Mouse IL-17C Alexa Fluor® 405-conjugated Antibody

Name: Mouse IL-17C Alexa Fluor® 405-conjugated Antibody
Brand: R&D Systems
SKU: IC23061V

R&D Systems, Inc. a Bio-Techne Brand

Catalog # IC23061V

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Species Reactivity:	Mouse
Immunogen:	E. coli-derived recombinant mouse IL‑17C His15-Gln194 Accession # NP_665833
Applications:	Flow Cytometry
Label:	Alexa Fluor 405 (Excitation=405 nm, Emission=421 nm)
Specificity:	Detects mouse IL-17C in direct ELISAs.

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Applications for Mouse IL-17C Alexa Fluor® 405-conjugated Antibody

	Recommended Concentration	Sample
Intracellular Staining by Flow Cytometry	0.25-1 µg/10⁶ cells	Tramp‑C1 mouse prostate cancer cell line fixed with paraformaldehyde and permeabilized with saponin

Please Note: Optimal dilutions should be determined by each laboratory for each application.

Formulation, Preparation and Storage

Formulation	Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store the unopened product at 2 - 8 °C. Do not use past expiration date.

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Background: IL-17C

The Interleukin 17 (IL-17) family proteins, comprising six members (IL-17, IL-17B through IL-17F), are secreted, structurally related proteins that share a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus (1, 2). With the exception of IL-17B, which exists as a non‑covalently linked dimer, all IL-17 family members are disulfide-linked dimers (3). IL-17 family proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions (1, 2). Two receptors (IL-17 R, and IL-17B R), which are activated by IL-17 family members have been identified. In addition, at least three additional orphan type I transmembrane receptors with homology to IL-17 R, including IL-17 RL (IL-17 RC), IL-17 RD, and
IL‑17 RE, have also been reported (1‑4). The functions of IL-17 RC, D, and E are not known.

Mouse IL-17C cDNA encodes a 194 amino acid (aa) residues protein with a putative 14 aa signal peptide (5). Although there are no potential N-linked glycosylation sites, it is reportedly glycosylated (6). IL-17C shares from 15%‑30% aa sequence identity with other IL-17 family members. Mouse and human IL-17C share 83% aa sequence identity. IL-17C has a very restricted expression pattern and was detected as a rare expressed sequence tag (EST) in an adult prostate and fetal kidney libraries (2). IL-17C has been shown to stimulate the release of TNF-alpha and IL-1 beta from the monocytic cell line THP-1, a property it shares with IL-17B (6, 7). Human IL‑17C is active on mouse cells (5). The receptor of IL-17C has not yet been identified. The IL-17C preparations from R&D Systems have been found to bind immobilized recombinant mouse IL-17B R/Fc in a functional ELISA.

Item	Value
References	Aggarwal, S. and A.L. Gurney (2002) J. Leukoc. Biol. 71:1. Moseley, T.A. et al. (2003) Cytokine & Growth Factor Rev. 14:155. Hymowitz, S.G. et al. (2001) EMBO J. 20:5332. Haudenschild, D. et al. (2002) J. Biol. Chem. 277:4309. Hurst, S.D. et al. (2002) J. Immunology 169:443. Li, H. et al. (2000) Proc. Natl. Acad. Sci. USA 97:773. Shi, Y. et al. (2000) J. Biol. Chem. 275:19167.
Long Name	Interleukin 17C
Entrez Gene IDs	27189 (Human); 234836 (Mouse)
Alternate Names	CX2, Cytokine CX2, IL-17C, IL-17CMGC126884, IL17C, MGC138401, interleukin 17C, interleukin-17C

Product Specific Notices for Mouse IL-17C Alexa Fluor® 405-conjugated Antibody

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

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Mouse IL-17C Alexa Fluor® 405-conjugated Antibody

R&D Systems, Inc. a Bio-Techne Brand

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Formulation, Preparation and Storage

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Background: IL-17C

Product Specific Notices for Mouse IL-17C Alexa Fluor® 405-conjugated Antibody

Citations for Mouse IL-17C Alexa Fluor® 405-conjugated Antibody

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