TGF-beta 1, 2, 3 Antibody
R&D Systems, Inc. a Bio-Techne Brand
Key Product Details
Immunogen: | Bovine bone-derived TGF-beta 1 and TGF-beta 2 |
Applications: | Block/Neutralize, ELISA Capture, Western Blot |
Label: | Unconjugated |
Source: | Monoclonal Mouse IgG1 Clone # 1D11 |
Specificity: |
Detects bovine, chicken, mouse, and human TGF-beta in ELISAs and Western blots. It recognizes human TGF-beta 1, TGF-beta 2, and TGF-beta 3. No cross-reactivity was observed with recombinant LAP in direct ELISAs. |
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Citations for TGF-beta 1, 2, 3 Antibody (156)
Citations are publications that use Bio-Techne products. Selected citations for TGF-beta 1, 2, 3 Antibody include:
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Species: Human
Sample Types: Whole Cells
Applications: NeutralizationGN Yin et al. (2022), Latrophilin-2 is a novel receptor of LRG1 that rescues vascular and neurological abnormalities and restores diabetic erectile function Experimental Molecular Medicine, 2022;0(0).
PMID: 35562586 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationJ Hanna et al. (2022), Cell-autonomous Hedgehog signaling controls Th17 polarization and pathogenicity Nature Communications, 13(1):4075.
PMID: 35835905 -
Species: Mouse
Sample Types: Whole Tissue
Applications: IHCT Otsuki et al. (2022), Twist-related protein 1 induces epithelial-mesenchymal transition and renal fibrosis through the upregulation of complement 3 PLoS ONE, 17(8):e0272917.
PMID: 36018840 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationZ Shen et al. (2022), Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn's disease EBioMedicine, 85(0):104285.
PMID: 36182776 -
Species: Mouse
Sample Types: Whole Cells
Applications: ICCA Nawaz et al. (2022), Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration Nature Communications, 13(1):7058.
PMID: 36411280 -
Species: Rat
Sample Types: Cell Lysates
Applications: Western BlotMR Patel et al. (2021), Astrocyte-derived small extracellular vesicles promote synapse formation via fibulin-2-mediated TGF-&beta signaling Cell Reports, 34(10):108829.
PMID: 33691102 -
Species: Bovine
Sample Types: Milk
Applications: ELISA CaptureRJ Playford et al. (2021), Methods to improve efficacy of orally administered bioactive peptides using bovine colostrum as an exemplar PLoS ONE, 16(6):e0253422.
PMID: 34138960 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationQS Liang et al. (2021), Splenectomy improves liver fibrosis via tumor necrosis factor superfamily 14 (LIGHT) through the JNK/TGF-&beta1 signaling pathway Experimental Molecular Medicine, 2021;0(0).
PMID: 33654222 -
Species: Human
Sample Types: Whole Cells
Applications: ICCKV Manian et al. (2021), 3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration Cell Stem Cell, 0(0).
PMID: 33784497 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationG Mestrallet et al. (2021), Human Keratinocytes Inhibit CD4+ T-Cell Proliferation through TGFB1 Secretion and Surface Expression of HLA-G1 and PD-L1 Immune Checkpoints Cells, 10(6).
PMID: 34201301 -
Species: Human
Sample Types: Tissue Homogenates
Applications: Co-IPD Basak et al. (2021), Reciprocal interplay between asporin and decorin: Implications in gastric cancer prognosis PLoS ONE, 16(8):e0255915.
PMID: 34379688 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationY Takagaki et al. (2020), Endothelial autophagy deficiency induces IL6 - dependent endothelial mesenchymal transition and organ fibrosis Autophagy, 0(0):1-10.
PMID: 31965901 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationF Qin et al. (2020), Anti-TGF-&beta attenuates tumor growth via polarization of tumor associated neutrophils towards an anti-tumor phenotype in colorectal cancer J Cancer, 11(9):2580-2592.
PMID: 32201528 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationA van Caam et al. (2020), TGF&beta-mediated expression of TGF&beta-activating integrins in SSc monocytes: disturbed activation of latent TGF&beta? Arthritis Res. Ther., 22(1):42.
PMID: 32143707 -
Species: Human
Sample Types: Plasma
E Rodríguez- et al. (2020), Variations in Circulating Active MMP-9 Levels During Renal Replacement Therapy Biomolecules, 10(4).
PMID: 32225016 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationS Li et al. (2020), Deficiency in Dipeptidyl Peptidase-4 Promotes Chemoresistance through the CXCL12/CXCR4/mTOR/TGF&beta Signaling Pathway in Breast Cancer Cells Int J Mol Sci, 21(3).
PMID: 31991851 -
Species: Mouse
Sample Types: Whole Cells
Applications: Flow CytometryLF Campesato et al. (2020), Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine Nat Commun, 11(1):4011.
PMID: 32782249 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationAP Gomes et al. (2020), Age-induced accumulation of methylmalonic acid promotes tumour progression Nature, 0(0).
PMID: 32814897 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationH Ungefroren et al. (2020), RAC1B Regulation of TGFB1 Reveals an Unexpected Role of Autocrine TGF&beta1 in the Suppression of Cell Motility Cancers, 12(12).
PMID: 33260366 -
Species: Mouse
Sample Types: Whole Cells
Applications: Flow CytometryLF Campesato et al. (2020), Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine Nat Commun, 11(1):4011.
PMID: 32782249 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationAP Gomes et al. (2020), Age-induced accumulation of methylmalonic acid promotes tumour progression Nature, 0(0).
PMID: 32814897 -
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: BioassayW Li et al. (2020), T cells expressing the lupus susceptibility allele Pbx1d enhance autoimmunity and atherosclerosis in dyslipidemic mice JCI Insight, 5(11).
PMID: 32493841 -
Species: Human
Sample Types: Serum
Applications: ELISA Development (Capture)H Yu et al. (2019), TGF??1 upregulates the expression of lncRNA?ATB to promote atherosclerosis Mol Med Rep, 19(5):4222-4228.
PMID: 30942415 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMR Shokri et al. (2019), Human menstrual blood-derived stromal/stem cells modulate functional features of natural killer cells Sci Rep, 9(1):10007.
PMID: 31292483 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotC Hiepen et al. (2019), BMPR2 acts as a�gatekeeper to protect endothelial cells from increased TGF&beta�responses and altered cell mechanics PLoS Biol., 17(12):e3000557.
PMID: 31826007 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationS Tiwary et al. (2018), Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a Sci Rep, 8(1):8267.
PMID: 29844613 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayN Caronni et al. (2018), Downregulation of membrane trafficking proteins and lactate conditioning determine loss of dendritic cell function in lung cancer Cancer Res., 0(0).
PMID: 29363545 -
Species: Human
Sample Types: Whole Cells
Applications: Agonist ActivityL Huang et al. (2018), CD8+ T cells with high TGF??1 expression cause lymph node fibrosis following HIV infection Mol Med Rep, 0(0).
PMID: 29749506 -
Species: Rabbit
Sample Types: Whole Cells
Applications: ICCM Yuan et al. (2018), Proteomic Analysis of Nucleus Pulposus Cell-derived Extracellular Matrix Niche and Its Effect on Phenotypic Alteration of Dermal Fibroblasts Sci Rep, 8(1):1512.
PMID: 29367647 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationCKS Wong et al. (2018), Connective tissue growth factor expression after angiotensin II exposure is dependent on transforming growth factor-? signaling via the canonical Smad-dependent pathway in hypertensive induced myocardial fibrosis J Renin Angiotensin Aldosterone Syst, 19(1):1470320318759.
PMID: 29575960 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotB Liu et al. (2018), Protective effect of KLF15 on vascular endothelial dysfunction induced by TNF?? Mol Med Rep, 18(2):1987-1994.
PMID: 29956764 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationX Wang et al. (2018), TGF-?1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells Stem Cell Reports, 0(0).
PMID: 29937145 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationM Idelson et al. (2018), Immunological Properties of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells Stem Cell Reports, 0(0).
PMID: 30122442 -
Species: Rat
Sample Types: Whole Cells
Applications: NeutralizationB Wang et al. (2018), BMSCs pre-treatment ameliorates inflammation-related tissue destruction in LPS-induced rat DIC model Cell Death Dis, 9(10):1024.
PMID: 30282969 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationT Shindo et al. (2018), TGF-?1 promotes expression of fibrosis-related genes through the induction of histone variant H3.3 and histone chaperone HIRA Sci Rep, 8(1):14060.
PMID: 30232404 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationSS Said et al. (2018), Bacterially activated B-cells drive T cell differentiation towards Tr1 through PD-1/PD-L1 expression Mol. Immunol., 96(0):48-60.
PMID: 29494848 -
Species: Human
Sample Types: Cell Lysate
Applications: Western BlotBing Liu et al. (2018), Protective effect of KLF15 on vascular endothelial dysfunction induced by TNF??. Molecular Medicine Reports, 0(0):1791-3004.
PMID: 29956764 -
Species: Mouse
Sample Types: Whole Cells
Applications: ActivationJR Cortes et al. (2018), RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis Cancer Cell, 33(2):259-273.e7.
PMID: 29398449 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotHR Gatla et al. (2017), Histone Deacetylase (HDAC) Inhibition Induces I?B Kinase (IKK)-dependent Interleukin-8/CXCL8 Expression in Ovarian Cancer Cells J. Biol. Chem., 292(12):5043-5054.
PMID: 28167529 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationM Pasztoi et al. (2017), Mesenteric lymph node stromal cell-derived extracellular vesicles contribute to peripheral de novo induction of Foxp3(+) regulatory T cells Eur. J. Immunol., 0(0).
PMID: 28833065 -
Species: Human
Sample Types: Whole Cells
Applications: Functional AssayL Ritsma et al. (2017), Integrin ?1 activation induces an anti-melanoma host response PLoS ONE, 12(4):e0175300.
PMID: 28448494 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationN Köstlin et al. (2017), Granulocytic myeloid derived suppressor cells from human cord blood modulate T-helper-cell response towards an anti-inflammatory phenotype Immunology, 0(0).
PMID: 28464218 -
Species: Mouse
Sample Types: Whole Tissue
Applications: BioassayQ Bian et al. (2017), Mechanosignaling activation of TGF? maintains intervertebral disc homeostasis Bone Res, 5(0):17008.
PMID: 28392965 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationK Brekke et al. (2017), The therapeutic HIV Env C5/gp41 vaccine candidate Vacc-C5 induces specific T cell regulation in a phase I/II clinical study BMC Infect. Dis, 17(1):228.
PMID: 28340570 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationRM Petri et al. (2017), Activated Tissue-Resident Mesenchymal Stromal Cells Regulate Natural Killer Cell Immune and Tissue-Regenerative Function Stem Cell Reports, 0(0).
PMID: 28781075 -
Species: Mouse
Sample Types: Whole Tissue
Applications: NeutralizationS Khakipoor et al. (2017), TGF-? signaling directly regulates transcription and functional expression of the electrogenic sodium bicarbonate cotransporter 1, NBCe1 (SLC4A4), via Smad4 in mouse astrocytes Glia, 0(0).
PMID: 28568893 -
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western BlotD Gonzalez et al. (2017), ALS skeletal muscle shows enhanced TGF-? signaling, fibrosis and induction of fibro/adipogenic progenitor markers PLoS ONE, 12(5):e0177649.
PMID: 28520806 -
Species: Rat
Sample Types: Whole Cells
Applications: NeutralizationCJ Bohlen et al. (2017), Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures Neuron, 94(4):759-773.e8.
PMID: 28521131 -
Species: Opossum
Sample Types: In Vivo
Applications: In VivoDJ Urban et al. (2017), A new developmental mechanism for the separation of the mammalian middle ear ossicles from the jaw Proc. Biol. Sci, 284(1848).
PMID: 28179517 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationFatemeh Mirzamoham (2016), Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-? signalling Nat Commun, 7(0):12047.
PMID: 27329220 -
Species: Human
Sample Types: Whole Cells
Applications: Neutralization(2016), Tumor-Activated Mesenchymal Stromal Cells Promote Osteosarcoma Stemness and Migratory Potential via IL-6 Secretion PLoS ONE, 11(11):e0166500.
PMID: 27851822 -
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay(2016), Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs Nature, 0(0).
PMID: 27828940 -
Species: Human
Sample Types: Whole Cells
Applications: Neutralization(2016), TGF-?1 Is Present at High Levels in Wound Fluid from Breast Cancer Patients Immediately Post-Surgery, and Is Not Increased by Intraoperative Radiation Therapy (IORT) PLoS ONE, 11(9):e0162221.
PMID: 27589056 -
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo(2016), Apoptotic cell infusion treats ongoing collagen-induced arthritis, even in the presence of methotrexate, and is synergic with anti-TNF therapy Arthritis Res Ther, 18(1):184.
PMID: 27516061 -
H Nagashima et al. (2016), TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development J Immunol, 0(0).
PMID: 27076680 -
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC(2016), Sterile Inflammation Enhances ECM Degradation in Integrin ?1 KO Embryonic Skin Cell Rep, 16(12):3334-47.
PMID: 27653694 -
Species: Mink
Sample Types: Whole Cells
Applications: NeutralizationI Minn et al. (2016), [64Cu]XYIMSR-06: A dual-motif CAIX ligand for PET imaging of clear cell renal cell carcinoma Oncotarget, 7(35):56471-56479.
PMID: 27437764 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationJeremy S Duffield (2016), Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury J. Clin. Invest., 0(0).
PMID: 27869651 -
Species: Rat
Sample Types: Tissue Homogenates
Applications: Western BlotFornetti J et al. (2016), Mammary epithelial cell phagocytosis downstream of TGF-beta3 is characterized by adherens junction reorganization. Cell Death Differ, 23(2):185-96.
PMID: 26113040 -
Species: Human
Sample Types: Whole Cells
Applications: Neutralization(2016), Kluyveromyces marxianus and Saccharomyces boulardii Induce Distinct Levels of Dendritic Cell Cytokine Secretion and Significantly Different T Cell Responses In Vitro PLoS ONE, 11(11):e0167410.
PMID: 27898740 -
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay(2016), K+/Cl- cotransporter KCC2 membrane trafficking and functionality is regulated by transforming growth factor beta 2 J Cell Sci, 0(0).
PMID: 27505893 -
Species: Human
Sample Types: Cell Culture Supernates
Applications: NeutralizationS S Prime (2016), Cancer associated fibroblasts regulate keratinocyte cell-cell adhesion via TGF-�-dependent pathways in genotype-specific oral cancer Carcinogenesis, 0(0).
PMID: 27803052 -
Species: Human
Sample Types: Whole Cells
Applications: Neutralization(2016), Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes Stem Cell Reports, 0(0).
PMID: 27569062 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationX Chen et al. (2016), TGF-? Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions PLoS ONE, 11(4):e0153811.
PMID: 27104863 -
Species: Human
Sample Types: Whole Cells
Applications: BlockingSchmetterer K et al. (2015), STAT3 governs hyporesponsiveness and granzyme B-dependent suppressive capacity in human CD4+ T cells. FASEB J, 29(3):759-71.
PMID: 25398767 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationDutta A et al. (2015), IL-10 inhibits neuraminidase-activated TGF-beta and facilitates Th1 phenotype during early phase of infection. Nat Commun, 6(0):6374.
PMID: 25728041 -
Species: Bovine
Sample Types: Milk
Applications: NeutralizationKippenberger S et al. (2015), STAT6-Dependent Collagen Synthesis in Human Fibroblasts Is Induced by Bovine Milk. PLoS ONE, 10(7):e0131783.
PMID: 26134630 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationCarrillo-Galvez A et al. (2015), Mesenchymal stromal cells express GARP/LRRC32 on their surface: effects on their biology and immunomodulatory capacity. Stem Cells, 33(1):183-95.
PMID: 25182959 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationPieters B et al. (2015), Commercial cow milk contains physically stable extracellular vesicles expressing immunoregulatory TGF-beta. PLoS ONE, 10(3):e0121123.
PMID: 25822997 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationMizuuchi Y et al. (2015), Anterior gradient 2 downregulation in a subset of pancreatic ductal adenocarcinoma is a prognostic factor indicative of epithelial-mesenchymal transition. Lab Invest, 95(2):193-206.
PMID: 25418581 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationLi Y et al. (2015), Iron-induced Local Complement Component 3 (C3) Up-regulation via Non-canonical Transforming Growth Factor (TGF)-beta Signaling in the Retinal Pigment Epithelium. J Biol Chem, 290(19):11918-34.
PMID: 25802332 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationRossetti M et al. (2015), Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region. J Immunol, 194(1):113-24.
PMID: 25452562 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationChang T et al. (2015), Bortezomib inhibits expression of TGF-beta1, IL-10, and CXCR4, resulting in decreased survival and migration of cutaneous T cell lymphoma cells. J Immunol, 194(6):2942-53.
PMID: 25681335 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationDayer C et al. (2015), Recruitment of Matrix Metalloproteinase-9 (MMP-9) to the Fibroblast Cell Surface by Lysyl Hydroxylase 3 (LH3) Triggers Transforming Growth Factor-beta (TGF-beta) Activation and Fibroblast Differentiation. J Biol Chem, 290(22):13763-78.
PMID: 25825495 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationUngefroren H et al. (2015), Pluripotency gene expression and growth control in cultures of peripheral blood monocytes during their conversion into programmable cells of monocytic origin (PCMO): evidence for a regulatory role of autocrine activin and TGF-beta. PLoS ONE, 10(2):e0118097.
PMID: 25707005 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationGallo E et al. (2014), Angiotensin II-dependent TGF-beta signaling contributes to Loeys-Dietz syndrome vascular pathogenesis. J Clin Invest, 124(1):448-60.
PMID: 24355923 -
Species: Human
Sample Types: Cell Culture Supernates
Applications: NeutralizationHassona Y et al. (2014), Senescent cancer-associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion. Br J Cancer, 111(6):1230-7.
PMID: 25117810 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationJolly L et al. (2014), Influenza promotes collagen deposition via alphavbeta6 integrin-mediated transforming growth factor beta activation. J Biol Chem, 289(51):35246-63.
PMID: 25339175 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationAlcaraz L et al. (2014), Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-beta. J Cell Biol, 205(3):409-28.
PMID: 24821840 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationMusso A et al. (2014), Aminobisphosphonates prevent the inhibitory effects exerted by lymph node stromal cells on anti-tumor Vdelta 2 T lymphocytes in non-Hodgkin lymphomas. Haematologica, 99(1):131-9.
PMID: 24162786 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationGao P et al. (2014), Functional effects of TGF-beta1 on mesenchymal stem cell mobilization in cockroach allergen-induced asthma. J Immunol, 192(10):4560-70.
PMID: 24711618 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationLin Z et al. (2014), CD4(+) NKG2D(+) T cells induce NKG2D down-regulation in natural killer cells in CD86-RAE-1epsilon transgenic mice. Immunology, 141(3):401-15.
PMID: 24708417 -
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western BlotWu Z et al. (2014), Biglycan and decorin differentially regulate signaling in the fetal membranes. Matrix Biol, 35(0):266-75.
PMID: 24373743 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationNagashima et al. (2014), The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6. Nat Immunol, 15(5):449-56.
PMID: 24681564 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationCraft C et al. (2014), The extracellular matrix protein MAGP1 supports thermogenesis and protects against obesity and diabetes through regulation of TGF-beta. Diabetes, 63(6):1920-32.
PMID: 24458361 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationFaustino L et al. (2014), Tumor necrosis factor-related apoptosis-inducing ligand mediates the resolution of allergic airway inflammation induced by chronic allergen inhalation. Mucosal Immunol, 7(5):1199-208.
PMID: 24569802 -
Species: Bovine
Sample Types: Whole Cells
Applications: BioassayGuzman E et al. (2014), Bovine gammadelta T cells are a major regulatory T cell subset. J Immunol, 193(1):208-22.
PMID: 24890724 -
Species: Canine
Sample Types: Whole Cells
Applications: NeutralizationWeaver S et al. (2014), Basal localization of MT1-MMP is essential for epithelial cell morphogenesis in 3D collagen matrix. J Cell Sci, 127(0):1203-13.
PMID: 24463815 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationCook J et al. (2014), Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome. J Clin Invest, 124(3):1329-39.
PMID: 24531548 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationKashiwakura Y et al. (2013), CD2-mediated regulation of peripheral CD4(+) CD25(+) regulatory T-cell apoptosis accompanied by down-regulation of Bim. Immunology, 139(1):48-60.
PMID: 23278598 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationGuo Z et al. (2013), A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells. J Immunol, 190(7):3153-62.
PMID: 23427250 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationNakagawa R et al. (2013), Peyer's patch inducer cells play a leading role in the formation of B and T cell zone architecture. J Immunol, 190(7):3309-18.
PMID: 23460741 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationGandhi N et al. (2013), Dendritic cell-derived thrombospondin-1 is critical for the generation of the ocular surface Th17 response to desiccating stress. J Leukoc Biol, 94(6):1293-301.
PMID: 23983225 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationSchreiner J et al. (2013), Staphylococcus aureus phenol-soluble modulin peptides modulate dendritic cell functions and increase in vitro priming of regulatory T cells. J Immunol, 190(7):3417-26.
PMID: 23460735 -
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: ImmunodepletionBialas A et al. (2013), TGF-beta signaling regulates neuronal C1q expression and developmental synaptic refinement. Nat Neurosci, 16(12):1773-82.
PMID: 24162655 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationZhou A et al. (2013), The metalloprotease ADAM12 regulates the effector function of human Th17 cells. PLoS ONE, 8(11):e81146.
PMID: 24363794 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationNorris B et al. (2013), Chronic but not acute virus infection induces sustained expansion of myeloid suppressor cell numbers that inhibit viral-specific T cell immunity. Immunity, 38(2):309-21.
PMID: 23438822 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationYu C et al. (2013), Human CD1c+ dendritic cells drive the differentiation of CD103+ CD8+ mucosal effector T cells via the cytokine TGF-beta. Immunity, 38(4):818-30.
PMID: 23562160 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationZhang N et al. (2012), TGF-beta signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation. Nat. Immunol., 13(7):667-73.
PMID: 22634866 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationZielinski CE et al. (2012), Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta. Nature, 484(7395):514-8.
PMID: 22466287 -
Species: Mouse
Sample Types: Whole Cells
Applications: Flow CytometryMontane J et al. (2011), Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets. J. Clin. Invest., 121(0):3024.
PMID: 21737880 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationChaturvedi V et al. (2011), Cutting edge: Human regulatory T cells require IL-35 to mediate suppression and infectious tolerance. J. Immunol., 186(12):6661-6.
PMID: 21576509 -
Species: Human
Sample Types: Whole Cells
Applications: ICCMa W et al. (2011), Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease. J. Clin. Invest., 121(11):4548-66.
PMID: 22005303 -
Species: Canine
Sample Types: Whole Cells
Applications: NeutralizationGregory PA et al. (2011), An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Mol. Biol. Cell, 22(10):1686-98.
PMID: 21411626 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationSrivastava K et al. (2010), Anti-Asthma Simplified Herbal Medicine Intervention-induced long-lasting tolerance to allergen exposure in an asthma model is interferon-gamma, but not transforming growth factor-beta dependent. Clin. Exp. Allergy, 40(11):1678-88.
PMID: 20573156 -
Species: Mouse
Sample Types: Cell Lysates
Applications: BioassayLinke A et al. (2010), Epithelial overexpression of SOCS-3 in transgenic mice exacerbates wound inflammation in the presence of elevated TGF-beta1. J. Invest. Dermatol., 130(3):866-75.
PMID: 19924141 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationLu H et al. (2010), Treatment failure of a TLR-7 agonist occurs due to self-regulation of acute inflammation and can be overcome by IL-10 blockade. J. Immunol., 184(9):5360-7.
PMID: 20308630 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationTso GH et al. (2010), Phagocytosis of apoptotic cells modulates mesenchymal stem cells osteogenic differentiation to enhance IL-17 and RANKL expression on CD4+ T cells. Stem Cells, 28(5):939-54.
PMID: 20222014 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationKoo JW et al. (2010), Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proc. Natl. Acad. Sci. U.S.A., 107(6):2669-74.
PMID: 20133768 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationHan G et al. (2010), Interleukin-17-producing gammadelta+ T cells protect NOD mice from type 1 diabetes through a mechanism involving transforming growth factor-beta. Immunology, 129(2):197-206.
PMID: 19824917 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationSchraml BU et al. (2009), The AP-1 transcription factor Batf controls T(H)17 differentiation. Nature, 460(7253):405-9.
PMID: 19578362 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationNicola T et al. (2009), Loss of Thy-1 inhibits alveolar development in the newborn mouse lung. Am. J. Physiol. Lung Cell Mol. Physiol., 296(5):L738-50.
PMID: 19270178 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationHan Y et al. (2009), CD69+ CD4+ CD25- T cells, a new subset of regulatory T cells, suppress T cell proliferation through membrane-bound TGF-beta 1. J. Immunol., 182(1):111-20.
PMID: 19109141 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationTran DQ et al. (2009), Analysis of adhesion molecules, target cells, and role of IL-2 in human FOXP3+ regulatory T cell suppressor function. J. Immunol., 182(5):2929-38.
PMID: 19234188 -
Species: Human
Sample Types: Whole Tissue
Applications: IHCPrignano F et al. (2009), Fractional CO2 laser: a novel therapeutic device upon photobiomodulation of tissue remodeling and cytokine pathway of tissue repair. Dermatol Ther, 22(0):S8-15.
PMID: 19891690 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationAliahmadi E et al. (2009), TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23. Eur. J. Immunol., 39(5):1221-30.
PMID: 19350551 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationIlarregui JM et al. (2009), Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10. Nat. Immunol., 10(9):981-91.
PMID: 19668220 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationPerruche S et al. (2008), CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells. Nat. Med., 14(5):528-35.
PMID: 18438416 -
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: NeutralizationHaanstra KG et al. (2008), Characterization of naturally occurring CD4+CD25+ regulatory T cells in rhesus monkeys. Transplantation, 85(8):1185-92.
PMID: 18431240 -
Species: Human
Sample Types: Whole Cells
Applications: Neutralizationvan der Vliet HJ et al. (2008), Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells. J. Immunol., 180(11):7287-93.
PMID: 18490728 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationTerme M et al. (2008), Regulatory T cells control dendritic cell/NK cell cross-talk in lymph nodes at the steady state by inhibiting CD4+ self-reactive T cells. J. Immunol., 180(7):4679-86.
PMID: 18354191 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationPen A et al. (2008), Glioblastoma-secreted factors induce IGFBP7 and angiogenesis by modulating Smad-2-dependent TGF-beta signaling. Oncogene, 27(54):6834-44.
PMID: 18711401 -
Species: Mouse
Sample Types: Whole Tissue
Applications: NeutralizationCarlson ME et al. (2008), Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells. Nature, 454(7203):528-32.
PMID: 18552838 -
Species: Rat
Sample Types: In Vivo
Applications: NeutralizationAkool el-S et al. (2008), Molecular mechanisms of TGFbeta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506. J. Immunol., 181(4):2831-45.
PMID: 18684975 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryTabata T et al. (2008), Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production. Am. J. Pathol., 172(4):1127-40.
PMID: 18349127 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationHe R et al. (2007), Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge. Proc. Natl. Acad. Sci. U.S.A., 104(40):15817-22.
PMID: 17893340 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationAlatrakchi N et al. (2007), Hepatitis C virus (HCV)-specific CD8+ cells produce transforming growth factor beta that can suppress HCV-specific T-cell responses. J. Virol., 81(11):5882-92.
PMID: 17376924 -
Species: Human
Sample Types: Cell Culture Supernates
Applications: Luminex DevelopmentBiancotto A et al. (2007), Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood, 109(10):4272-9.
PMID: 17289812 -
Species: Porcine
Sample Types: Cell Culture Supernates
Applications: ELISA DevelopmentSaurer L et al. (2007), In vitro induction of mucosa-type dendritic cells by all-trans retinoic acid. J. Immunol., 179(6):3504-14.
PMID: 17785784 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationLamar JM et al. (2007), Integrin alpha3beta1 potentiates TGFbeta-mediated induction of MMP-9 in immortalized keratinocytes. J. Invest. Dermatol., 128(3):575-86.
PMID: 17762853 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationRosendahl AH et al. (2006), IGF-I and IGFBP-3 augment transforming growth factor-beta actions in human renal carcinoma cells. Kidney Int., 70(9):1584-90.
PMID: 16969385 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationKoelle DM et al. (2006), Innate immune responses to herpes simplex virus type 2 influence skin homing molecule expression by memory CD4+ lymphocytes. J. Virol., 80(6):2863-72.
PMID: 16501095 -
Species: Mouse
Sample Types: Cell Lysates
Applications: Western BlotFunaba M et al. (2006), Requirement of Smad3 for mast cell growth. Cell. Immunol., 240(1):47-52.
PMID: 16839529 -
Species: Bovine
Sample Types: Whole Cells
Applications: NeutralizationFazzini M et al. (2006), Transforming growth factor beta1 regulates follistatin mRNA expression during in vitro bovine granulosa cell differentiation. J. Cell. Physiol., 207(1):40-8.
PMID: 16245315 -
Species: Rat
Sample Types: Whole Tissue
Applications: NeutralizationMaeshima A et al. (2006), Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev. Biol., 295(2):473-85.
PMID: 16643884 -
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-FrDasgupta S et al. (2006), Tumor metastasis in an orthotopic murine model of head and neck cancer: possible role of TGF-beta 1 secreted by the tumor cells. J. Cell. Biochem., 97(5):1036-51.
PMID: 16294321 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationKarrar A et al. (2006), Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction. Gut, 56(2):243-52.
PMID: 16840505 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationNeurohr C et al. (2006), Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure. Am. J. Respir. Cell Mol. Biol., 35(2):252-9.
PMID: 16574941 -
Species: Bovine
Sample Types: Whole Cells
Applications: NeutralizationSeo KS et al. (2006), Long-term staphylococcal enterotoxin C1 exposure induces soluble factor-mediated immunosuppression by bovine CD4+ and CD8+ T cells. Infect. Immun., 75(1):260-9.
PMID: 17030573 -
Species: Rat
Sample Types: In Vivo
Applications: NeutralizationClose JL et al. (2005), Retinal neurons regulate proliferation of postnatal progenitors and Muller glia in the rat retina via TGF beta signaling. Development, 132(13):3015-26.
PMID: 15944186 -
Species: Mouse
Applications: NeutralizationHuang X et al. (2005), Protection against autoimmunity in nonlymphopenic hosts by CD4+ CD25+ regulatory T cells is antigen-specific and requires IL-10 and TGF-beta. J. Immunol., 175(7):4283-91.
PMID: 16177068 -
Species: Human
Sample Types: Cell Culture Supernates
Applications: NeutralizationGodfrey WR et al. (2005), Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood, 105(2):750-8.
PMID: 15374887 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryGodfrey WR et al. (2004), In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures. Blood, 104(2):453-61.
PMID: 15031211 -
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Tissue Homogenates
Applications: Western BlotTorrealba JR et al. (2004), Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates. J. Immunol., 172(9):5753-64.
PMID: 15100322 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationKitani A et al. (2004), TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice. J. Immunol., 172(2):834-42.
PMID: 14707053 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometrySen Y et al. (2004), Aberration of CCR7 CD8 memory T cells from patients with systemic lupus erythematosus: an inducer of T helper type 2 bias of CD4 T cells. Immunology, 112(2):274-89.
PMID: 15147571 -
Species: Mouse
Sample Types: Cell Lysates
Applications: Western BlotPaliwal S et al. (2004), P311 binds to the latency associated protein and downregulates the expression of TGF-beta1 and TGF-beta2. Biochem. Biophys. Res. Commun., 315(4):1104-9.
PMID: 14985127 -
Species: Hamster
Sample Types: Whole Cells
Applications: NeutralizationMookerjee A et al. (2003), Immunosuppression in hamsters with progressive visceral leishmaniasis is associated with an impairment of protein kinase C activity in their lymphocytes that can be partially reversed by okadaic acid or anti-transforming growth factor beta antibody. Infect. Immun., 71(5):2439-46.
PMID: 12704114 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationKoenen HJ et al. (2003), IL-15 and cognate antigen successfully expand de novo-induced human antigen-specific regulatory CD4+ T cells that require antigen-specific activation for suppression. J. Immunol., 171(12):6431-41.
PMID: 14662842 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationChen et al. (2003), Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med, 198(12):1875-86.
PMID: 14676299 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationKobayashi T et al. (2003), Marked airway eosinophilia prevents development of airway hyper-responsiveness during an allergic response in IL-5 transgenic mice. J. Immunol., 170(11):5756-63.
PMID: 12759459 -
Species: Chicken
Sample Types: Whole Cells
Applications: NeutralizationFeugate JE et al. (2002), The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure. e0216795, 156(1):161-72.
PMID: 11781340 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationSchmidt A et al. (0), Human macrophages induce CD4(+)Foxp3(+) regulatory T cells via binding and re-release of TGF-beta. Immunol Cell Bio94(8):747-62.
PMID: 27075967 -
Species: Mouse
Sample Types: Whole Cells
Applications: Flow CytometryZhang P et al. (0), PARP-1 regulates expression of TGF-beta receptors in T cells. Bloo122(13):2224-32.
PMID: 23940283 -
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western BlotChakrabarti L et al. (0), A mechanism linking Id2-TGFbeta crosstalk to reversible adaptive plasticity in neuroblastoma. PLoS ON8(12):e83521.
PMID: 24376712 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayCarthy J et al. (0), Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF-beta Signaling. J Cell Bioche117(4):938-45.
PMID: 26369756
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Customer Reviews for TGF-beta 1, 2, 3 Antibody (12)
Customer Images
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Application: Weak antibody requires high concentrationSample Tested: HepG2 human hepatocellular carcinoma cell lineSpecies: HumanVerified Customer | Posted 12/06/2022
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Application: WBSample Tested: Dermal fibroblastsSpecies: MouseVerified Customer | Posted 08/05/2021
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Application: WBSample Tested: Adult pancreasSpecies: MouseVerified Customer | Posted 10/27/2020
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Application: WBSample Tested: Pancreas tissueSpecies: MouseVerified Customer | Posted 10/13/2020
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Application: B/NSample Tested: 3T3-L1 mouse embryonic fibroblast adipose-like cell lineSpecies: MouseVerified Customer | Posted 07/09/2019
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Application: WBSample Tested: Muscle tissueSpecies: MouseVerified Customer | Posted 04/30/2019
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Application: ELISASample Tested: Recombinant proteinSpecies: HumanVerified Customer | Posted 03/28/2019
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Application: WBSample Tested: Skin cancer tissueSpecies: MouseVerified Customer | Posted 01/28/2019
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Application: IHCSample Tested: Tonsil tissueSpecies: HumanVerified Customer | Posted 05/22/2018
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Application: IHCSample Tested: Skin cancer tissueSpecies: MouseVerified Customer | Posted 04/24/2018
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Application: ICC/IFSample Tested: A549 human lung carcinoma cell lineSpecies: HumanVerified Customer | Posted 07/21/2017
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Application: B/NSample Tested: Peritoneal macrophagesSpecies: MouseVerified Customer | Posted 05/16/2017
There are no reviews that match your criteria.
FAQs for TGF-beta 1, 2, 3 Antibody
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Can the TGF-beta 1, 2, 3 Antibody, Cat# MAB1835, neutralize the activity of all three TGF-beta proteins?
Yes, this antibody can neutralize the activity of TGF-beta 1, 2, and 3 proteins.