SARS-CoV-2 Spike S1 Protein Antibody (1035224) [CoraFluor™ 1]
Novus Biologicals, part of Bio-Techne | Catalog # FAB105405CL1
![SARS-CoV-2 Spike S1 Protein Antibody (1035224) [CoraFluor™ 1]](https://resources.bio-techne.com/images/products/fab105405cl1_mu-sars-cov-2-spike-s1-protein-mab-1035224-corafluor-1-269202517314613.png "Product Feature: CoraFluor Probes for TR-FRET")
Conjugate
Catalog #
Key Product Details
Species Reactivity
SARS-CoV-2
Applications
Blockade of Receptor-ligand Interaction
Label
CoraFluor 1
Antibody Source
Monoclonal Mouse IgG1 Clone # 1035224
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
HEK293-derived SARS-CoV-2 Spike S1 Subunit
Accession # YP_009724390.1
Accession # YP_009724390.1
Specificity
Detects SARS-CoV-2 Spike S1 RBD and SARS-CoV-2 B.1.1.529 S RBD (Omicron Variant) in direct ELISAs
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1
Description
CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(TM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
CoraFluor(TM) 1, amine reactive
CoraFluor(TM) 1, thiol reactive
For more information, please see our CoraFluor(TM) TR-FRET technology flyer.
CoraFluor(TM) 1, amine reactive
CoraFluor(TM) 1, thiol reactive
For more information, please see our CoraFluor(TM) TR-FRET technology flyer.
Scientific Data Images for SARS-CoV-2 Spike S1 Protein Antibody (1035224) [CoraFluor™ 1]
Product Feature: CoraFluor Probes for TR-FRET
CoraFluor™ 1, amine reactive (Catalog:7920) and CoraFluor™ 2, amine reactive (Catalog # 7950) are terbium-based probes that have been developed for use as TR-FRET donors. They emit wavelengths compatible with commonly used fluorescent acceptor dyes such as BODIPY® (or BDY) and Janelia Fluor® dyes, FITC (Catalog # 5440), TMR and Cyanine 5 (Catalog # 5436). CoraFluor™ fluorescence is brighter and more stable in biological media than existing TR-FRET donors, leading to enhanced sensitivity and improved data generation. CoraFluor™ 1 exhibits excitation upon exposure to a 337 nm UV laser.Applications for SARS-CoV-2 Spike S1 Protein Antibody (1035224) [CoraFluor™ 1]
Application
Recommended Usage
Blockade of Receptor-ligand Interaction
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Formulation
PBS
Preservative
No Preservative
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark. Do not freeze.
Background: Spike S1 Subunit
Spike S1 subunit refers to the N-terminal part of the coronavirus Spike protein. The S1 subunit contains an N-terminal domain in addition to the much-studied receptor binding domain (RBD). Spatially, the S1 subunit represents the most membrane-distal portion of the spike protein. For SARS-CoV-2, this subunit, specifically the RBD domain, is responsible for binding to ACE-2 on the surface of human cells and initiating viral entry. Because this interaction is so important for viral entry into host cells, the RBD domain has been the focus of therapeutic and vaccine development for COVID-19. The N-terminal domain of the S1 subunit may also be involved in receptor binding independent of ACE-2. Current research is underway to better understand this domain as it may unlock new therapeutic strategies to fight SARS-CoV-2.
Long Name
Spike Protein, S1 Subunit
Alternate Names
SARS-CoV-2
Additional Spike S1 Subunit Products
Product Documents for SARS-CoV-2 Spike S1 Protein Antibody (1035224) [CoraFluor™ 1]
Product Specific Notices for SARS-CoV-2 Spike S1 Protein Antibody (1035224) [CoraFluor™ 1]
CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Loading...
Loading...
Loading...