
PMID: 12209996
Species: Human
Sample Types: Gingival Crevicular Fluid (GCF)

Jotwani R et al. (2001-01-01), Mature dendritic cells infiltrate the T cell-rich region of oral mucosa in chronic periodontitis: in situ, in vivo, and in vitro studies. 167(8):4693-700.
PMID: 11591800
Species: Human
Sample Types: Cell Culture Supernates

Curti A et al. (2001-01-01), Interleukin-11 induces Th2 polarization of human CD4(+) T cells. Blood, 97(9):2758-63.
PMID: 11313268
Species: Human
Sample Types: Plasma

Carstanjen D et al. (2001-01-01), Interleukin-6 is a major effector molecule of short-term G-CSF treatment inducing bone metabolism and an acute-phase response. Exp. Hematol., 29(7):812-21.
PMID: 11438203
Species: Human
Sample Types: Gut Lavage Fluid

Evgenikos NL et al. (2000-01-01), Luminal neutrophil migration in ileoanal pouches studied by whole gut lavage. Eur J Gastroenterol Hepatol, 12(5):553-7.
PMID: 10833100
Species: Primate - Papio cynocephalus (Yellow Baboon)
Sample Types: Serum

Welty-Wolf KE et al. (2000-01-01), Proinflammatory cytokines increase in sepsis after anti-adhesion molecule therapy. 1-23, 13(5):404-9.
PMID: 10807017
Species: Human
Sample Types: Cell Culture Supernates

Kadowaki N et al. (2000-01-01), Natural interferon alpha/beta-producing cells link innate and adaptive immunity. J. Exp. Med., 192(2):219-26.
PMID: 10899908
Species: Human
Sample Types: Cell Culture Supernates

Attur MG et al. (2000-01-01), Functional genomic analysis in arthritis-affected cartilage: yin-yang regulation of inflammatory mediators by alpha 5 beta 1 and alpha V beta 3 integrins. J. Immunol., 164(5):2684-91.
PMID: 10679109
Species: Human
Sample Types: Gingival Crevicular Fluid (GCF)

Rasmussen L et al. (2000-01-01), Characterization of bone resorbing activity in gingival crevicular fluid from patients with periodontitis. J. Clin. Periodontol., 27(1):41-52.
PMID: 10674961
Species: Human
Sample Types: Cell Culture Supernates

Fadok et al. (1998-01-01), Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest, 101(4):890-8.
PMID: 9466984
Species: Human
Sample Types: Gingival Crevicular Fluid (GCF)

Lerner UH et al. (1998-01-01), Gingival crevicular fluid from patients with periodontitis contains bone resorbing activity. Eur. J. Oral Sci., 106(3):778-87.
PMID: 9672100

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Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Name: Anonymous

Sample Tested: Cell culture supernatant

Verified Customer | Posted 04/24/2023
Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Name: Anonymous

Sample Tested: Urine

Verified Customer | Posted 11/18/2022

Matrix effect detected for the lowest standard in urine diluted 2-fold. Was able to detect low concentrations in urine at 2-fold dilution.
Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Name: Anonymous

Sample Tested: Cell culture supernatant

Verified Customer | Posted 11/05/2018
Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Name: Anonymous

Sample Tested: Serum

Verified Customer | Posted 07/13/2018
Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Name: Anonymous

Sample Tested: Cell Culture Media

Verified Customer | Posted 05/31/2018
Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Name: Anonymous

Sample Tested: Heparin Plasma

Verified Customer | Posted 05/08/2018

Among best ELISAs I've worked with. Great consistency lot to lot, high sensitivity, easy to work with small amount of samples (I've diluted samples 1:100 in the past). Appropriate for concentration response curves. The only thing that can be improved is expanding the dynamic range of the assay (highest standard is at 250pg/ml and in our case we sometimes have 20,000pg/ml so need to make significant dilution to fit within the standard curve).
Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Name: Anonymous

Sample Tested: CHO Chinese hamster ovary cell line

Verified Customer | Posted 04/24/2018
Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Name: Anonymous

Sample Tested: Serum and Plasma

Verified Customer | Posted 04/04/2018
Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Name: Anonymous

Sample Tested: THP-1 human acute monocytic leukemia cell line

Verified Customer | Posted 06/20/2017
Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Name: Mike Ehrhardt

Sample Tested: Serum

Verified Customer | Posted 04/24/2017

The Human IL-1beta Quantikine ELISA kit is used for diagnostic use.
Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Name: Lamberto Torralba

Sample Tested: Peripheral blood mononuclear cells (PBMCs)

Verified Customer | Posted 03/15/2017

Freshly isolated PBMCs from buffy coats stimulated with LPS (1ug/mL) for 3h together with Simvastatin. Total amount of 3 million cells/well. Volume supernatant used: 100uL. Two donors. Great production of IL1B in supernatant. Increased when statins are present as expected. Experiment used as a positive control
Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Name: Anonymous

Sample Tested: uman plasma

Verified Customer | Posted 04/13/2016

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

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Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

Product Documents for Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

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