LY 379268
Tocris Bioscience, part of Bio-Techne | Catalog # 2453
Highly selective group II mGlu agonist
Key Product Details
Description
Highly selective group II mGlu agonist
Product Description
LY 379268 is a highly selective group II mGlu receptor agonist (EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3 respectively) that displays > 80-fold selectivity over group I and group III receptors. Provides protection against NMDA-mediated cell death in vitro and offers almost complete protection against CA1 hippocampal damage following global ischemia in gerbils. Orally and systemically active. LY379268 disodium salt also available.Licensing Information
Sold under license from Eli Lilly and CompanyProduct Specifications
Molecular Weight
187.15
Formula
C7H9NO5
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
(1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
CAS Number
191471-52-0
PubChem ID
10197984
InChI Key
YASVRZWVUGJELU-MDASVERJSA-N
SMILES
[H][C@]12[C@]([C@H]2[C@@](O)=O)([H])[C@](N)([C@](O)=O)CO1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 3.74 | 20 | |
| 1eq. NaOH | 18.71 | 100 |
Preparing Stock Solutions
for LY 379268
The following data is based on the product molecular weight 187.15
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.34 mL | 26.72 mL | 53.43 mL |
| 5 mM | 1.07 mL | 5.34 mL | 10.69 mL |
| 10 mM | 0.53 mL | 2.67 mL | 5.34 mL |
| 50 mM | 0.11 mL | 0.53 mL | 1.07 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bond Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanisms of action in vivo. J.Pharmacol.Exp.Ther. 2000 PMID: 10945827
- Collado (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 agonist with anxiolytic properties. J.Med.Chem. 2002 PMID: 12166935
- Bond LY379268, a potent and selective group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal cerebral ischaemia. Neurosci.Lett. 1999 PMID: 10515191
Product Specific Notices for LY 379268
For research use only
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